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Specialty: Anesthesiology
Source: Pain
Condition: Pain
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Total 18 results found since Jan 2013.
Post-stroke shoulder pain: Nociceptive or neuropathic?
Acute rehabilitation after stroke can be adversely affected by complications such as pain in the hemiplegic shoulder. The onset of hemiplegic shoulder pain (HSP) can compromise functional gains, and has been shown to contribute to longer term disability . The first systematic study of the incidence of post-stroke shoulder pain (PSSP) found that 40% of patients were affected during the 3–6months following survival of a stroke . In 25% of patients, pain occurred during the first two weeks after stroke . The prognosis at six months, however, appears to be reasonably good, with 80% of patients reporting improvement or comple...
Source: Pain - November 26, 2012 Category: Anesthesiology Authors: Anthony K.P. Jones, Christopher A. Brown Tags: Commentaries Source Type: research
Inability to self-report pain after a stroke: A population-based study
Summary: The inability to self-report pain after a stroke is less common than previously thought, and is associated with both aphasia and level of consciousness.Abstract: The frequency of not being able to self-report pain after a stroke has not been previously assessed in a population-based sample. We studied the epidemiology of this problem using a cohort of patients hospitalized after a stroke in Olmsted County, Minnesota, from June 1, 2008, to June 1, 2012. Overall, 52 of 388 (13.4%) individuals were unable to provide a meaningful response to either a Faces Pain Scale or Numerical Rating Scale on admission. Inability t...
Source: Pain - April 8, 2013 Category: Anesthesiology Authors: Jonathan H. Smith, Kari L. Bottemiller, Kelly D. Flemming, F. Michael Cutrer, Edythe A. Strand Tags: Research papers Source Type: research
Early evoked pain or dysesthesia is a predictor of central poststroke pain
In conclusion, early evoked pain or dysesthesia is a predictor for CPSP.
Source: Pain - October 6, 2014 Category: Anesthesiology Authors: Henriette Klit, Anne P. Hansen, Ninna S. Marcussen, Nanna B. Finnerup, Troels S. Jensen Tags: Research papers Source Type: research
Neglect-like symptoms in complex regional pain syndrome: Learned nonuse by another name?
The use of the term ‘neglect-like’ to characterise symptoms displayed by patients with complex regional pain syndrome (CRPS) has proved to be provocative. It has provided the stimulus for an ever-increasing number of studies exploring spatial perception in affected patients, with calls for further related studies . Although this work would undoubtedly be of interest, there are perhaps 2 important factors to consider if such studies are undertaken. Firstly, studies that have relied on standard clinical tests typically used to identify spatial neglect after stroke have not confirmed the presence of a related deficit in C...
Source: Pain - November 26, 2012 Category: Anesthesiology Authors: T. David Punt, Laura Cooper, Martin Hey, Mark I. Johnson Tags: Topical review Source Type: research
Neural substrates for poststroke complex regional pain syndrome type I: a retrospective case–control study using voxel-based lesion symptom mapping analysis
Poststroke complex regional pain syndrome (CRPS) is characterized by swelling, pain, and changes in the skin that appear on the affected wrist and hand. In this retrospective study, we analyzed the relationship between poststroke CRPS and the location of stroke lesion. From all patients admitted to our hospital from 2009 to 2019, we recruited 80 patients affected by their first unilateral stroke who met the inclusion/exclusion criteria. Thirty-eight patients diagnosed with CRPS after stroke were assigned to the experimental group according to the “Budapest criteria” adopted by the International Association for the Stud...
Source: Pain - May 21, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research
Dissecting neuropathic from poststroke pain: the white matter within
In this study, we address these issues comparing stroke location in a CPSP group of 35 patients with 2 control groups: 27 patients with CNNP and 27 patients with stroke without pain. Brain MRI images were analyzed by 2 complementary approaches: an exploratory analysis using voxel-wise lesion symptom mapping, to detect significant voxels damaged in CPSP across the whole brain, and a hypothesis-driven, region of interest–based analysis, to replicate previously reported sites involved in CPSP. Odds ratio maps were also calculated to demonstrate the risk for CPSP in each damaged voxel. Our exploratory analysis showed that, b...
Source: Pain - March 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research
Animal models for central poststroke pain: a critical comprehensive review
Abstract: Central poststroke pain (CPSP) is a severe type of neuropathic pain that can develop after stroke and is difficult to treat. Research into its underlying mechanisms and treatment options could benefit from a valid CPSP animal model. Nine different CPSP animal models have been published, but there are relatively few reports on successful reproductions of these models and so far only little advances in the understanding or the management of CPSP have been made relying on these models. In general, the construct validity (similarity in underlying mechanisms) of these CPSP animal models is relatively high, although th...
Source: Pain - December 30, 2016 Category: Anesthesiology Tags: Comprehensive Review Source Type: research
Hemiplegic shoulder pain: Evidence of a neuropathic origin
Summary: An underlying mechanism of hemiplegic shoulder pain might be neuropathic. Thus, treatment for neuropathic pain should be considered when treatment for nociceptive pain fails to provide an adequate solution.Abstract: Hemiplegic shoulder pain (HSP) is common after stroke. Whereas most studies have concentrated on the possible musculoskeletal factors underlying HSP, neuropathic aspects have hardly been studied. Our aim was to explore the possible neuropathic components in HSP, and if identified, whether they are specific to the shoulder or characteristic of the entire affected side. Participants included 30 poststrok...
