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Stroke in systemic lupus erythematosus: epidemiology, mechanism, and long-term outcome.
CONCLUSIONS: The prevalence of stroke in this cohort was 3.1%. Ischemic strokes had a bimodal presentation, occurring either early after SLE diagnosis or after a several-year delay. Half of the hemorrhagic strokes occurred >10 years after the diagnosis of SLE. Clinical outcome was usually good with a relatively low recurrence rate. PMID: 32151182 [PubMed - as supplied by publisher]
Source: Lupus - March 8, 2020 Category: Rheumatology Authors: Guraieb-Chahín P, Cantú-Brito C, Soto-Mota A, Guerrero-Torres L, Flores-Silva F, Chiquete E, Fragoso-Loyo H, González-Duarte A, Valdés-Ferrer SI Tags: Lupus Source Type: research

Stroke in systemic lupus erythematosus and antiphospholipid syndrome: risk factors, clinical manifestations, neuroimaging, and treatment.
This article updates the data regarding the risk factors, clinical manifestations, neuroimaging, and treatment of stroke in SLE and APS. PMID: 28394226 [PubMed - in process]
Source: Lupus - April 1, 2017 Category: Rheumatology Authors: de Amorim LC, Maia FM, Rodrigues CE Tags: Lupus Source Type: research

Stroke is Different in Systemic Lupus Erythematosus: Implications for Survival and Functionality
J Rheumatol. 2021 Mar 1:jrheum.201209. doi: 10.3899/jrheum.201209. Online ahead of print.ABSTRACTUndoubtedly, individuals with systemic lupus erythematosus (SLE) are at higher risk for developing cerebrovascular disease than counterparts from the general population without SLE. In a metaanalysis of studies from around the world, the likelihood of individuals with SLE developing both ischemic and hemorrhagic stroke (intracerebral and/or subarachnoid hemorrhage) was more than 2 times that of the general population1 Risks for stroke appear to be highest soon after SLE diagnosis, and concomitant antiphospholipid syndrome (APS)...
Source: J Rheumatol - March 2, 2021 Category: Rheumatology Authors: Marios Rossides Source Type: research

Lupus, antiphospholipid syndrome, and stroke: An attempt to crossmatch
Lupus. 2023 Mar 20:9612033231165151. doi: 10.1177/09612033231165151. Online ahead of print.ABSTRACTCerebrovascular accidents (CVAs) or strokes are part of the common thrombotic manifestations of Systemic Lupus Erythematosus (SLEs) and Antiphospholipid syndrome (APS). Such neurological thrombotic events tend to occur in patients with SLE at a higher frequency when Antiphospholipid antibodies (aPLs) are present, and tend to involve the large cerebral vessels. The mechanism of stroke in SLE can be driven by complement deposition and neuroinflammation involving the blood-brain barrier although the traditional cardiovascular ri...
Source: Lupus - March 20, 2023 Category: Rheumatology Authors: Georges El Hasbani Imad Uthman Source Type: research

Antiphospholipid antibodies in neonates with stroke--a unique entity or variant of antiphospholipid syndrome?
ConclusionsThe presence of aPL may be important in the pathogenesis of cerebral thrombosis in neonates. Nevertheless, the nature of thrombophilia interactions in this period and their therapeutic impact warrants further investigation. PMID: 24729280 [PubMed - as supplied by publisher]
Source: Lupus - April 11, 2014 Category: Rheumatology Authors: Berkun Y, Simchen M, Strauss T, Menashcu S, Padeh S, Kenet G Tags: Lupus Source Type: research

Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome
Abstract Thrombotic manifestations of antiphospholipid syndrome (APS) are well known, and various non-stroke neuro-psychiatric manifestations (NPMs) have also been consistently described, but their place in APS remains unclear. Some syndromes, such as migraine or cognitive dysfunction, are frequently described in APS, whereas others, like seizure, multiple sclerosis-like symptoms, transverse myelitis, movement disorders, or psychiatric symptoms, are rarely found. Overlap with other autoimmune diseases, in particular with systemic lupus erythematosus, the lack of large sample size prospective studies, and discrepa...
Source: Current Rheumatology Reports - February 29, 2016 Category: Rheumatology Source Type: research

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