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Right ventricular size and contractile reserve significantly correlate in patients with pulmonary hypertension
Conclusion: RV and RA area represent valuable and easily accessible indicators of RV pump function during exercise and might therefore be used for non-invasive estimation of right ventricular contractile reserve. CIPeak should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Fischer, L., Benjamin, N., Egenlauf, B., Harutyunova, S., Lorenz, H.-M., Blank, N., Marra, A. M., Nagel, C., Fischer, C., Gruenig, E. Tags: Pulmonary hypertension Source Type: research

Echocardiographic assessment in lowlanders vs. highlanders living above 2500m
Conclusion: Chronic exposure to hypoxia in HL promotes a rise in pulmonary artery pressure and a decreased right heart function compared to LL.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lichtblau, M., Saxer, S., Bader, P., Furian, M., Scheiwiller, P., Mademilov, M., Estebesova, B., Osmonov, B., Marazhapov, N., Sheraliev, U., Sooronbaev, T., Bloch, K., Ulrich, S. Tags: Pulmonary hypertension Source Type: research

Association of obstructive sleep apnea with female infertility - A 13-year nationwide population-based retrospective study
Conclusions: Our study provides a nationwide, population based, 13-year retrospective data demonstrating that OSA patients are at a higher risk of female infertility.Keywords: Obstructive sleep apnea; Female infertility; Taiwan National Health Insurance Research Database; Longitudinal Health Insurance Database
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Wang, I.-D., Tsai, P.-Y., Peng, C.-K., Chung, C.-H., Liu, F.-C., Chang, S.-Y., Chien, W.-C. Tags: Sleep and control of breathing Source Type: research

Rest and exercise pulmonary arterial compliance in patients with pulmonary fibrosis
Conclusion: C correlates with markers of pulmonary vasculopathy. The drop of C from rest to exercise may represent an important factor of functional limitation in PF patients.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Panagiotidou, E., Stanopoulos, I., Papakosta, D., Fouka, E., Akritidou, S., Bagalas, V., Boutou, A., Pitsiou, G. Tags: Pulmonary hypertension Source Type: research

Late Breaking Abstract - Economics burden and healthcare utilization in chronic obstructive pulmonary disease patients with or without sepsis
Conclusions: COPD patients who encountered sepsis were associated with higher economics burden and healthcare utilization.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chen, Y., Wu, H.-F., Fang, W.-F., Chen, H.-C., Lin, C.-Y., Lin, M.-C. Tags: Ethics and economics Source Type: research

Forecasting the association of air quality and health outcomes in Ontario
Conclusions: Positive correlations between AQHI and health outcomes are found in this study which revealed that making the public aware of air pollution using AQHI may be helpful to reduce the impact of air pollution in people living with chronic diseases.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Liang, J., Ge, E., Zhu, J., Mcgihon, R., Terebessy, E., Su, Y., To, T. Tags: Occupational and environmental health Source Type: research

COPD as an additional risk factor for cardiovascular and respiratory events in patients with respiratory viral infection
Conclusion: There is no association between respiratory viral infection and COPD with the development of CVE or RE one year after positive virus PCR, regardless of previous CVRF. Both patients with CVRF without COPD and women with CVRF have more CVE.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Zambrano Chacon, M. D. L. A., Esteban-Lucia, L., Garcia Talavera, C. S., Nieto Roca, L., Venegas Rodriguez, A. M., Fernandez Roblas, R., Pello Lazaro, A. M., Acena Navarro, A., Villar Alvarez, F. Tags: Monitoring airway disease Source Type: research

Late Breaking Abstract - The effect of exercise rehabilitation on cardiac function, measured by cardiac MRI, in patients with pre-capillary pulmonary hypertension
Conclusion: Exercise rehabilitation in pre-capillary PH led to significant improvements in cardiac output, stroke volume and right ventricular ejection fraction (EF). Small numbers limited results. Further work is required to assess long term benefits.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: McGettrick, M., Jayasekera, G., Brewis, M., Church, C., Johnson, M., Mackenzie, A. Tags: Right ventricle Source Type: research

