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Specialty: Genetics & Stem Cells
Condition: Multiple Sclerosis

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Total 25 results found since Jan 2013.

Genetic Etiology Shared by Multiple Sclerosis and Ischemic Stroke
Although dramatic progress has been achieved in the understanding and treatment of multiple sclerosis (MS) and ischemic stroke (IS), more precise and instructive support is required for further research. Recent large-scale genome-wide association studies (GWASs) have already revealed risk variants for IS and MS, but the common genetic etiology between MS and IS remains an unresolved issue. This research was designed to overlapping genes between MS and IS and unmask their transcriptional features. We designed a three-section analysis process. Firstly, we computed gene-based analyses of MS GWAS and IS GWAS data sets by VGEAS...
Source: Frontiers in Genetics - July 2, 2020 Category: Genetics & Stem Cells Source Type: research

Identification of a novel Parkinson's disease locus via stratified genome-wide association study
Conclusions: We discovered and replicated a new locus for Sporadic-PD which had escaped detection in un-stratified GWAS. This demonstrates that by stratifying on a key variable the power gained due to diminished heterogeneity can sometimes outweigh the power lost to reduced sample size. We also detected distinct patterns of disease associations for previously established PD susceptibility genes, which gives an insight to the genetic architecture of the disease and could aid in the selection of appropriate study population for future studies.
Source: BMC Genomics - Latest articles - February 10, 2014 Category: Genetics & Stem Cells Authors: Erin Hill-BurnsWilliam WissemannTaye HamzaStewart FactorCyrus ZabetianHaydeh Payami Source Type: research

Shared Gene Expression between Multiple Sclerosis and Ischemic Stroke.
He Li, Xiaofeng Ma, Pan Cui, Wenjing Lang, Junwei Hao
Source: Frontiers in Genetics - February 11, 2019 Category: Genetics & Stem Cells Source Type: research

Shared Gene Expression Between Multiple Sclerosis and Ischemic Stroke
He Li, Lin Chen, Xiaofeng Ma, Pan Cui, Wenjing Lang, Junwei Hao
Source: Frontiers in Genetics - February 12, 2019 Category: Genetics & Stem Cells Source Type: research

Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.
Abstract Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Matrix metalloproteases act as an interface between host's...
Source: Gene - February 26, 2019 Category: Genetics & Stem Cells Authors: Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN Tags: Gene Source Type: research

Apolipoprotein D.
Abstract ApoD is a 25 to 30 kDa glycosylated protein, member of the lipocalin superfamily. As a transporter of several small hydrophobic molecules, its known biological functions are mostly associated to lipid metabolism and neuroprotection. ApoD is a multi-ligand, multi-function protein that is involved lipid trafficking, food intake, inflammation, antioxidative response and development and in different types of cancers. An important aspect of ApoD's role in lipid metabolism appears to involve the transport of arachidonic acid and the modulation of eicosanoid production and delivery in metabolic tissues. ApoD exp...
Source: Gene - June 14, 2020 Category: Genetics & Stem Cells Authors: Rassart E, Desmarais F, Najyb O, Bergeron KF, Mounier C Tags: Gene Source Type: research

The role of Nrf2 in Neural stem/Progenitors cells: from maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease.
Abstract Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but oxidative stress, inflammation and synaptic dysfunction are main hallmarks. Oxidative stress leads to free radical attack on neural cells which contributes to protein misfolding, glia cell activation, mitochondrial dysfunction, impairment of DNA repair system and subsequently cellular death. ...
Source: Ageing Research Reviews - November 10, 2020 Category: Genetics & Stem Cells Authors: Kahroba H, Ramezani B, Maadi H, Sadeghi MR, Jaberie H, Ramezani F Tags: Ageing Res Rev Source Type: research

GSE156935 Synthetic expansion of brain regulatory T cells effectively prevents neuroinflammatory disease II
Contributor : Adrian ListonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAn adaptive immunological component to neuroinflammatory diseases is increasingly being recognized. The recent identification and characterization of a small population of regulatory T cells (Tregs) resident in the brain allows for the potential therapeutic exploitation. As the most potent known anti-inflammatory mediators, Tregs have the capacity to reduce inflammation and promote tissue repair, with a key limitation being the small number present in brain tissue. Here we demonstrate that transgenic ‘micro-d...
Source: GEO: Gene Expression Omnibus - January 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE153427 Synthetic expansion of brain regulatory T cells effectively prevents neuroinflammatory disease
Contributor : Adrian ListonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAn adaptive immunological component to neuroinflammatory diseases is increasingly being recognized. The recent identification and characterization of a small population of regulatory T cells (Tregs) resident in the brain allows for the potential therapeutic exploitation. As the most potent known anti-inflammatory mediators, Tregs have the capacity to reduce inflammation and promote tissue repair, with a key limitation being the small number present in brain tissue. Here we demonstrate that transgenic ‘micro-d...
Source: GEO: Gene Expression Omnibus - January 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE195617 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies
In this study, we used human induced pluripotent stem cell (hiPSC)-derived embryoid bodies (EB) as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds. Morphology, viability, and differentiation potential were investigated after exposing EBs to folic acid, all-trans-retinoic acid, dexamethasone, and valproic acid for 15 days. The results showed that the compounds differentially repressed cell growth, compromised morphology, and triggered apoptosis in the EBs. Further, transcriptomics was employed to compare subtle temporal changes between treated and untreated c...
Source: GEO: Gene Expression Omnibus - January 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

The Impact of Aerobic and Resistance Training Intensity on Markers of Neuroplasticity In Health and Disease
CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.PMID:35853549 | DOI:10.1016/j.arr.2022.101698
Source: Ageing Research Reviews - July 19, 2022 Category: Genetics & Stem Cells Authors: Tibor Hortob ágyi Tomas Vetrovsky Guilherme Moraes Balbim N árlon Cássio Boa Sorte Silva Andrea Manca Franca Deriu Mia Kolmos Christina Kruuse Teresa Liu-Ambrose Zsolt Rad ák M árk Váczi Hanna Johansson Paulo Cezar Rocha Dos Santos Erika Franz én U Source Type: research

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease
CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.PMID:35853549 | DOI:10.1016/j.arr.2022.101698
Source: Ageing Research Reviews - July 19, 2022 Category: Genetics & Stem Cells Authors: Tibor Hortob ágyi Tomas Vetrovsky Guilherme Moraes Balbim N árlon Cássio Boa Sorte Silva Andrea Manca Franca Deriu Mia Kolmos Christina Kruuse Teresa Liu-Ambrose Zsolt Rad ák M árk Váczi Hanna Johansson Paulo Cezar Rocha Dos Santos Erika Franz én U Source Type: research