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Specialty: Cardiovascular & Thoracic Surgery
Condition: Atrial Fibrillation
Drug: Warfarin

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Total 28 results found since Jan 2013.

Thoracoscopic Ablation With Appendage Ligation Versus Medical Therapy for Stroke Prevention: A Proof-of-Concept Randomized Trial
Conclusions: This small proof-of-concept study showed that TPVIAL improved QOL on two subscores and restored normal sinus rhythm in all but one patient, and it showed the potential to prevent secondary stroke. A larger study will be needed.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - March 1, 2016 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research

Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: a systematic review and network meta-analysis of randomized controlled trials.
CONCLUSIONS: LAA occlusion appears to preserve the benefits of oral anticoagulation therapy for stroke prevention in patients with AF, but the current evidence is of low quality. PMID: 28215062 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 16, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Hanif H, Belley-Cote EP, Alotaibi A, Dvirnik N, Neupane B, Beyene J, Eikelboom JW, Holmes D, Whitlock RP Tags: J Cardiovasc Surg (Torino) Source Type: research

The impact of CHADS2 score on late stroke after the Cox maze procedure
Conclusions: The risk of stroke or transient ischemic attack in patients after a surgical Cox maze procedure was low and not associated with CHADS2 score or warfarin use. Given the known risks of warfarin, we recommend discontinuation of anticoagulation 3 months after the procedure if the patient has no evidence of atrial fibrillation, has discontinued antiarrhythmic medications, and is without any other indication for systemic anticoagulation.
Source: The Journal of Thoracic and Cardiovascular Surgery - July 23, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Mitchell Pet, Jason O. Robertson, Marci Bailey, Tracey J. Guthrie, Marc R. Moon, Jennifer S. Lawton, Andrew Rinne, Ralph J. Damiano, Hersh S. Maniar Tags: Acquired Cardiovascular Disease Source Type: research

Safety of percutaneous left atrial appendage closure with the amplatzer cardiac plug in patients with atrial fibrillation and contraindications to anticoagulation
Conclusion: Percutaneous LAA closure with the ACP in patients with contraindications to oral anticoagulation is safe. The stroke and bleeding risk after percutaneous LAA closure is lower than predicted by conventional risk scores. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - December 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Jens Wiebe, Stefan Bertog, Jennifer Franke, Olga Wettstein, Katharina Lehn, Ilona Hofmann, Laura Vaskelyte, Horst Sievert Tags: Original Study Source Type: research

Evaluation of the efficacy and safety of dual antiplatelet therapy with or without warfarin in patients with a clinical indication for DAPT and chronic anticoagulation: A meta‐analysis of observational studies
Conclusions: All‐cause mortality appears similar in patients treated with TT or DAPT although TT was associated with higher rates of major bleeding and a lower risk for ischemic stroke. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Chirag Bavishi, Anna Koulova, Sripal Bangalore, Ashwin Sawant, Saurav Chatterjee, Sameer Ather, Jose Valencia, Nikolaus Sarafoff, Andrea Rubboli, Juhani K. Airaksinen, Gregory Y. H. Lip, Jacqueline E. Tamis‐Holland Tags: Coronary Artery Disease Source Type: research

Non-Vitamin K Antagonist Oral Anticoagulant vs Warfarin for Post Cardiac Surgery Atrial Fibrillation.
CONCLUSIONS: NOACs are associated with a reduction in post-operative LOS, without excess bleeding or other short-term complications, compared to warfarin. These findings support the broader use of NOACs as a safe alternative to warfarin in patients with post-cardiac surgery AF at elevated stroke risk and acceptable bleeding risk. PMID: 33440173 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - January 10, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Nauffal V, Trinquart L, Osho A, Sundt TM, Lubitz SA, Ellinor PT Tags: Ann Thorac Surg Source Type: research

Left atrial appendage closure: First in man with the 4th generation watchman device
ConclusionsLAA closure with the 4th generation WATCHMAN device is feasible and safe. New technical features may contribute to a better performance of the occluder, particularly regarding the risk of pericardial effusions. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - September 10, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Jakob Ledwoch, Jennifer Franke, Maik Gonzaga, Stefan Bertog, Annkathrin Braut, Ilona Hofmann, Laura Vaskelyte, Sameer Gafoor, Vivek Reddy, Horst Sievert Tags: Valvular and Structural Heart Diseases Source Type: research