MnTBAP reduces pulmonary vascular remodeling in experimental pulmonary arterial hypertension
Conclusion: MnTBAP treatment can partly reverse RV afterload and pulmonary vascular remodeling in established experimental PAH. Together with the improved cardiac function, MnTBAP may be a promising intervention for PAH.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Sun, X.-Q., Gomez-Puerto, M. C., Schalij, I., Vonk-Noordegraaf, A., De Man, F. S., Ten Dijke, P., Bogaard, H.-J. Tags: Pulmonary hypertension Source Type: research

Predictors of physical activity in pulmonary arterial and chronic thromboembolic pulmonary hypertension
Conclusions: Daily physical activity as steps/day assessed in patients newly diagnosed with PAH/CTEPH did not well correlate with invasive hemodynamics at rest nor during exercise, but very well with the 6MWD. Whether daily activity assessments provide additional information to simple walk distance on risk factor profiles during follow-up in patients with PAH/CTEPH remains to be clarified.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Saxer, S., Lichtblau, M., Berlier, C., Hasler, E., Schwarz, E., Ulrich, S. Tags: Pulmonary hypertension Source Type: research

Impact of PAP in reducing cardiovascular events in OSA patients: a 10-years follow-up
Conclusions: Although AHI presented an immediate and sustained decrease with PAP treatment, only an effective PAP adherence (especially after 24 months) seems to be effective in decreasing CV/CeV events, especially when used for more than 6 years.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Alves Moreira, A. C., Martins, N., Van Zeller, M., Drummond, M. Tags: Sleep and control of breathing Source Type: research

When it all comes down to pressure: right ventricular ejection fraction at cardiac catheterisation
In the present issue of the European Respiratory Journal, Heerdt et al. [1] report on the validation of right ventricularejection fraction (RVEF) calculated from a pressure curve at cardiac catheterisation. This is of great interest as right ventricular (RV) function is the main determinant of symptomatology and outcome in pulmonary hypertension [2], and RVEF accordingly adds significantly to risk stratification in these patients [3]. However, ejection fraction (EF) is a ratio of stroke volume (SV) to end-diastolic volume (EDV), with no pressure in the equation. So, how is it possible to calculate a volume ratio from pressure measurements?
Source: European Respiratory Journal - March 11, 2020 Category: Respiratory Medicine Authors: Naeije, R., Richter, M. J., Vanderpool, R., Tello, K. Tags: Editorials Source Type: research

Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m
The question addressed by the study Chronic exposure to hypoxia increases pulmonary artery pressure (PAP) in highlanders, but the criteria for diagnosis of high-altitude pulmonary hypertension (HAPH) are debated. We assessed cardiac function and PAP in highlanders at 3250 m and explored HAPH prevalence using different definitions. Patients and methods Central Asian highlanders free of overt cardiorespiratory disease, permanently living at 2500–3500 m compared to age-matched lowlanders living <800 m. Participants underwent echocardiography close to their altitude of residence (at 3250 m versus ...
Source: European Respiratory Journal - August 19, 2020 Category: Respiratory Medicine Authors: Lichtblau, M., Saxer, S., Furian, M., Mayer, L., Bader, P. R., Scheiwiller, P. M., Mademilov, M., Sheraliev, U., Tanner, F. C., Sooronbaev, T. M., Bloch, K. E., Ulrich, S. Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research

Relation between respiratory diseases and the development of cardiovascular events in patients with respiratory viral infection
Conclusions: COPD does not seem to be an additional risk factor for the development of CVE in patients with respiratory viral infections. However, patients with CVRF and previous CVE more frequently developed new CVE. Patients with CVRF without COPD developed more CVE.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Zambrano Chacon, M. D. L. A., Esteban-Lucia, L., Izquierdo Perez, A., Nieto Roca, L., Venegas Rodriguez, A. M., Garcia Talavera, C. S., Pello Lazaro, A. M., Acena Navaroo, A., Villar Alvarez, F. Tags: Respiratory infections Source Type: research

Cardiac MRI for Prognosis in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis
Conclusion: LV and RV volumes and RV function can be used to predict the risk of mortality in PAH. A decrease in LV volumes carries a higher risk for mortality than a decline in RV function. RV function and volumes are the strongest CMR predictors of clinical progression.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Alabed, S., Alandejani, F., Shahin, Y., Wild, J., Kiely, D., Swift, A. Tags: Imaging Source Type: research

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