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A cost-effectiveness analysis model of Preventicus atrial fibrillation screening from the point of view of statutory health insurance in Germany
ConclusionsThe modelling demonstrates the health benefits and economic effects of an implementation of a systematic screening on AF with “Preventicus Heartbeats”, given the perspective of the German payer, the statutory health care system.
Source: Health Economics Review - June 8, 2020 Category: International Medicine & Public Health Source Type: research

Attitudes toward Anticoagulation for Postoperative Atrial Fibrillation: A Nationwide Survey of VA Providers
ConclusionOur data indicate a wide variability in the management of POAF. This reflects conflicting recommendations in the guidelines, as well as a paucity of prospective treatment trials in this field. Nevertheless, a growing evidence base suggests that this complication carries potentially serious long term morbidity and mortality, and better evidence for its management is needed.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - October 20, 2020 Category: Cardiology Authors: Fady S Riad, Konstantin German, Sarah Deitz, Jayakumar Sahadevan, Varun Sundaram, Albert L Waldo Tags: ELECTROPHYSIOLOGY Source Type: research

Different Risk Profiles of European Patients Using Direct Oral Anticoagulants or Vitamin K Antagonists: a Rapid Review
AbstractPurpose of ReviewWe investigated the risk profiles of patients using direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA) in European cohort studies to estimate the importance of potential (measured or unmeasured) confounding factors in analyses comparing these drugs. We searched MEDLINE and EMBASE (2008 –2018) for relevant studies and extracted information on age, sex, comorbidity, Charlson comorbidity index, HAS-BLED score (assessing risk of bleeding) and CHA2DS2-VASc score (assessing risk of stroke).Recent FindingsOverall, 66 studies with 2,808,757 patients were included. Most patients were from Fr...
Source: Current Epidemiology Reports - November 14, 2020 Category: Epidemiology Source Type: research

Attitudes toward anticoagulation for postoperative atrial fibrillation: A nationwide survey of VA providers
ConclusionOur data indicate a wide variability in the management of POAF. This reflects conflicting recommendations in the guidelines, as well as a paucity of prospective treatment trials in this field. Nevertheless, a growing evidence base suggests that this complication carries potentially serious long ‐term morbidity and mortality, and better evidence for its management is needed.
Source: Pacing and Clinical Electrophysiology : PACE - November 13, 2020 Category: Cardiology Authors: Fady S. Riad, Konstantin German, Sarah Deitz, Jayakumar Sahadevan, Varun Sundaram, Albert L. Waldo Tags: ELECTROPHYSIOLOGY Source Type: research

The impact of basic atrial rhythm during catheter ablation of atrial fibrillation on clinical outcomes: Lessons from the German Ablation Registry
ConclusionBasic atrial rhythm at the time of AF ablation did not affect long ‐term rhythm outcome. For patients suffering from persistent AF a more favorable acute and long‐term safety profile was observed when ablated in SR.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - May 6, 2021 Category: Cardiology Authors: Laura Rottner, Johannes Brachmann, Thorsten Lewalter, Karl ‐Heinz Kuck, Stephan Willems, Lars Eckardt, Matthias Hochadel, Dietrich Andresen, Jochen Senges, Andreas Rillig, Andreas Metzner Tags: ORIGINAL ‐ ELECTROPHYSIOLOGY Source Type: research

Interventional occlusion of left atrial appendage in patients with atrial fibrillation. Gender ‐related outcomes in the German LAARGE Registry
ConclusionLAARGE documented in this elderly patient population undergoing LAAO implantation a higher rate of severe periprocedural complications in females. At 1-year follow-up similar efficacy and safety outcomes were observed for both genders.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - July 27, 2021 Category: Cardiology Authors: Caroline Kleinecke, Thorsten Lewalter, Horst Sievert, Volker Geist, Uwe Zeymer, Harald Mudra, Sven Pleger, Matthias Hochadel, Jochen Senges, Johannes Brachmann Tags: ORIGINAL ARTICLE Source Type: research

Refined atrial fibrillation screening and cost-effectiveness in the German population
Conclusions In our middle-aged population cohort, we identified 0.2% new AF by single timepoint screening. There was a significant estimated risk of stroke and heart failure in these individuals. Cost-effectiveness for screening may be reached in individuals aged 65 years and older. The simple age cut-off is not improved by using Nt-proBNP as a biomarker to guide a screening programme.
Source: Heart - February 24, 2022 Category: Cardiology Authors: Schnabel, R. B., Wallenhorst, C., Engler, D., Blankenberg, S., Pfeiffer, N., Spruenker, N. A., Buettner, M., Michal, M., Lackner, K. J., Münzel, T., Wild, P. S., Martinez, C., Freedman, B., Gutenberg Health Study investigators Tags: Open access Cardiac risk factors and prevention Source Type: research

Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study
CONCLUSION: Among patients with AF, apixaban use was associated with lower risk for GIB and similar rates of ischemic stroke or systemic embolism, ICH, and all-cause mortality compared with dabigatran, edoxaban, and rivaroxaban. This finding was consistent for patients aged 80 years or older and those with chronic kidney disease, who are often underrepresented in clinical trials.PRIMARY FUNDING SOURCE: None.PMID:36315950 | DOI:10.7326/M22-0511
Source: Annals of Internal Medicine - October 31, 2022 Category: Internal Medicine Authors: Wallis C Y Lau Carmen Olga Torre Kenneth K C Man Henry Morgan Stewart Sarah Seager Mui Van Zandt Christian Reich Jing Li Jack Brewster Gregory Y H Lip Aroon D Hingorani Li Wei Ian C K Wong Source Type: research

The association between the body height and cardiovascular diseases: a retrospective analysis of 657,310 outpatients in Germany
ConclusionWe present the first data from a large cohort of outpatients in Germany providing strong evidence for an association between the body height and common CVD. These data should stimulate a discussion as to how far the body height should be implemented as a parameter in stratification tools to assess CVD risk in order to further reduce cardiovascular morbidity and mortality in the future.
Source: European Journal of Medical Research - November 9, 2022 Category: Research Source Type: research

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