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Specialty: Allergy & Immunology
Condition: Stroke
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Total 746 results found since Jan 2013.
Palmatine, a natural alkaloid, attenuates memory deficits and neuroinflammation in mice submitted to permanent focal cerebral ischemia
Ischemic stroke is one of the major causes of human morbidity and mortality. The pathophysiology of ischemic stroke involves complex events, including oxidative stress and inflammation, that lead to neuronal loss and cognitive deficits. Palmatine (PLT) is a naturally occurring (Coptidis rhizome) isoquinoline alkaloid that belongs to the class of protoberberines and has a wide spectrum of pharmacological and biological effects. In the present study, we evaluated the impact of Palmatine on neuronal damage, memory deficits, and inflammatory response in mice submitted to permanent focal cerebral ischemia induced by middle cere...
Source: Journal of Neuroimmunology - June 17, 2023 Category: Allergy & Immunology Authors: Juliana Fernandes Pereira, Juliana Catharina de Sousa Neves, Analu Arag ão Fonteles, Jéssica Rabelo Bezerra, Rayssa Costa Pires, Ana Thais Araújo da Silva, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Reinaldo Barreto Oriá, Glauce Socorro d Source Type: research
The intestinal γδ T cells: functions in the gut and in the distant organs
Located in the frontline against the largest population of microbiota, the intestinal mucosa of mammals has evolved to become an effective immune system. γδ T cells, a unique T cell subpopulation, are rare in circulation blood and lymphoid tissues, but rich in the intestinal mucosa, particularly in the epithelium. Via rapid production of cytokines and growth factors, intestinal γδ T cells are key contributors to epithelial homeostasis and immune surveillance of infection. Intriguingly, recent studies have revealed that the intestinal γδ T cells may play novel exciting functions ranging from epithelial plasticity and ...
Source: Frontiers in Immunology - June 16, 2023 Category: Allergy & Immunology Source Type: research
Neutrophil percentage to albumin ratio is associated with stroke-associated pneumonia and poor outcome in patients with spontaneous intracerebral hemorrhage
ConclusionHigher NPAR is independently associated with SAP and poor functional outcome in patients with ICH. Our findings suggest that early prediction of SAP is feasible by using a simple biomarker NPAR.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research
Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype
ConclusionOur study highlights the potential of targeting Netrin-1 and its receptors as a promising therapeutic strategy for promoting post-ischemic survival and functional recovery.
Source: Frontiers in Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research
Brainstem Infarction in Immunodeficiency Identified as Adenosine Deaminase 2 Deficiency: Case Report
ConclusionWe present the case of a young adult with diagnosis of DADA2 as a cause for recurrent strokes due to vasculitis. This stroke etiology is rare but should be considered as a cause of recurrent stroke of unknown origin in young patients to avoid a disabling disease course by disease-specific treatment options.
Source: Journal of Clinical Immunology - June 12, 2023 Category: Allergy & Immunology Source Type: research
Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine
DiscussionOur results indicate that the poor prognosis of HS patients correlates with severe coagulation disorders, coagulation abnormalities in HS rats are associated with the damage of EGCX, and NAC improves HS-induced coagulopathy, probably through its protection against EGCX injury by preventing ROS generation.
Source: Frontiers in Immunology - June 6, 2023 Category: Allergy & Immunology Source Type: research
Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort
In conclusion, this cohort describes the clinical, genetic and laboratory findings of 29 Dutch DADA2 patients. We describe the occurrence of HLH as a life-threatening disease complication and report a relatively high incidence of malignancies and mortality.
Source: Journal of Clinical Immunology - June 5, 2023 Category: Allergy & Immunology Source Type: research
Effects of Cooling Interventions with Different Target Temperatures on Heat Stroke Rats
Source: Journal of Inflammation Research - May 31, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Neuroinflammation and peripheral immunity: Focus on ischemic stroke
Int Immunopharmacol. 2023 May 28;120:110332. doi: 10.1016/j.intimp.2023.110332. Online ahead of print.ABSTRACTIschemic stroke (IS) produces a powerful inflammatory cascade in the brain, resulting in the occurrence of neuroinflammation. Neuroinflammation is triggered not only by resident immune cells, but also by neutrophils, macrophages, and T lymphocytes infiltrating the peripheral immune system. The disruption of the blood-brain barrier appears to exacerbate inflammatory infiltrates after IS. In turn, IS also has effects on peripheral immunity, manifested as peripheral immunosuppression syndrome, which increases the risk...