Left atrial appendage exclusion: An alternative to anticoagulation in nonvalvular atrial fibrillation
Patients with atrial fibrillation (AF) are 5 times more likely to have a stroke than individuals in sinus rhythm, and 1 in every 5 strokes is secondary to AF.1-3 Unfortunately, AF-related thrombo-emboli are larger and result in ischemic strokes that are more devastating than those secondary to carotid artery disease or other etiologies.4,5 Lifelong oral anticoagulation with warfarin has been the guideline-based therapy to reduce the risk of AF-related ischemic strokes in patients with a CHA2DS2-VASc (congestive heart failure, hypertension, age>75 and diabetes mellitus, previous history of stroke or transient ischemic attac...
Source: The Journal of Thoracic and Cardiovascular Surgery - February 2, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Kareem Bedeir, David R. Holmes, James L. Cox, Basel Ramlawi Tags: Expert review Source Type: research

Residual leaks following percutaneous left atrial appendage occlusion: assessment and management implications.
Authors: Raphael CE, Friedman PA, Saw J, Pislaru SV, Munger TM, Holmes DR Abstract Left atrial appendage (LAA) closure for stroke prevention in the setting of non valvular atrial fibrillation is an alternative to oral anticoagulation in patients with increased bleeding risk. It allows similar reduction in thromboembolic events, in particular stroke, compared to warfarin. A common clinical dilemma is the management of patients with peri-device leak after LAA occlusion. This has been documented in both percutaneous as well as with surgical approaches. The specific definitions of leak severity, and the longer term cli...
Source: EuroIntervention - July 12, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Variation in Warfarin Thromboprophylaxis After Mitral Valve Repair: Does Equipoise Exist and Is a Randomized Trial Warranted?
CONCLUSIONS: At present, half of patients are prescribed warfarin after isolated mitral valve repair in North American cardiac surgical practice which may impact the length of hospital stay. Although patient-level predictors of warfarin prescription exist, center- and surgeon-level variations are prominent. There is a pressing need for a randomized trial both to guide therapy and to ascertain the potential for resource conservation. PMID: 23706423 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 29, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Suri RM, Thourani VH, He X, Brennan JM, O'Brien SM, Rankin JS, Schaff HV, Gammie JS Tags: Ann Thorac Surg Source Type: research

Variation in Warfarin Thromboprophylaxis After Mitral Valve Repair: Does Equipoise Exist and Is a Randomized Trial Warranted? ORIGINAL ARTICLES: ADULT CARDIAC
Conclusions At present, half of patients are prescribed warfarin after isolated mitral valve repair in North American cardiac surgical practice which may impact the length of hospital stay. Although patient-level predictors of warfarin prescription exist, center- and surgeon-level variations are prominent. There is a pressing need for a randomized trial both to guide therapy and to ascertain the potential for resource conservation.
Source: The Annals of Thoracic Surgery - May 29, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Suri, R. M., Thourani, V. H., He, X., Brennan, J. M., O'Brien, S. M., Rankin, J. S., Schaff, H. V., Gammie, J. S. Tags: Valve disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Successful closure of residual leak following LARIAT procedure in a patient with high risk of stroke and hemorrhage.
Abstract Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, California) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel Removed: and effectiveapproach to close a gap following percutaneous LAA suture ligation. © 2013...
Source: Catheterization and Cardiovascular Interventions - October 2, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Research Article Source Type: research

Thromboembolism in a patient with a mechanical mitral valve during anticoagulation with dabigatran etexilate.
We report a 57-year-old man with a mechanical heart valve who experienced acute upper limb thromboembolism during dabigatran intake. Dabigatran might be inadequate for thromboprophylaxis after mechanical valve replacement. PMID: 24182477 [PubMed - in process]
Source: The Annals of Thoracic Surgery - November 1, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kuwauchi S, Watanabe S, Abe K, Yamasaki M, Ito J, Kawazoe K Tags: Ann Thorac Surg Source Type: research

Successful closure of residual leak following lariat procedure in a patient with high risk of stroke and hemorrhage
Percutaneous left atrial appendage suture ligation with the LARIAT® device (Sentre HEART, Redwood City, CA) was successfully performed on an 84‐year‐old woman with non‐valvular atrial fibrillation who developed intracranial hemorrhage on warfarin. However, a large gap developed at follow‐up precluding warfarin cessation. To the best of our knowledge, this case report represents the first description of the use of a Gore® Helex® Septal Occluder (W. L. Gore and Associates, Newark, Delaware) as a novel approach to close a gap following percutaneous LAA suture ligation. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 9, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Wen‐Loong Yeow, Takashi Matsumoto, Saibal Kar Tags: Valvular and Structural Heart Diseases Source Type: research

Long-Term Outcomes of the Maze Procedure Combined With Mitral Valve Repair: Risk of Thromboembolism Without Anticoagulation Therapy
Conclusions Adopting appropriate selection criteria for discontinuing anticoagulation therapy, the majority of patients receiving concomitant mitral repair and the Maze procedure can discontinue warfarin with excellent long-term safety profiles.
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research