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Specialty: Neurology
Condition: Patent Foramen Ovale

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Total 305 results found since Jan 2013.

Patent Foramen Ovale and Infarct Volume in Cryptogenic Stroke
Background: The causal relationship between patent foramen ovale (PFO) and stroke is controversial. We hypothesized that if PFO is a pathway of embolic source, there might be a correlation between PFO characteristics (ie, size or extent of shunt) and ischemic lesion burden (ie, infarct volume and number).Methods: From ischemic stroke patients admitted to Asan Medical Center between January 2000 and October 2007, we identified those who had (1) acute ischemic lesion on diffusion-weighted imaging within 5 days of symptom onset and (2) cryptogenic stroke and only PFO detected by transesophageal echocardiography. PFO characte...
Source: Journal of Stroke and Cerebrovascular Diseases - June 7, 2013 Category: Neurology Authors: Jin-Man Jung, Jong-Young Lee, Hye-Jin Kim, Youngrok Do, Sun U. Kwon, Jong S. Kim, Jae-Kwan Song, Dong-Wha Kang Tags: Original Articles Source Type: research

Patent Foramen Ovale Closure in the Setting of Cryptogenic Stroke: A Meta-Analysis of Five Randomized Trials
The clinical benefit of patent foramen ovale (PFO) closure after cryptogenic stroke has been a topic of debate for decades. Recently, 3 randomized controlled trials of PFO closure in patients with cryptogenic stroke demonstrated a significantly reduced risk of recurrent stroke compared with standard medical therapy alone. This meta-analysis was performed to clarify the efficacy of PFO closure for future stroke prevention in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - May 24, 2018 Category: Neurology Authors: Lohit Garg, Affan Haleem, Shweta Varade, Keithan Sivakumar, Mahek Shah, Brijesh Patel, Manyoo Agarwal, Sahil Agrawal, Megan Leary, Bryan Kluck Source Type: research

Cost-Effectiveness Analysis of Percutaneous Patent Foramen Ovale Closure Preventing Secondary Ischemic Stroke in Japan
Cryptogenic ischemic stroke is a type of ischemic stroke for which the mechanism of onset and etiology cannot be explained or specified by any known mechanisms/factors. The possible involvement of patent foramen ovale (PFO) in the etiology of cryptogenic ischemic stroke has been reported.1 It was previously reported that occult atrial fibrillation and PFO were embolic sources that caused cryptogenic ischemic stroke.2 PFO is an opening formed during the course of fetal atrial septum development. Usually, it closes spontaneously after birth; however, PFO remains patent after maturation to adulthood.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2021 Category: Neurology Authors: Sachie Inoue, Ataru Igarashi, Yasuyuki Iguchi, Teiji Akagi Source Type: research

Risk of Stroke in Patients with Patent Foramen Ovale: An Updated Meta-analysis of Observational Studies
Background: Although patent foramen ovale (PFO) is considered to be associated with cryptogenic stroke (CS), there remains an ongoing disputation on this issue because of unstable results from randomized controlled trials. The aim of this study was to reassess the PFO effect on stroke through observational data.Methods: An electronic search of PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) were finished. Only case–control studies and cohort studies in Chinese or English were included in the analysis. Then random-effected meta-analysis models were performed to assess the association between PFO...
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2014 Category: Neurology Authors: Bing Ma, Guangcong Liu, Xin Chen, Jianming Zhang, Yiting Liu, Jingpu Shi Tags: Original Articles Source Type: research

Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke
Conclusion: Both antithrombotic regimens are widely used for secondary stroke prevention in patients with CS and PFO. Radiologic and echocardiographic features were strongly associated with treatment choice, whereas conventional vascular risk factors were not. Prior observational studies are likely to be biased by confounding by indication.
Source: Neurology - November 17, 2014 Category: Neurology Authors: Thaler, D. E., Ruthazer, R., Weimar, C., Serena, J., Mattle, H. P., Nedeltchev, K., Mono, M.-L., Di Angelantonio, E., Elkind, M. S. V., Di Tullio, M. R., Homma, S., Michel, P., Meier, B., Furlan, A. J., Lutz, J. S., Kent, D. M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology ARTICLE Source Type: research

Brief History of Patent Foramen Ovale and Stroke Stroke History
Source: Stroke - January 26, 2015 Category: Neurology Authors: Furlan, A. J. Tags: Embolic stroke Stroke History Source Type: research

