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Multifunctional Selenium Nanoparticles: Chiral Selectivity of Delivering MDR-siRNA for Reversal of Multidrug Resistance and Real-time Biofluorescence Imaging
Publication date: Available online 8 May 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Qingchang Chen , Qianqian Yu , Yanan Liu , Dhairya Bhavsar , Licong Yang , Xiaofan Ren , Dongdong Sun , Wenjing Zheng , Jie Liu , Lan-mei Chen In this paper, chiral selenium nanoparticles (L-SeNPs/D-SeNPs) modified with a dinuclear Ruthenium (II) complex were used to effectively deliver siRNA targeting the MDR1 gene. In this co-delivery system, the luminescent dinuclear Ruthenium (II) complex was developed to act as a gene carrier and anti-tumor drug, while offering luminescent imaging to follow the intracel...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 9, 2015 Category: Nanotechnology Source Type: research

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma
Multidrug resistance-associated protein 1 (MRP1) overexpression plays a major role in chemoresistance in glioblastoma multiforme (GBM) contributing to its notorious deadly nature. Although MRP1-siRNA transfect...
Source: Journal of Nanobiotechnology - April 13, 2018 Category: Nanotechnology Authors: Wing Yin Tong, Mohammed Alnakhli, Richa Bhardwaj, Sinoula Apostolou, Sougata Sinha, Cara Fraser, Tim Kuchel, Bryone Kuss and Nicolas H. Voelcker Tags: Research Source Type: research

DNA Origami Frameworks Enabled Self ‐Protective siRNA Delivery for Dual Enhancement of Chemo‐Photothermal Combination Therapy
Octahedral DNA origami frameworks (OctDOFs) are constructed for sterically enveloping and efficiently delivering siRNAs for chemo-photothermal combination cancer therapy. The confined space created by this nanoscaffold is able to shield the inward anchored siRNAs from degradative RNases during blood circulation, thus achieved dual sensitization of cancer cells to chemodrugs and hyperthermia. AbstractAlthough chemotherapy and photothermal therapy are widely used to combat cancer, their efficacy is often limited by multidrug resistance. Small interfering RNAs (siRNAs) have ability to suppress the expression of target genes, ...
Source: Small - October 6, 2021 Category: Nanotechnology Authors: Tingting Xu, Sha Yu, Yao Sun, Shaojun Wu, Di Gao, Mingyang Wang, Zhenzhen Wang, Ye Tian, Qianhao Min, Jun ‐Jie Zhu Tags: Research Article Source Type: research

Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative b...
Source: Journal of Nanobiotechnology - February 5, 2023 Category: Nanotechnology Authors: Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen and Peng Cao Tags: Research Source Type: research

Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance
Multidrug resistance (MDR) has been restricting the efficacy of chemotherapy, which mainly include pump resistance and non-pump resistance. In order to fight overall MDR, a novel targeted gene/drug co-deliver ...
Source: Journal of Nanobiotechnology - November 11, 2022 Category: Nanotechnology Authors: Changduo Wang, Zhipeng Li, Ping Xu, Lisa Xu, Shangcong Han and Yong Sun Tags: Research Source Type: research