Source: Pain - November 7, 2012 Category: Anesthesiology Authors: Gabi Zeilig, Michal Rivel, Harold Weingarden, Evgeni Gaidoukov, Ruth Defrin Tags: Research papers Source Type: research
No evidence of a neuropathic origin in hemiplegic shoulder pain
Hemiplegic shoulder pain (HSP) is the most common pain condition after stroke (30% to 40%), with a heavy burden and a challenging treatment . We read with great interest the recent article by Zeilig et al., who explored the pathophysiology of HSP . They compared HSP patients, poststroke patients without HSP (NHSP), and normal control subjects, and on quantitative sensory testing (QST) data, they concluded that HSP has a neuropathic component . Unfortunately, their conclusion is biased by some methodological issues and overstatement of the results.
Source: Pain - March 18, 2013 Category: Anesthesiology Authors: Francesca Magrinelli, Giampietro Zanette, Stefano Tamburin Tags: Letters to the Editor Source Type: research
Headache linked with incidence of metabolic syndrome: Comment on migraine, headache and development of metabolic syndrome: An 11-year follow-up in the HUNT study
A considerable body of evidence from large-population studies has linked migraine, particularly with aura, to somewhat increased risk for stroke, coronary heart disease, and subclinical infarct-like lesions as well as to adverse risk profiles for cardiovascular disease (CVD), including hyperlipidemia, obesity, hypertension, and family history of premature CVD . Although the biological mechanisms remain uncertain, this area of research has importance for public health, especially because both migraine and CVD are common in the general population. Understanding the mechanisms that link migraine with various manifestations of...
Source: Pain - May 17, 2013 Category: Anesthesiology Authors: Jameson D. Voss, Ann I. Scher Tags: Commentaries Source Type: research
Migraine, headache and development of metabolic syndrome: An 11-year follow-up in the Nord-Trøndelag Health Study (HUNT)
This study examined the incidence of metabolic syndrome and its relationship to migraine with and without aura and to nonmigraine headache. In the population-based the Nord-Trøndelag Health Study (HUNT), 19,895 individuals were followed for the development of metabolic syndrome, with a median follow-up time of 11.3years. Headache diagnoses were based on a validated headache questionnaire, and metabolic syndrome was based on a modified version of the National Cholesterol Education Program’s Adult Treatment Panel (ATP) III criteria, using objective anthropometric measurements and blood biochemistry. Using the Poisson regr...
Source: Pain - April 10, 2013 Category: Anesthesiology Authors: Bendik Slagsvold Winsvold, Irene Sandven, Knut Hagen, Mattias Linde, Kristian Midthjell, John-Anker Zwart Tags: Research papers Source Type: research
Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model
Abstract: Approximately 7% to 10% of patients develop a chronic pain syndrome after stroke. This chronic pain condition is called central poststroke pain (CPSP). Recent studies have observed an abnormal increase in the secretion of brain-derived neurotrophic factor (BDNF) in spinal cord tissue after spinal cord injury. An animal model of CPSP was established by an intrathalamus injection of collagenase. Mechanical and thermal allodynia was induced after lesions of the thalamic ventral basal complex in rats. Four weeks after the injection, the number of neurons decreased, the number of astrocytes, microglia, and P2X4 recept...
Source: Pain - June 22, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research
Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials
Minimally important difference (MID) refers to the smallest meaningful difference that carries implications for patient care. Minimally important differences are necessary to help interpret patient-reported pain outcomes in research and clinical practice. The PROMIS pain interference scales were validated across diverse samples; however, more information about their MIDs could improve their interpretability. The purpose of this study was to estimate MIDs for 4 fixed-length PROMIS pain interference scales, including the 6-item Pain Short Form and the 4-, 6-, and 8-item pain interference scales used in the PROMIS profile ins...
Source: Pain - March 27, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research
How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study
Central poststroke pain (CPSP) is a neuropathic pain disorder, the underlying mechanisms of which are not well understood. It has been suggested that stroke-associated loss of inhibitory neurons in the spinothalamic tract causes disinhibition of thalamic neurons, which autonomously generate ectopic nociceptive action potentials responsible for the pain experience. We hypothesized that CPSP is a result of misinterpretation of afferent sensory input by the sensitized neurons within the brain, rather than generated spontaneously by the damaged central nervous system (CNS) neurons. To test this hypothesis, we prospectively rec...
Source: Pain - June 26, 2018 Category: Anesthesiology Tags: Research Paper Source Type: research
Do chronic pain and comorbidities affect brain function in sickle cell patients? A systematic review of neuroimaging and treatment approaches
Sickle cell disease (SCD) is a medical condition in which chronic pain is common and negatively impacts psychosocial function and quality of life. Although the brain mechanisms underlying chronic pain are well studied in other painful conditions, the brain mechanisms underlying chronic pain and the associated psychosocial comorbidities are not well established in SCD. A growing literature demonstrates the effect of treatment of chronic pain, including pharmacological and nonpharmacological treatments, on brain function. The present systematic review aimed to (1) determine the effects of chronic pain and psychosocial comorb...
Source: Pain - August 21, 2019 Category: Anesthesiology Tags: Systematic Reviews and Meta-Analyses Source Type: research
