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Condition: Dermatomyositis
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Total 3 results found since Jan 2013.
MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway
Conclusions: MiR-146a regulates inflammatory macrophage infiltration in PM/DM by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.Cell Physiol Biochem 2016;40:486-498
Source: Cellular Physiology and Biochemistry - November 24, 2016 Category: Cytology Source Type: research
Expression of the Dermatomyositis Autoantigen TIF1γ in Regenerating Muscle
Conclusion. The DM autoantigen TIF1γ is markedly upregulated during muscle regeneration in human and mouse muscle cells. Premature silencing of this protein in cultured myoblasts accelerates MyHC expression and myoblast fusion. However, TIF1γ may function independently of, or downstream from myogenin. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 3, 2014 Category: Rheumatology Authors: Payam Mohassel, Paul Rosen, Livia Casciola‐Rosen, Katherine Pak, Andrew L. Mammen Tags: Full Length Source Type: research
The down-regulation of miR-223 contributes to the formation of Gottron's eruption via the induction of PKCɛ in dermatomyositis
Gottron's eruption, one of the skin manifestations of dermatomyositis (DM) characterized by acanthosis and hyperkeratosis as well as basal layer liquefaction degeneration, is rather specific to DM and has a great diagnostic value. However, its pathogenesis remains unclear. The aim of this study was to investigate expression pattern of microRNAs (miRNAs) in Gottron's eruption of DM patients and to evaluate the possibility that miRNAs play some parts in its pathogenesis. miRNAs were extracted from tissues and sera of DM, clinically amyopathic DM (CADM) and healthy controls.To determine pathogenic miRNAs, we performed miRNA p...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Kuniko Inoue, Masatoshi Jinnin, Keitaro Yamane, Asako Ichihara, Katsunari Makino, Noritoshi Honda, Wakana Nakayama, Satoshi Fukushima, Yuji Inoue, Hironobu Ihn Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research
