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Condition: Parkinson's Disease
Nutrition: Calcium
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Total 920 results found since Jan 2013.
Quinpirole inhibits levodopa-induced dyskinesias at structural and behavioral levels: Efficacy negated by co-administration of isradipine
Exp Neurol. 2023 Aug 26:114522. doi: 10.1016/j.expneurol.2023.114522. Online ahead of print.ABSTRACTDopamine depletion associated with parkinsonism induces plastic changes in striatal medium spiny neurons (MSN) that are maladaptive and associated with the emergence of the negative side-effect of standard treatment: the abnormal involuntary movements termed levodopa-induced dyskinesia (LID). Prevention of MSN dendritic spine loss is hypothesized to diminish liability for LID in Parkinson's disease. Blockade of striatal CaV1.3 calcium channels can prevent spine loss and significantly diminish LID in parkinsonian rats. While ...
Source: Experimental Neurology - August 28, 2023 Category: Neurology Authors: Timothy J Collier Lauren Begg Jennifer A Stancati Natosha M Mercado Rhyomi C Sellnow Ivette M Sandoval Caryl E Sortwell Kathy Steece-Collier Source Type: research
Ca < sup > 2+ < /sup > signalling: A common language for organelles crosstalk in Parkinson's disease
Cell Calcium. 2023 Jul 27;115:102783. doi: 10.1016/j.ceca.2023.102783. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disease caused by multifactorial pathogenic mechanisms. Familial PD is linked with genetic mutations in genes whose products are either associated with mitochondrial function or endo-lysosomal pathways. Of note, mitochondria are essential to sustain high energy demanding synaptic activity of neurons and alterations in mitochondrial Ca2+ signaling have been proposed as causal events for neurodegenerative process, although the mechanisms responsible for the selective loss of spe...
Source: Cell Calcium - August 19, 2023 Category: Cytology Authors: Caterina Peggion Lucia Barazzuol Elena Poggio Tito Cal ì Marisa Brini Source Type: research
A Case of Milk-Alkali Syndrome Caused by Diuretic-Induced Alkalosis and Polypharmacy
We report a case of milk-alkali syndrome caused by loop-diuretic-induced alkaline load and polypharmacy in an 85-year-old Japanese woman with multiple comorbidities, including osteoporosis, hypertension, type 2 diabetes, dyslipidemia, and Parkinson's disease. The patient regularly took 14 drugs, including calcium L-aspartate, eldecalcitol, celecoxib, and a fixed-dose combination of losartan and hydrochlorothiazide. Immediately before admission, furosemide was administered for the treatment of edema. The patient presented with chest discomfort, general malaise, and clinical signs of dehydration, hypercalcemia, hypophosphate...
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Naoya Mizutani Ken Goda Tsuneaki Kenzaka Source Type: research