Migraine makes the stroke grow faster?
Long associated with increased incidence of stroke,1,2 migraine has been linked with mechanisms involving the vasculature (vasospasm, arterial dissection, endothelial dysfunction, venous thrombosis), heart (patent foramen ovale), and blood (hypercoagulability).3 Since cerebral ischemia can induce cortical spreading depression, the physiologic process underlying aura, migraine with aura may theoretically represent a TIA equivalent in a subset of people. In addition to the heightened occurrence of stroke in migraineurs, a growing body of evidence suggests more dire consequences when stroke occurs, with experiments in mice wi...
Source: Neurology - November 30, 2015 Category: Neurology Authors: Tietjen, G. E., Sacco, S. Tags: Migraine, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences
Conclusions— Prothrombotic blood alterations could be involved in the LAA thrombus formation in patients without documented atrial fibrillation and are associated with increased risk of stroke or transient ischemic attack during follow-up.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Meus, R., Son, M., Sobczyk, D., Undas, A. Tags: Ischemic Stroke Clinical Sciences Source Type: research

The Fragility Index in Randomized Controlled Trials for Patent Foramen Ovale Closure in Cryptogenic Stroke
Background and Purpose: The routine use of percutaneous transcatheter patent foramen ovale closure (PPFOC) to prevent recurrent stroke in patients with cryptogenic stroke is still a matter of debate after completion major randomized controlled trials (RCTs). Methods: The fragility index of RCTs evaluating effect of PPFOC against medial therapy alone in stroke prevention was calculated to assess the robustness of statistically significant findings. Results: Literature search with PubMed identifies 6 RCTs on PPFOC.
Source: Journal of Stroke and Cerebrovascular Diseases - March 15, 2019 Category: Neurology Authors: Mehmet Akif Topcuoglu, Ethem Murat Arsava Source Type: research

Diagnostic and Therapeutic Value of Echocardiography during the Acute Phase of Ischemic Stroke
Conclusions: Echocardiography, as currently practiced in our stroke unit, allows detection of CSE in one patient in five, and leads to change in therapy in half of these cases. Our results suggest that TTE should be used for all patients admitted for IS, and to limit the use of TEE to younger patients.
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2014 Category: Neurology Authors: Marie Gaudron, Isabelle Bonnaud, Aaurélia Ros, Frédéric Patat, Bertrand de Toffol, Bruno Giraudeau, Séverine Debiais Tags: Original Articles Source Type: research

Provoked Right-to-Left Shunt in Patent Foramen Ovale Associates With Ischemic Stroke in Posterior Circulation Brief Reports
Conclusions— The predominance of posterior-circulatory infarction in provoked RLS patients suggests that the Valsalva maneuver may promote RLS and paradoxical embolization to the posterior circulation.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Kim, B. J., Kim, N.-Y., Kang, D.-W., Kim, J. S., Kwon, S. U. Tags: Doppler ultrasound, Transcranial Doppler etc. Brief Reports Source Type: research

Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF
Conclusion: Increasing age and a prolonged PR interval at enrollment were independently associated with an increased AF incidence in CS patients. However, they offered only moderate predictive ability in determining which CS patients had AF detected by the ICM.
Source: Neurology - January 18, 2016 Category: Neurology Authors: Thijs, V. N., Brachmann, J., Morillo, C. A., Passman, R. S., Sanna, T., Bernstein, R. A., Diener, H.-C., Di Lazzaro, V., Rymer, M. M., Hogge, L., Rogers, T. B., Ziegler, P. D., Assar, M. D. Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Risk factors in epidemiology ARTICLE Source Type: research

Closure Versus Medical Therapy for Preventing Recurrent Stroke in Patients With Patent Foramen Ovale and a History of Cryptogenic Stroke or Transient Ischemic Attack Cochrane Corner
Source: Stroke - June 26, 2016 Category: Neurology Authors: Li, J., Liu, J., Liu, M., Zhang, S., Hao, Z., Zhang, J., Zhang, C. Tags: Secondary Prevention, Congenital Heart Disease, Ischemic Stroke Cochrane Corner Source Type: research

New Data Support Patent Foramen Ovale Closure After Stroke Emerging Therapy Critique
Source: Stroke - December 22, 2017 Category: Neurology Authors: Christopher G. Favilla, Steven R. Messe Tags: Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Emerging Therapy Critiques Source Type: research

Letter by Moȷadidi et al Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: Mohammad K. Mojadidi, Muhammad O. Zaman, Nimesh K. Patel Tags: Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research