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Specialty: Internal Medicine
Condition: Atrial Fibrillation
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Total 509 results found since Jan 2013.
Edoxaban was noninferior to warfarin for preventing stroke or systemic embolism in atrial fibrillation.
PMID: 24638185 [PubMed - in process]
Source: Annals of Internal Medicine - March 18, 2014 Category: Internal Medicine Authors: Johnson SA, Rondina MT Tags: Ann Intern Med Source Type: research
Novel anticoagulants in patients with mechanical heart valves
Commentary on: Eikelboom JW, Connolly SJ, Brueckmann M, et al.. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med 2013;369:1206. Context Novel anticoagulants (including the direct thrombin inhibitor dabigatran etixilate) and oral factor Xa inhibitors have similar or superior efficacy and safety to warfarin for reducing thromboembolic stroke in patients with atrial fibrillation, and for prevention of deep venous thrombosis. Eikelboom and colleagues set out to examine whether these novel anticoagulants could be used as an alternative to warfarin in patients with mechanical heart valves. Method...
Source: Evidence-Based Medicine - May 19, 2014 Category: Internal Medicine Authors: Stewart, R. A. H. Tags: Drugs: cardiovascular system, Stroke, Venous thromboembolism Therapeutics Source Type: research
Risk of thromboembolism and fatal stroke in patients with psoriasis and non‐valvular atrial fibrillation: a Danish nationwide cohort study
ConclusionsIn patients with non‐valvular atrial fibrillation not treated with oral anticoagulation severe psoriasis was associated with increased risk of thromboembolism. In these patients CHA2DS2VASc underestimated the risk of thromboembolism.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - May 1, 2014 Category: Internal Medicine Authors: Ole Ahlehoff, Gunnar Gislason, Morten Lamberts, Fredrik Folke, Jesper Lindhardsen, Carsten Toftager Larsen, Christian Torp‐Pedersen, Peter Riis Hansen Tags: Original Article Source Type: research
Controversies regarding the new oral anticoagulants for stroke prevention in patients with atrial fibrillation
This article raises 10 controversial issues regarding the use of NOACs for stroke prevention in patients with atrial fibrillation, and offers a review of the latest available evidence. We provide a brief overview of the mechanism and dosing of these drugs, as well as a summary of the key clinical trials that have brought them into the spotlight. Comparative considerations relative to warfarin such as NOAC safety, efficacy, bleeding risk, reversibility, drug-transitioning and use in patients well controlled on warfarin are addressed. Use in select populations such as the elderly, those with coronary disease, renal impairmen...
Source: Vascular Medicine recent issues - May 30, 2014 Category: Internal Medicine Authors: Mohanty, B. D., Looser, P. M., Gokanapudy, L. R., Handa, R., Mohanty, S., Choi, S. S., Goldman, M. E., Fuster, V., Halperin, J. L. Tags: Review Articles Source Type: research
Risk of thromboembolism and fatal stroke in patients with psoriasis and nonvalvular atrial fibrillation: a Danish nationwide cohort study
ConclusionsIn patients with nonvalvular atrial fibrillation not treated with oral anticoagulation, severe psoriasis was associated with increased risk of thromboembolism. In these patients, CHA2DS2VASc underestimated the risk of thromboembolism.
Source: Journal of Internal Medicine - June 13, 2014 Category: Internal Medicine Authors: O. Ahlehoff, G. Gislason, M. Lamberts, F. Folke, J. Lindhardsen, C. T. Larsen, C. Torp‐Pedersen, P. R. Hansen Tags: Original Article Source Type: research
Cryptogenic stroke, atrial fibrillation and primary prevention.
