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The effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy
Medicine (Baltimore). 2023 Aug 25;102(34):e34616. doi: 10.1097/MD.0000000000034616.ABSTRACTButylphthalide can improve blood circulation in patients with acute cerebral infarction. Complement 3a receptor 1 (C3aR1) is involved in the regulation of innate immune response and pathogen monitoring, which is closely related to the pathophysiological processes of breast cancer, neurogenesis and lipid catabolism. Our study explored the therapeutic effect of butylphthalide on improving the neurological function of patients with acute anterior circulation cerebral infarction after mechanical thrombectomy, and evaluated the correlatio...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Xinghua Wang Xinchi Luan Zhigang Yang Source Type: research

Bioinformatic analysis and clinical diagnostic value of hsa_circ_0004099 in acute ischemic stroke
This study investigates the expression and effect of hsa_circ_0004099 in acute ischemic stroke (AIS). We conducted a case-controlled study that included 40 patients with AIS within 24 hours and 40 healthy subjects during the same period as a control group. Differentially expressed circular RNAs (circRNAs) were obtained using GEO2R, and the expression of hsa_circ_0004099 was verified using RT-PCR. Correlation analysis of the National Institutes of Health Stroke Scale (NIHSS) disease severity score and ischemic time with hsa_circ_0004099 expression levels was also performed. The receiver operating characteristic (ROC) curve ...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Jiqing Zheng Shuiming Luo Yaobin Long Source Type: research

Eloquent Lower Grade Gliomas, a Highly Vulnerable Cohort: Assessment of Patients ’ Functional Outcome After Surgery Based on the LoG-Glio Registry
Majority of lower grade glioma (LGG) are located eloquently rendering surgical resection challenging. Aim of our study was to assess rate of permanent deficits and its predisposing risk factors. We retrieved 83 patients harboring an eloquently located LGGs from the prospective LoG-Glio Database. Patients without surgery or incomplete postoperative data were excluded. Sign rank test, explorative correlations by Spearman ρ and multivariable regression for new postoperative deficits were calculated. Eloquent region involved predominantly motor (45%) and language (40%). At first follow up after 3 months permanent neuro-logica...
Source: Frontiers in Oncology - March 3, 2022 Category: Cancer & Oncology Source Type: research

Optic nerve firing may spark growth of vision-threatening childhood tumor
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice, researchers showed how the act of seeing light may trigger the formation of vision-harming tumors in young children who are born with neurofibromatosis type 1 (NF1) cancer predisposition syndrome. The research team, funded by the National Institutes of Health, focused on tumors that grow within the optic nerve, which relays visual signals from the eyes to brain. They discovered that the neural activity which underlies these signals can both ignite and feed the tumors.
Source: EurekAlert! - Cancer - June 1, 2021 Category: Cancer & Oncology Source Type: news

Combination treatment for common glioma type shows promise in mice
(NIH/National Institute of Neurological Disorders and Stroke) Gliomas are common brain tumors that comprise about one third of all cancers of the nervous system. In a study funded by the National Institutes of Health (NIH), researchers tested a novel combination treatment approach on mice with tumors with characteristics similar to human astrocytomas and found tumor regression in 60 percent of the mice treated. These encouraging results could be the first step toward developing a treatment for this type of brain cancer.
Source: EurekAlert! - Cancer - February 16, 2021 Category: Cancer & Oncology Source Type: news

Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body's natural production of alpha-ketoglutarate extended the lives of mice harboring DIPG tumors by slowing the growth of the cancer cells.
Source: EurekAlert! - Cancer - August 18, 2020 Category: Cancer & Oncology Source Type: news

Releasing an immune system brake could help patients with rare but fatal brain infection
(NIH/National Institute of Neurological Disorders and Stroke) The anti-cancer drug pembrolizumab has shown promise in slowing or stopping the progression of progressive multifocal leukoencephalopathy (PML), a typically fatal infection of the brain caused by the JC virus (JCV). This finding comes from a small-scale study by scientists at National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. The study appears in the New England Journal of Medicine.
Source: EurekAlert! - Cancer - April 10, 2019 Category: Cancer & Oncology Source Type: news

Study Confirms There Is No Safe Level of Smoking
By Stacy SimonPeople who smoke as little as 1 cigarette a day over their lifetime still have a greater risk of early death than people who have never smoked, according to a study by researchers from the National Cancer Institute. The researchers say this shows that no level of cigarette smoking is safe.The study included 290,215 adults ages 59 to 82 who answered questions about how many cigarettes they smoked during different periods throughout their lives. Researchers then followed the participants for an average 6.6 years. Results showed that people who consistently smoked an average of less than 1 cigarette per day had ...
Source: American Cancer Society :: News and Features - December 8, 2016 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news

Say Yes to Yoga
By Stacy SimonThe ancient Indian practice of yoga combines meditation, breathing, and precise postures and poses to make a connection with thoughts, body, and spirit. People who practice yoga claim it leads to a state of physical health, relaxation, happiness, peace, and tranquility.Some evidence shows that yoga can lower stress, increase strength, and lessen lower back pain, while providing exercise. And according to a report from the National Institutes of Health, there is also some evidence to suggest yoga may be helpful when used alongside conventional medical treatment to help relieve some of the symptoms linked to ca...
Source: American Cancer Society :: News and Features - September 1, 2016 Category: Cancer & Oncology Tags: Complementary and Alternative Methods Source Type: news

MDI Biological Laboratory receives funds for research on nerve damage
(Mount Desert Island Biological Laboratory) The MDI Biological Laboratory has announced that it has received a grant of $456,500 over two years from the National Institutes of Health (NIH) for the study of peripheral neuropathy. The grant from the National Institute of Neurological Disorders and Stroke will support research conducted by assistant professor Sandra Rieger, Ph.D., on chemotherapy-induced peripheral neuropathy, a disabling condition causing pain, numbness, tingling and temperature sensitivity in the distal extremities.
Source: EurekAlert! - Cancer - August 17, 2016 Category: Cancer & Oncology Source Type: news

DNA repair factor linked to breast cancer may also play a role in Alzheimer's disease
(NIH/National Institute of Neurological Disorders and Stroke) Mutant forms of breast cancer factor 1 are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia. The study was funded by the National Institutes of Health.
Source: EurekAlert! - Cancer - November 30, 2015 Category: Cancer & Oncology Source Type: news

It’s Never Too Late to Quit Smoking
By Stacy SimonAbout half of all Americans who smoke and don’t quit will die because of smoking. That’s one of the reasons it’s so important to quit, and the sooner the better. But quitting is rewarding no matter how old you are or whether you have health problems. Studies show that even after age 80, people can live healthier if they give up cigarettes.And the benefits are almost immediate. Ex-smokers have fewer illnesses such as colds and the flu, lower rates of bronchitis and pneumonia, and feel healthier than people who still smoke. Just 20 minutes after quitting, your heart and blood pressure drop. In...
Source: American Cancer Society :: News and Features - November 16, 2015 Category: Cancer & Oncology Tags: Smoking/Tobacco Source Type: news

Strengthening the immune system's fight against brain cancer
(NIH/National Institute of Neurological Disorders and Stroke) When cancer strikes, it may be possible for patients to fight back with their own defenses, using a strategy known as immunotherapy. According to a new study published in Nature, researchers have found a way to enhance the effects of this therapeutic approach in glioblastoma, a deadly type of brain cancer, and possibly improve patient outcomes. The research was funded by the National Institutes of Health.
Source: EurekAlert! - Cancer - March 19, 2015 Category: Cancer & Oncology Source Type: news