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A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
We report an atypical manifestation of immune-mediated thrombotic thrombocytopenic purpura (TTP) that we hypothesize represents a longstanding, or “smoldering,” process. As typified by this case, the prompt recognition and treatment for immune-mediated TTP are often confounded by clinical comorbidities. Thus, TTP should be considered in cases of unremitting thrombocytopenia of unknown origin in patients with stroke or other thrombosis. AbstractPrompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic ...
Source: Clinical Case Reports - October 12, 2021 Category: General Medicine Authors: Mark E. Pepin, Eyad Saca, Soo Y. Kwon, Jori May Tags: CASE REPORT Source Type: research

Tromboc@t Working Group recommendations for management in patients receiving direct oral anticoagulants.
CONCLUSIONS: Progressive increase in the use of DOACs calls for measures to establish and homogenise clinical management guidelines for patients anticoagulated with DOACs in ATUs and PCCs. PMID: 29602444 [PubMed - as supplied by publisher]
Source: Medicina Clinica - April 1, 2018 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Management of ischemic stroke in the hyperacute phase.
Authors: Devos D, Sevin M, De Gaalon S, Lintia-Gaultier A, Guillon B Abstract Over the last 15 years, advances in acute ischemic stroke (AIS) management have led to a significant reduction in the morbidity and mortality related to this serious disease. This has resulted from progress in imaging technology, increased access to imaging procedures, enhanced coordination in stroke care from emergency departments to rehabilitation centers, development of organized inpatient stroke units, and to the widespread use of acute thrombolysis. Once the diagnosis of AIS is confirmed by neuroimaging, the etiological work up is co...
Source: Panminerva Medica - June 4, 2015 Category: Journals (General) Tags: Panminerva Med Source Type: research

Republished: Clinical implications of the Third Universal Definition of Myocardial Infarction
The definition of myocardial infarction (MI) continues to evolve as refined ECG criteria, more advanced imaging, and more sensitive and specific biomarkers are developed. The acceptance globally of a clinically practical standard definition for everyday practice would allow for better comparisons across clinical experiences and further facilitate research in this critical area. Because of the evolution of better diagnostic tools and more information about the value and limitations of previous definitions, there was a need to update the Universal Definition of MI published in 20071 and this has recently been accomplished.2 ...
Source: Postgraduate Medical Journal - August 18, 2014 Category: Journals (General) Authors: White, H. D., Thygesen, K., Alpert, J. S., Jaffe, A. S. Tags: Cardiomyopathy, Drugs: cardiovascular system, Stroke, Interventional cardiology, Ischaemic heart disease, Venous thromboembolism, Radiology, Clinical diagnostic tests, Cardiothoracic surgery, Vascular surgery Republished education in heart Source Type: research