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Total 270 results found since Jan 2013.

How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you… Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China. I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1 We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004. Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news

Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations : A General Population Cohort Study
CONCLUSION: Among patients with gout, SGLT2is may reduce recurrent flares and gout-primary ED visits and hospitalizations and may provide cardiovascular benefits.PRIMARY FUNDING SOURCE: National Institute of Arthritis and Musculoskeletal and Skin Diseases.PMID:37487215 | DOI:10.7326/M23-0724
Source: Annals of Internal Medicine - July 24, 2023 Category: Internal Medicine Authors: Natalie McCormick Chio Yokose Jie Wei Na Lu Deborah J Wexler J Antonio Avi ña-Zubieta Mary A De Vera Yuqing Zhang Hyon K Choi Source Type: research

Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype
Metabolic syndrome is an accumulation of three or more seemingly benign and relatively common conditions (central obesity, hypertension, raised triglycerides, low HDL-cholesterol, glucose intolerance) that, together, increase the risk of developing serious chronic disease.1 It is estimated that one-quarter of adults worldwide have metabolic syndrome2 — a concerning statistic considering that this population is five times more likely to develop diabetes, and two-to-three times more likely to develop heart disease, stroke, and certain cancers.
Source: Osteoarthritis and Cartilage - June 20, 2023 Category: Rheumatology Authors: Casey L Peiris, Adam G Culvenor Tags: Editorial Source Type: research

Perlecan: A Review of its Role in Neurologic and Musculoskeletal Disease
Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains. The complex structure of perlecan and the interaction it has with its local environment accounts for its various cellular and tissue-related effects, to include cartilage, bone, neural and cardiac development, angiogenesis, and blood brain barrier stability. As perlecan is a key contributor to extracellular matrix health involved in many tissues and processes throughout the body, dysregulation of perlecan has the potential to contribute to various neu...
Source: Frontiers in Physiology - May 30, 2023 Category: Physiology Source Type: research

NIH highlights PET imaging in study of rare bone disease
The U.S. National Institutes of Health (NIH) has highlighted a study featurin...Read more on AuntMinnie.comRelated Reading: NaF-PET shows bone formation in psoriatic arthritis patients PET/MRI provides new insights into knee osteoarthritis NaF-PET reveals aortic wall injuries NaF-PET scans reveal plaque -- and possible risk of stroke Can deep learning monitor lesions on F-18 NaF PET/CT?
Source: AuntMinnie.com Headlines - April 10, 2023 Category: Radiology Source Type: news

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity
by Taylor McFadden, Natasha Gaito, Isabella Carucci, Everett Fletchall, Kayla Farrell, Timothy J. Jarome Obesity is a complex medical condition that is linked to various health complications such as infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for responding to the etiology of this disease. The hypothalamus coordinates many integral activities such as hormone regulation and feed intake and numerous studies have observed altered hypothalamic gene regulation in obesity models. Previously, it was reported that the promoter region of the satiety gene,Pomc, has increased DNA met...
Source: PLoS One - April 10, 2023 Category: Biomedical Science Authors: Taylor McFadden Source Type: research

Burden of disease of chronic pain in Ecuador
CONCLUSIONS: Chronic pain is an important source of burden of disease. It is comparable to other important causes such as headaches, stroke, diabetes and chronic obstructive pulmonary disease, among others. Low back pain, osteoarthritis and other musculoskeletal pain were the biggest contributors given their high prevalence.PMID:36946473 | DOI:10.1080/14737167.2023.2193689
Source: Expert Review of Pharmacoeconomics and Outcomes Research - March 22, 2023 Category: Health Management Authors: Pieralessandro Lasalvia Yaneth Gil-Rojas Diego Rosselli Source Type: research