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Brain Bioenergetics in Chronic Hypertension: Risk Factor for Acute Ischemic Stroke
Biochem Pharmacol. 2022 Sep 27:115260. doi: 10.1016/j.bcp.2022.115260. Online ahead of print.ABSTRACTChronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also contributing to determine greater neurological deficits and worse functional outcome when an acute cerebrovascular event would occur. A tight relationship exists between cerebrovascular autoregulation, neuronal activity and brain bioenergetics. In chronic hypertension, progressive adaptations of these processes occur as an attempt to cope with the demanding necessity of brain functions, creating a new steady-state homeostatic cond...
Source: Biochemical Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Authors: Ferrari Federica Villa Roberto Federico Source Type: research

Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke
Biochem Pharmacol. 2022 Sep 28;205:115260. doi: 10.1016/j.bcp.2022.115260. Online ahead of print.ABSTRACTChronic hypertension is one of the key modifiable risk factors for acute ischemic stroke, also contributing to determine greater neurological deficits and worse functional outcome when an acute cerebrovascular event would occur. A tight relationship exists between cerebrovascular autoregulation, neuronal activity and brain bioenergetics. In chronic hypertension, progressive adaptations of these processes occur as an attempt to cope with the demanding necessity of brain functions, creating a new steady-state homeostatic ...
Source: Biochemical Pharmacology - September 30, 2022 Category: Drugs & Pharmacology Authors: Federica Ferrari Roberto Federico Villa Source Type: research

The opposing roles of NO and oxidative stress in cardiovascular disease
Publication date: Available online 15 December 2016 Source:Pharmacological Research Author(s): Rebecca H. Ritchie, Grant R. Drummond, Christopher G. Sobey, T. Michael De Silva, Barbara K. Kemp-Harper Nitric oxide (NO) plays a pivotal role in the maintenance of cardiovascular homeostasis. A reduction in the bioavailability of endogenous NO, manifest as a decrease in the production and/or impaired signaling, is associated with many cardiovascular diseases including hypertension, atherosclerosis, stroke and heart failure. There is substantial evidence that reactive oxygen species (ROS), generated predominantly from NADPH oxi...
Source: Pharmacological Research - December 14, 2016 Category: Drugs & Pharmacology Source Type: research

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research