Source: International Immunopharmacology - May 30, 2023 Category: Allergy & Immunology Authors: Huiqing Wang Shenyang Zhang Lili Xie Zhe Zhong Fuling Yan Source Type: research
Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injury
In conclusion, the optimized SBB pretreatment protocol blocks brain section autofluorescence of the three acute brain injury models.
Source: Frontiers in Immunology - May 29, 2023 Category: Allergy & Immunology Source Type: research
Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study
ConclusionThe present study provides supportive evidence that genetic predisposition to levels of certain cytokines causally affects the development of specific type of CVD. These findings have important implications for the creation of novel therapeutic strategies targeting these cytokines as a means of preventing and treating CVD.
Source: Frontiers in Immunology - May 25, 2023 Category: Allergy & Immunology Source Type: research
TREM2, microglial and ischemic stroke
Ischemic stroke (IS) is a leading cause of morbidity and mortality worldwide. Immunity and inflammation are key factors in the pathophysiology of IS. The inflammatory response is involved in all stages of stroke, and microglia are the predominant cells involved in the post-stroke inflammatory response. Resident microglia are the main immune cells of the brain and the first line of defense of the nervous system. After IS, activated microglia can be both advantageous and detrimental to surrounding tissue; they can be divided into the harmful M1 types or the neuro-protective M2 type.
Source: Journal of Neuroimmunology - May 15, 2023 Category: Allergy & Immunology Authors: Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wang Tags: Review Article Source Type: research
BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion
Int Immunopharmacol. 2023 May 10;119:110201. doi: 10.1016/j.intimp.2023.110201. Online ahead of print.ABSTRACTBRG1 is a key factor in the process of apoptosis and oxidative damage; however, its role in the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle cerebral artery occlusion (MCAO) reperfusion in mice, microglia were significantly activated in the cerebral cortex of the infarct area, and BRG1 expression was increased in the mouse MCAO/R model, peaking at 4 days. In microglia subjected to OGD/R, BRG1 expression increased and peaked at 12 h after reoxygenation. After ischemic stroke,...
Source: International Immunopharmacology - May 12, 2023 Category: Allergy & Immunology Authors: Kongwei Guo Yanxing Shang Zhao Wang Yu Li Jinliang Chen Baofeng Zhu Dongmei Zhang Jianrong Chen Source Type: research
Evaluating the comorbidities of age and cigarette smoking on stroke outcomes in the context of anti-complement mitigation strategies
Multiple neuroprotective agents have shown beneficial effects in rodent models of stroke, but they have failed to translate in the clinic. In this perspective, we consider that a likely explanation for this failure, at least in part, is that there has been inadequate assessment of functional outcomes in preclinical stroke models, as well the use of young healthy animals that are not representative of clinical cohorts. Although the impact of older age and cigarette smoking comorbidities on stroke outcomes is well documented clinically, the impact of these (and other) stroke comorbidities on the neuroinflammatory response af...
Source: Frontiers in Immunology - May 8, 2023 Category: Allergy & Immunology Source Type: research
Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway
Ginkgo biloba extract (EGb-761) is well-recognized to have neuroprotective properties. Meanwhile, autophagy machinery is extensively involved in the pathophysiological processes of ischemic stroke. The EGb-761 is widely used in the clinical treatment of stroke patients. However, its neuroprotective mechanisms against ischemic stroke are still not fully understood. The present study was conducted to uncover whether the pharmacological effects of EGb-761 can be executed by modulation of the autophagic/lysosomal signaling axis.
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Authors: Rui Zang, Fayang Ling, Zhiyuan Wu, Jun Sun, Licong Yang, Zuyin Lv, Nengbo Ji Source Type: research
