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Are stroke-like lesions in Leber's hereditary optic neuropathy mistaken as MS-like cerebral lesions?
Publication date: Available online 21 June 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Josef Finsterer
Source: Multiple Sclerosis and Related Disorders - June 30, 2020 Category: Neurology Source Type: research

Alemtuzumab-induced simultaneous onset of autoimmune haemolytic anaemia, alveolar haemorrhage, nephropathy, and stroke: a case report
Publication date: Available online 22 April 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Muhannad A Alnahdi, Sultan Ibrahim Aljarba, Yaser M Al Malik
Source: Multiple Sclerosis and Related Disorders - April 23, 2020 Category: Neurology Source Type: research

CADASIL as Multiple Sclerosis Mimic: a 48-year-old man with severe leukoencephalopathy and spinal cord involvement.
Publication date: Available online 19 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Francesco Motolese, Mariagrazia Rossi, Emma Gangemi, Anna Bersano, Emma Scelzo, Vincenzo Di Lazzaro, Fioravante CaponeAbstractCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a common cause of inherited stroke in young adults. CADASIL causes extensive white matter T2 hyperintensities at brain MRI, in particular involving anterior-temporal lobes and external capsules; usually, there is no spinal cord involvement. Since CADASIL clinical spectrum is heterogeneous ...
Source: Multiple Sclerosis and Related Disorders - February 19, 2020 Category: Neurology Source Type: research

Treating acute ischemic stroke in a patient with multiple sclerosis: a challenging issue
Publication date: Available online 23 January 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Arturo de Falco, Marta De Simone, Florindo d'Onofrio, Daniele Spitaleri, Fabrizio Antonio de FalcoAbstractMultiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination and neurodegeneration in the central nervous system. Recent studies suggested that patients with MS might have a greater risk of ischaemic stroke (IS). IS treatment with intravenous alteplase (IVA) in MS has rarely been reported. This could be due to the challenging diagnosis between acute IS and MS relapse, considering tha...
Source: Multiple Sclerosis and Related Disorders - January 24, 2020 Category: Neurology Source Type: research

Misdiagnosis of Multiple Sclerosis in a Female Heterozygote with Fabry's Disease
Publication date: Available online 30 January 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Joseph R. BergerAbstractFabry's disease is an X-linked disorder of enzyme alpha-galactosidase A which leads to an accumulation of the glycolipids in lysosomes in vessels and organs. The disorder is rare with an estimated incidence of 1 in 40,000 and disease occurs more rarely in women than men. Paresthesias, hearing loss, and stroke are the typical neurological manifestations. Brain magnetic resonance imaging abnormalities may mimic those seen in multiple sclerosis (MS). Reported here is one of the rarely reported c...
Source: Multiple Sclerosis and Related Disorders - January 31, 2019 Category: Neurology Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Yawning and cortisol levels in multiple sclerosis: potential new diagnostic tool
Publication date: Available online 2 May 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Simon B N Thompson, Alister Coleman, Nicola Williams Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had ...
Source: Multiple Sclerosis and Related Disorders - May 15, 2018 Category: Neurology Source Type: research

Why do people search Wikipedia for information on multiple sclerosis?
Conclusion Wikipedia searches do not reliably reflect its actual epidemiology. Celebrities with MS acting as testimonials might effectively increase public knowledge on MS.
Source: Multiple Sclerosis and Related Disorders - February 5, 2018 Category: Neurology Source Type: research

Symbol Digit Modalities Test adaptation for Magnetic Resonance Imaging environment: a systematic review and meta-analysis
Conclusions The present study allowed the identification of brain areas activated during the performance of the SDMT in healthy subjects, and therefore it will help understanding the differences in brain activation by this task in clinical populations. Moreover, it may guide future studies of therapeutic strategies and interventions in those populations.
Source: Multiple Sclerosis and Related Disorders - January 31, 2018 Category: Neurology Source Type: research

Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient
We described a patient with cocaine abuse who presented with Balo's type acute multifocal leukoencephalopathy. Magnetic Resonance Imaging (MRI) of the brain showed onion like patchy concentric ring enhancement on T1-weighted MRI with gadolinium. Balo's Concentric Sclerosis like radiological findings related to cocaine has not been reported. Levamisole is now frequently used as an ingredient in cocaine and may cause leukoencephalopathy. It is recommended to check urine levamisole levels in patients with cocaine-induced leukoencephalopathy with or without mimicking Balo's Concentric Sclerosis. On the other hand, it is also p...
Source: Multiple Sclerosis and Related Disorders - December 16, 2017 Category: Neurology Source Type: research

Common comorbidities and survival in MS: Risk for stroke, type 1 diabetes and infections
Conclusions Given the high risk for stroke in this MS population and the observed complexity among the coincident common risk factors for circulatory diseases, the high risk for type 1 diabetes and common infections raise a need to recognize patients at risk with these conditions and with the other known risk factors such as metabolic syndrome and smoking. The survival disadvantage related to circulatory diseases observed in general population is true also in MS and should be recognized to reduce the burden of disease and premature mortality in MS. Graphical abstract
Source: Multiple Sclerosis and Related Disorders - November 13, 2017 Category: Neurology Source Type: research

Novel candidate genes of the PARK7 interactome as mediators of apoptosis and acetylation in multiple sclerosis: an in silico analysis
Conclusions Based on our results, novel potential target genes are revealed; these differentially expressed genes regulate epigenetic and apoptotic pathways that may further elucidate underlying mechanisms of autorreactivity in MS.
Source: Multiple Sclerosis and Related Disorders - October 24, 2017 Category: Neurology Source Type: research

Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US department of defense administrative claims database
Conclusions Rates of mortality and several comorbidities are higher in the MS versus non-MS cohort. Early recognition and management of comorbidities may reduce premature mortality and improve quality of life in patients with MS.
Source: Multiple Sclerosis and Related Disorders - August 19, 2015 Category: Neurology Source Type: research