PMID: 25468252 [PubMed - in process]
Source: European Journal of Internal Medicine - December 1, 2014 Category: Internal Medicine Authors: Schattner A, Hadad A Tags: Eur J Intern Med Source Type: research
Interruption of all anticoagulation is non-inferior to the use of short-term parenteral bridging in patients with atrial fibrillation undergoing invasive procedures
Commentary on: Douketis JD, Spyropoulos AC, Kaatz S, et al., BRIDGE Investigators. Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med 2015;373:823–33 . Context Oral anticoagulation (OAC) has been demonstrated to reduce stroke in patients with atrial fibrillation (AF), however, its use conveys an increased risk of bleeding.1 Therefore, patients receiving OAC who undergo invasive procedures often ‘interrupt’ OAC. Use of short-term ‘bridging’ anticoagulants during such interruptions has been the source of significant debate.2 Although guidelines support a ri...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Steinberg, B. A. Tags: Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Valvar diseases, Arrhythmias Therapeutics/Prevention Source Type: research
Intermediate and long-term cognitive effects in older adults secondary to cardiovascular procedures is uncommon but current evidence is insufficient
Commentary on: Fink HA, Hemmy LS, MacDonald R, et al. Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review. Ann Intern Med 2015;163:107–17 . Context Cardiovascular procedures are common in the older population.1 There is suspicion that these procedures may have a negative outcome on cognition.2 However, further research has indicated that there may have been pre-existing cognitive deficits as cognitive impairment is common in the older population.3 This systematic review examines the evidence of the relationship of coronary and carotid revascularisation, ...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Charles, L. Tags: Health policy, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Dementia, Stroke, Interventional cardiology, Memory disorders (psychiatry), Radiology, Clinical diagnostic tests, Health service research Aetiology/Harm Source Type: research
Risk stratification schemes for stroke in atrial fibrillation: the predictive factors still undefined.
Authors: Kosior DA
PMID: 26787631 [PubMed - in process]
Source: Polskie Archiwum Medycyny Wewnetrznej - January 22, 2016 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research
In atrial fibrillation, the ATRIA risk score better predicted stroke than CHADS2 and CHA2DS2-VASc scores.
PMID: 26882308 [PubMed - in process]
Source: Annals of Internal Medicine - February 16, 2016 Category: Internal Medicine Authors: Calenda BW, Granger CB Tags: Ann Intern Med Source Type: research
ISC: Cryptogenic stroke linked to PSVT in absence of atrial fibrillation
LOS ANGELES – Paroxysmal supraventricular tachycardia is associated with subsequent ischemic stroke in patients without documented atrial fibrillation, according to a claims analysis of 42,152...
Source: Internal Medicine News - March 4, 2016 Category: Internal Medicine Source Type: research
Atrial Fibrillation is Associated With Poor Outcomes in Thrombolyzed Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Abstract: The influence of atrial fibrillation (AF) on the clinical outcomes of patients with ischemic stroke (IS) has not been completely determined. We aimed to perform a systematic review and meta-analysis to assess the relationship between AF and adverse events in patients with acute IS treated with thrombolysis.
PubMed, EMBASE, and the Cochrane Library were searched for relevant studies regarding the association between AF and the outcomes of patients with IS treated with thrombolysis. Random and fixed effect models were used for pooling data.
Twelve cohort studies involving 14,801 patients with acute IS were includ...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observ Studies in Epidemiology Source Type: research
AF and stroke may be temporally related
CHICAGO – One-third of a large cohort of patients with an implantable cardiac device in place at the time of an ischemic stroke had one or more episodes of atrial fibrillation within the prior 30...
Source: Internal Medicine News - May 4, 2016 Category: Internal Medicine Source Type: research
Stroke risk rises quickly in recent-onset atrial fib
CHICAGO – The stroke risk in patients with recent-onset atrial fibrillation is similar to that of patients with longer-standing atrial fibrillation, according to a new secondary analysis of the...
Source: Internal Medicine News - May 17, 2016 Category: Internal Medicine Source Type: research
New reversal agent for factor Xa inhibitors shows promise
Commentary on: Siegal DM, Curnette JT, Connolly SJ, et al.. Andexanet alfa for the reversal of Factor Xa inhibitor activity. N Engl J Med 2015;373:2413–24. Context Direct oral anticoagulants (DOACs) have emerged as alternatives to vitamin K-antagonists (eg, warfarin) for the long-term management of stroke prevention for non-valvular atrial fibrillation or venous thromboembolic disease. Favourable side-effect profiles and absence of therapeutic monitoring are important benefits of these newer agents. Warfarin is readily reversed with fresh frozen plasma (FFP) or prothrombin complex concentrates.1 The first reversal ag...
Source: Evidence-Based Medicine - May 22, 2016 Category: Internal Medicine Authors: Ghadimi, K., Welsby, I. J. Tags: Clinical trials (epidemiology), Immunology (including allergy), Drugs: cardiovascular system, Stroke, Venous thromboembolism, Unwanted effects / adverse reactions Therapeutics/Prevention Source Type: research
