Do chronic pain and comorbidities affect brain function in sickle cell patients? A systematic review of neuroimaging and treatment approaches

Sickle cell disease (SCD) is a medical condition in which chronic pain is common and negatively impacts psychosocial function and quality of life. Although the brain mechanisms underlying chronic pain are well studied in other painful conditions, the brain mechanisms underlying chronic pain and the associated psychosocial comorbidities are not well established in SCD. A growing literature demonstrates the effect of treatment of chronic pain, including pharmacological and nonpharmacological treatments, on brain function. The present systematic review aimed to (1) determine the effects of chronic pain and psychosocial comorbidities on brain function of patients with SCD; (2) summarize pharmacological and nonpharmacological approaches to treat these symptoms; and (3) identify areas for further investigation of potential beneficial effects of treatments on brain function. Titles were screened using predefined criteria, including SCD, and abstracts and full texts were reviewed by 2 independent reviewers. A total of 1167 SCD articles were identified, and 86 full articles were included covering 3 sections: chronic pain (4 studies), psychosocial comorbidities (11 studies), and pharmacological and nonpharmacological treatments (71 studies). Neuroimaging evidence demonstrates aberrant neural processing related to chronic pain and psychosocial comorbidities in SCD beyond ischemic stroke and cerebral hemorrhage. Although neuroimaging studies show an important role for psychological facto...
Source: Pain - Category: Anesthesiology Tags: Systematic Reviews and Meta-Analyses Source Type: research

Related Links:

Conclusions: the frequencies of infections in maternal-fetal health were considered low, highlighting on syphilis and the presence for sickle cell trait.Resumo Objetivos: estimar a taxa de detec ção de patologias da TPN em papel de filtro nas regiões Sul e Sudoeste do Estado da Bahia, bem como delinear o perfil epidemiológico dessas gestantes, calcular e estimar a taxa de adesão e abrangência de cobertura do Programa. Métodos: estudo descritivo, de agosto 2013 a agosto de 2015, de d ados obtidos do Labimuno/ICS/UFBA. Resultados: foram incluídas 64.743 gestantes; as m&e...
Source: Revista Brasileira de Saude Materno Infantil - Category: Midwifery Source Type: research
Authors: Alshahrani MS Abstract OBJECTIVES: To evaluate the attitudes of pregnant women towards different forms of labor pain relief, preferred methods of pain relief, and the effects of social media on their awareness and knowledge. METHODS: This was a cross-sectional study conducted between April and August 2017 in the Maternity and Children's Hospital, Najran, Saudi Arabia. A total of 416 pregnant women were interviewed and analyzed using IBM Sstatistical Package for Social Sciences version 20 (IBM Corp, Armonk, NY, USA). RESULTS: A total of 62.7% were aware of labor pain. However, 58.7% of the total sam...
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Authors: Hao J, Dong B, Zhang J, Luo Z Abstract OBJECTIVES:   To evaluate whether pre-emptive analgesia is an effective technique to reduce postoperative delirium (PD) in geriatric patients with hip fracture. METHODS: This is a double-blind randomized clinical trial. Ninety elderly patients scheduled for hipfracture surgery at HongHui Hospital, Xi'an Jiaotong University, Xi'an, China  between March 2018 and January 2019 were divided into 2 groups. On arrival at the emergency department, the experimental group (n=44) received ultrasound-guided continuous fascia iliaca compartment block (...
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Hi all, For those doing or have completed a pain fellowship, what is the best way to learn? Are there any great resources/textbooks/videos that are helpful? I am now about 1 month in and although the teaching is good at my program, I feel as though I haven't even touched the tip of the iceberg and am trying to figure out where to go from here. Any advice is greatly appreciated!
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Conditions:   Pain;   Depressive Symptoms;   Frailty;   Aging Intervention:   Behavioral: DAPPER Sponsors:   Johns Hopkins University;   Robert Wood Johnson Foundation;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Headache Disorders, Secondary;   Post-Dural Puncture Headache;   Migraine Disorders;   Back Pain;   Anesthesia Intervention:   Sponsor:   Stanford University Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Endometriosis Intervention:   Dietary Supplement: Meta19.01 Sponsor:   Metagenics Europe Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Opioid-use Disorder;   Opioid Use Disorder, Mild Interventions:   Drug: Buprenorphine;   Drug: Buprenorphine/naloxone Sponsor:   Massachusetts General Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Low-back Pain Intervention:   Device: HeatTens (HV-F311-E) Sponsor:   Vrije Universiteit Brussel Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Shoulder Pain Intervention:   Diagnostic Test: Closed Kinetic Chain Upper Extremity Stability Test Sponsor:   University Hospital, Brest Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Anesthesiology | Brain | Chronic Pain | Hemorrhagic Stroke | Ischemic Stroke | Neurology | Pain | Pain Management | Psychology | Sickle Cell Anemia | Stroke | Study