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Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research

Clinical Application of Inferior Alveolar Nerve Block Device for Safe and Secure IANB by Any Operator
Pain Res Manag. 2023 Sep 8;2023:1021918. doi: 10.1155/2023/1021918. eCollection 2023.ABSTRACTThe inferior alveolar nerve block (IANB) is an established technique with a success rate of 60-80%; however, large errors have been reported among operators. Some dentists do not prefer to use IANB because of the risk of complications. Nevertheless, it is a useful technique for pain control, and a secure IANB offers significant benefits to operators and patients. This case series study aimed to investigate the efficacy of the "IANB Device," a nerve block guide for IANB, and the adverse events associated with its use in clinical pra...
Source: Pain Research and Management - September 18, 2023 Category: Anesthesiology Authors: Tomoyasu Noguchi Kento Odaka Ken-Ichi Fukuda Source Type: research

Perioperative Pain Management for Distal Radius Fractures
Orthop Clin North Am. 2023 Oct;54(4):463-470. doi: 10.1016/j.ocl.2023.05.006. Epub 2023 Jun 26.ABSTRACTDistal radius fractures have a high incidence among both young and elderly patients, and in many instances require operative intervention. When operative intervention is employed, adequate pain management is essential to decrease postoperative complications, such as chronic pain and disability, while minimizing the risk of prolonged opioid use and dependence. Strategies to optimize pain management include regional anesthesia, preoperative dosing of medication, multimodal regimens, long-acting selective opioids at the time...
Source: The Orthopedic Clinics of North America - September 17, 2023 Category: Orthopaedics Authors: Nolan Farrell Paul T Greenfield Paul T Rutkowski William Jacob Weller Source Type: research

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics
Drug Des Devel Ther. 2023 Aug 30;17:2639-2655. doi: 10.2147/DDDT.S417051. eCollection 2023.ABSTRACTFrom a clinical perspective, local anesthetics have rather widespread application in regional blockade for surgery, postoperative analgesia, acute/chronic pain control, and even cancer treatments. However, a number of disadvantages are associated with traditional local anesthetic agents as well as routine drug delivery administration ways, such as neurotoxicity, short half-time, and non-sustained release, thereby limiting their application in clinical practice. Successful characterization of drug delivery systems (DDSs) for i...
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: He Ma Zhenxiang Pan Bingjie Lai Chunfang Zan He Liu Source Type: research

Application of Ketamine in Pain Management and the Underlying Mechanism
Pain Res Manag. 2023 Aug 16;2023:1928969. doi: 10.1155/2023/1928969. eCollection 2023.ABSTRACTSince ketamine was approved by the FDA as an intravenous anesthetic, it has been in clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the few intravenous anesthetics with potent analgesic properties. As part of the effort to develop pain management, renewed interest has focused on the use of ketamine for the treatment of acute and chronic pain. Ketamine is commonly used to treat various kinds of chronic pain syndromes and is also applied to control perioperative pain and reduce the consumpt...
Source: Pain Research and Management - August 25, 2023 Category: Anesthesiology Authors: Xiaofan Ma Jia Yan Hong Jiang Source Type: research

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