Yawning and cortisol levels in multiple sclerosis: potential new diagnostic tool

Publication date: Available online 2 May 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Simon B N Thompson, Alister Coleman, Nicola Williams Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had been diagnosed with multiple sclerosis. Saliva cortisol samples were collected before and after yawning or after stimuli presentation in the absence of yawning. Hospital Anxiety and Depression Scale, General Health Questionnaire, demographic and health details were collected. Comparisons were made of yawners and non-yawners, healthy volunteers and MS participants. Exclusion criteria: chronic fatigue, diabetes, fibromyalgia, heart condition, high blood pressure, hormone replacement therapy, stroke. Yawners had significant differences between saliva cortisol sample 1 and 2 among healthy participants (p<.007) and MS participants (p<.003). There was significant difference between the healthy versus MS non-yawners (P<.042) but not between yawners (p<.862). These results support the Thompson Cortisol Hypothesis suggesting that cortisol levels are eleva...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

Related Links:

Publication date: Available online 21 July 2018Source: Journal of Molecular BiologyAuthor(s): Michela Miani, Bernat Elvira, Esteban N. GurzovAbstractDiabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diabetes (type 1 and 2) are characterized by pancreatic β-cell dysfunction and, in some cases, loss of β-cell mass causing hyperglycemia due to absolute or relative insulin deficiency. The BCL-2 homology 3 (BH3)-only protein BIM has a wide role in apoptosis induction in cells. In this review, we describe the apoptotic mechanisms mediated by BI...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 21 July 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): Vaibhav Walia, Chanchal Garg, Munish GargAbstractPresent study was carried out to investigate the ‘anxiolytic-like’ effect of pyridoxine in mice. Pyridoxine (90, 180 and 360 mg/kg) was administered by intraperitoneal (i.p.) route to the experimental mice and anxiety-related behavior was evaluated by light and dark box (LDB) and elevated plus maze (EPM) models. Glutamate, GABA and nitrite levels were also determined in the isolated whole brain of mice. It was observed that pyridoxine (180 mg/kg, i.p.) exer...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 21 July 2018Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Tong-Xian Zhang, Hua-Ji Liu, Yu ChenAbstractPhotoluminescent nanomaterials with a high quantum yield (QY) is preferred in many applications. Up to the present date, only a few organo-soluble Au-Ag bimetallic nanoclusters (NCs) have ever reported to exhibit a QY of more than 20%. Herein, ultrabright Au-Ag NCs with a maximum QY of ca. 23.6 % were synthesized with the assistance of mercaptosuccinic acid (MSA) and poly(N-vinylimidazole) (PVIm) through a two-step green route, which was almost two-fol...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
This study supports the view that burnout is associated with a depressive cognitive style.
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 21 July 2018Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): X. Liu, D. Zhang, Y. Liu, X. Sun, Y. Hou, B. Wang, Y. Ren, Y. Zhao, C. Han, C. Cheng, F. Liu, Y. Shi, X. Chen, L. Liu, G. Chen, S. Hong, M. Zhang, D. HuAbstractBackground and aimMany studies have shown increased risk of stroke with greater adiposity as measured by body mass index (BMI), but questions remain about the shape of the dose–response relation. We conducted a systematic review and meta-analysis of prospective studies to clarify the strength and shape of the dose–response relation between B...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: Available online 21 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Omid Mirmosayyeb, Emad Fayyazi, Vahid Shaygannejad, Nafiseh Esmaeil
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsWhile HRQoL at population level is most affected by balance problems, spasticity, and depression in RRMS, the biggest HRQoL losses in PMS are caused by spasticity, paralysis, weakness, and pain. Many symptoms with the largest effects in individuals substantially contribute to the population disease burden.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 21 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Cong Zhao, Tao Liu, Chao Ma, Hongzeng Li, Zhuyi Li, Jun GuoAbstractNeuromyelitis optica (NMO), also known as Devic's disease, is a classical autoimmune disorder of the central nervous system (CNS). The relapsing-remitting disease course contributes to application of a variety of immunosuppressants to prevent further relapses after high-dose methylprednisolone pulse therapy for acute attacks. Azathioprine is one of the most widely used immunosuppressive drugs during the remission stage of NMO due to its good efficacy an...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
(MedPage Today) -- This week's topics include tick-borne illness, late life blood pressure and stroke, a simple ED intervention to reduce suicidality, and fecal occult blood and mortality.
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
More News: Anxiety | Brain | Cardiology | Chronic Fatigue Syndrome | Depression | Diabetes | Endocrinology | Fibromyalgia | Heart | Hormone Replacement Therapy | Hormones | Hospitals | Hypertension | Multiple Sclerosis | Neurology | Stroke