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E-194 A randomized double-blind placebo-controlled trial of prophylactic antidepressant medication for the prevention of depression post aneurysmal subarachnoid hemorrhage
ConclusionsThe initial results of this ongoing study illustrate the feasibility and challenges of mental health screening and prophylactic randomized treatment in the acute care setting for post-SAH patients. Recruitment has been a challenge in this patient population. Here we describe the trends we see in outcomes at 12-months compared to baseline. These trends suggest that despite clinical improvement there may be an increase in depression and anxiety development one-year post-aSAH.Disclosures J. Keen: None. D. Lim: None. K. Prijoles: None. H. Haughn: None. C. Galang: None. A. Duboysky: None. E. Byun: None. K. Carroll: N...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Keen, J., Lim, D., Prijoles, K., Haughn, H., Galang, C., Duboysky, A., Byun, E., Carroll, K., Kelly, C., Federico, E., Gonzalez, A., Levitt, M., Kim, L. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Use of antidepressants in unipolar depression in the elderly
CONCLUSIONS: Unipolar major depressive episodes in the elderly are frequent and their medicinal treatment has specific features. Knowing the specificities of antidepressant use in the elderly allows to optimize its efficiency and to limit the risk of inappropriate prescription leading to harmful adverse effects.PMID:35153054 | DOI:10.1016/j.encep.2021.11.006
Source: L Encephale - February 14, 2022 Category: Psychiatry Authors: A Pericaud C Straczek F Montastruc M Leboyer A Yrondi C Arbus Source Type: research

Effect of Electroacupuncture on Relieving Central Post-Stroke Pain by Inhibiting Autophagy in the Hippocampus.
CONCLUSION: EA may inhibit autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression and effectively alleviating CPSP. SIGNIFICANCE: Statement Previous studies have found that EA can reduce the expression of NK-1R in damaged rats by inhibition of COX-2 and β-catenin loops, which controls the activation of glial cells in the damaged area and the apoptosis of neuronal cells, and alleviated pain. In the male SD rat model, we evaluated this effect that EA inhibits autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression in the brain tissue. In addition, we assessed expression levels...
Source: Brain Research - January 23, 2020 Category: Neurology Authors: Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB, Li YS, Kevin Zhang W, Li XJ, Tian GH Tags: Brain Res Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Modulatory effect of cilostazol on tramadol-induced behavioral and neurochemical alterations in rats challenged across the forced swim despair test
Publication date: Available online 30 May 2016 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Noha M. Gamil, Yousreya A. Maklad, Maha A.E. Ahmed, Shahira Nofal, Amany A.E. Ahmed Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol is an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline and serotonin reuptake that may contribute to its antidepressant-like effects. Clinically, tramadol is used either alone or in combination with other NSAIDs in the treatmen...
Source: Beni Suef University Journal of Basic and Applied Sciences - May 30, 2016 Category: Science Source Type: research