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Blood Biomarkers as Predictors of Long ‐Term Mortality in COPD
Conclusion: high CRP and neutrophils as well as low eosinophils are predictive of poor COPD prognosis. They also add significant value to prediction models of mortality in COPD. This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - December 11, 2017 Category: Respiratory Medicine Authors: Angelico Mendy, Erick Forno, Theophile Niyonsenga, Janvier Gasana Tags: Original Article Source Type: research

Thromboembolic and hemorrhagic risk stratification in patients with atrial fibrillation. Part I: the thromboembolic risk.
Authors: Abrignani MG, Colivicchi F Abstract Atrial fibrillation, whose prevalence is in constant increase, is associated to a noticeably greater thrombo-embolic risk. Various associated factors, such as older age, arterial hypertension, heart failure, previous cerebrovascular events (stroke and transient ischemic attacks), diabetes mellitus, female sex and vascular diseases determine a further increase of the risk of stroke in patients with atrial fibrillation. Robust evidence exists on the efficacy of traditional anticoagulant oral therapy in the prevention of thrombo-embolic risk in these patients, but fears and...
Source: Monaldi Archives for Chest Disease - December 21, 2015 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Intrauterine endotoxin-induced impairs pulmonary vascular function and right ventricular performance in infant rats and improvement with early vitamin D therapy
High pulmonary vascular resistance (PVR), proximal pulmonary artery (PA) impedance, and right ventricular (RV) afterload due to remodeling contribute to the pathogenesis and severity of pulmonary hypertension (PH). Intra-amniotic exposure to endotoxin (ETX) causes sustained PH and high mortality in rat pups at birth, which are associated with impaired vascular growth and RV hypertrophy in survivors. Treatment of ETX-exposed pups with antenatal vitamin D (vit D) improves survival and lung growth, but the effects of ETX exposure on RV-PA coupling in the neonatal lung are unknown. We hypothesized that intrauterine ETX impairs...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2015 Category: Respiratory Medicine Authors: Mandell, E., Powers, K. N., Harral, J. W., Seedorf, G. J., Hunter, K. S., Abman, S. H., Dodson, R. B. Tags: CALL FOR PAPERS Source Type: research

Intrauterine Endotoxin-Induced Impairs Pulmonary Vascular Function and Right Ventricular Performance in Infant Rats and Improvement with Early Vitamin D Therapy.
Abstract High pulmonary vascular resistance (PVR), proximal pulmonary artery (PA) impedance, and right ventricular (RV) afterload due to remodeling contribute to the pathogenesis and severity of pulmonary hypertension (PH). Intra-amniotic exposure to endotoxin (ETX) causes sustained PH and high mortality in rat pups at birth, which is associated with impaired vascular growth and RV hypertrophy in survivors. Treatment of ETX-exposed pups with antenatal vitamin D (vit D) improves survival and lung growth, but the effects of ETX exposure on RV-PA coupling in the neonatal lung is unknown. We hypothesized that intraute...
Source: Am J Physiol Lung Ce... - October 16, 2015 Category: Respiratory Medicine Authors: Mandell E, Powers KN, Harral JW, Seedorf GJ, Hunter KS, Abman SH, Dodson RB Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research