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Targeted brain stimulation 'could aid stroke recovery'
Conclusion This mouse model of stroke has found that stimulating nerve cells in the part of the brain responsible for movement (the primary motor cortex) can lead to better blood flow and the expression of proteins that could promote recovery, as well as leading to functional recovery after stroke. But it remains to be determined whether a similar technique could be used in people who have had a stroke. The mice were genetically modified so nerve cells in the primary motor cortex produced an ion channel that could be activated by light. The nerve cells were then activated using a laser. To use this technique in humans, ...
Source: NHS News Feed - August 19, 2014 Category: Consumer Health News Tags: Neurology Source Type: news

Umbilical Cord Blood Mononuclear Cells for Ex-Vivo Gene Therapy
This study was supported by the grant of Russian Science Foundation No 16-15-00010. Kazan Federal University was supported by the Russian Government Program of Competitive Growth.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Bashirov, F. V., Salafutdinov, I. I., Sokolov, M. E., Izmailov, A. A., Markosyan, V. A., Fadeev, F. O., Rizvanov, A., Islamov, R. I. Tags: 801. Gene Therapy and Transfer Source Type: research

Pain, pain, go away
(University of Texas Medical Branch at Galveston) University of Texas Medical Branch at Galveston researchers have been awarded a five-year, $1.8 million grant by the National Institute of Neurological Disorders and Stroke to apply the techniques of gene therapy to the problem of neuropathic pain -- that is, pain that arises from a malfunction in the nervous system.
Source: EurekAlert! - Medicine and Health - May 20, 2013 Category: Global & Universal Source Type: news

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research