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Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: Interleukin-37 Could be Beneficial
Publication date: Available online 31 January 2018Source: Canadian Journal of DiabetesAuthor(s): Pio Conti, Gianpaolo Ronconi, Spyridon K. Kritas, Alessandro Caraffa, Theoharis C. TheoharidesAbstractMast cells (MCs) promote guest immune responses to parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release highly inflammatory compounds that can provoke serious pathologic signs that can lead to death. MCs generate a number of preformed, de novo synthesized compounds and inflammatory cytokine/chemokine synthesis in response to the high-affinity (Kd=10–10 M) immuno...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: IL-37 Could be Beneficial
Publication date: Available online 31 January 2018 Source:Canadian Journal of Diabetes Author(s): Pio Conti, Gianpaolo Ronconi, Spyridon K. Kritas, Alessandro Caraffa, Theoharis C. Theoharides Mast cells (MCs) promote guest immune response against parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release high inflammatory compounds that can provoke serious pathological signs that can even lead to death. MCs generate a number of pre-formed, de novo synthesized compounds, and inflammatory cytokine/chemokine synthesis in response to the high affinity (Kd=10-10 M) Ig...
Source: Canadian Journal of Diabetes - February 28, 2018 Category: Endocrinology Source Type: research

Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication March 2016 Source Type: research