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Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders.
This article reviews the application of siRNA against CVDs with special emphasis on gene targets in combination with delivery systems such as cationic hydrogels, polyplexes, peptides, liposomes and dendrimers. PMID: 26471319 [PubMed - in process]
Source: Current Pharmaceutical Design - October 18, 2015 Category: Drugs & Pharmacology Authors: Maheshwari R, Tekade M, Sharma PA, Tekade RK Tags: Curr Pharm Des Source Type: research

Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration
Vascul Pharmacol. 2021 Mar 29:106860. doi: 10.1016/j.vph.2021.106860. Online ahead of print.ABSTRACT5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporter and receptors plays important roles in chronic hypoxic pulmonary hypertension (CHPH), which is associated with aberrant reactive oxygen species (ROS) production. NADPH oxidase 4 (NOX4) is one of the major sources of ROS in pulmonary vasculature, and has been implicated in the development of PH. NOX4 generates H2O2, which can activate the transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation and ...
Source: Vascular Pharmacology - April 1, 2021 Category: Drugs & Pharmacology Authors: Jia-Lin Song Si-Yi Zheng Rui-Lan He Long-Xin Gui Mo-Jun Lin James S K Sham Source Type: research

Upregulated ClC3 channels/transporters elicit swelling-activated Cl < sup > - < /sup > currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension
Biol Pharm Bull. 2022 Aug 20. doi: 10.1248/bpb.b22-00513. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by vascular remodeling of the pulmonary artery, which is mainly attributed to the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) comprising the medial layer of pulmonary arteries. The activity of ion channels associated with cytosolic Ca2+ signaling regulates the pathogenesis of PAH. Limited information is currently available on the role of Cl- channels in PASMCs. Therefore, the functional expression of ClC3 channels/transporters was herein investigated i...
Source: Biological and Pharmaceutical Bulletin - August 21, 2022 Category: Drugs & Pharmacology Authors: Taiki Amano Aya Yamamura Moe Fujiwara Seiji Hirai Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research

Tubastatin A Suppresses Renal Fibrosis via Regulation of Epigenetic Histone Modification and Smad3-Dependent Fibrotic Genes.
Abstract Inflammation and fibrosis are implicated in the pathogenesis of hypertensive kidney damage. We previously demonstrated that a nonspecific histone deacetylase (HDAC) inhibitor attenuates cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats, which induces HDAC6 protein and enzymatic activity. However, the HDAC inhibitor's effect and mechanism have not yet been demonstrated. We sought to determine whether an HDAC6-selective inhibitor could treat hypertension and kidney damage in angiotensin II-infused mice. Hypertension was induced by infusion of ANG in mice. Tubastatin A, an HDAC6 selectiv...
Source: Vascular Pharmacology - April 25, 2015 Category: Drugs & Pharmacology Authors: Choi SY, Ryu Y, Kee HJ, Cho SN, Kim GR, Cho JY, Kim HS, Kim IK, Jeong MH Tags: Vascul Pharmacol Source Type: research

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in Human epithelial cells.
In conclusion, we show that TRPC6 channel is pivotal for the activation of CaCC by guanabenz through a α2-adrenergic-independent pathway in human airway epithelial cells. We suggest propose a functional coupling between TRPC6 and CaCC and guanabenz as a potential TRPC6 activator for exploring TRPC6 and CaCC channel functions and corresponding channelopathies. PMID: 26265544 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - August 8, 2015 Category: Drugs & Pharmacology Authors: Bertrand J, Dannhoffer L, Antigny F, Vachel L, Jayle C, Vandebrouck C, Becq F, Norez C Tags: Eur J Pharmacol Source Type: research

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