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Total 140 results found since Jan 2013.
Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation
Eur J Pharmacol. 2021 Jul 9:174321. doi: 10.1016/j.ejphar.2021.174321. Online ahead of print.ABSTRACTDioscin showed various pharmacological effects in our previous studies; however, the effects and mechanisms against lung ischemia/reperfusion injury (LI/RI) have not been reported. Hypoxia/reoxygenation (H/R) models were established using A549 and primary AEC-II cells, while LI/RI models were established in rats and mice. The effects of dioscin on oxidative stress, inflammation and apoptosis in vivo and in vitro were investigated. The mechanisms were investigated focus on dioscin regulating FXR/LKB1 signaling pathway. Diosc...
Source: European Journal of Pharmacology - July 12, 2021 Category: Drugs & Pharmacology Authors: Lile Dong Lianhong Yin Ruomiao Li Lina Xu Youwei Xu Xu Han Yan Qi Source Type: research
Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation
In this study, we treated 6-hydroxydopamine (6-OHDA)-induced model rats and PC12 cells with PTE. The mechanism of action of PTE and ethyl stearate was investigated by western blotting, bisulfite sequencing PCR (BSP), real-time PCR, immunofluorescence and siRNA transfection. PTE effectively upregulated the TH expression and downregulated the alpha-synuclein expression in both the substantia nigra and the striatum of the midbrain in a PD model rat. The PC12 cell model showed that both PTE and its active monomer ethyl stearate significantly promoted TH expression and blocked alpha-synuclein, agreeing with the in vivo results....
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 21, 2021 Category: Drugs & Pharmacology Authors: Sen Ye Jun Zhong Jiapei Huang Lichun Chen Lan Yi Xican Li Jianping Lv Jifei Miao Hui Li Dongfeng Chen Caixia Li Source Type: research
Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy
Acta Pharmacol Sin. 2021 Jun 8. doi: 10.1038/s41401-021-00689-2. Online ahead of print.ABSTRACTTubulointerstitial inflammation plays an important role in the progression of diabetic nephropathy (DN), and tubular epithelial cells (TECs) are crucial promoters of the inflammatory cascade. Exchange protein activated by cAMP (Epac) has been shown to suppress the angiotensin II (Ang-II)-induced release of inflammatory cytokines in tubular cells. However, the role of Epac in TEC-mediated tubulointerstitial inflammation in DN remains unknown. We found that administering the Epac agonist 8-pCPT-2'-O-Me-cAMP (8-O-cAMP) to db/db mice...
Source: Acta Pharmacologica Sinica - June 9, 2021 Category: Drugs & Pharmacology Authors: Wen-Xia Yang Yu Liu Shu-Min Zhang Hua-Fen Wang Yi-Fei Liu Jia-Lu Liu Xiao-Hui Li Meng-Ru Zeng Yu-Zhang Han Fu-You Liu Lin Sun Li Xiao Source Type: research
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy
In this study we investigated the role of FOXO3a in regulating the sensitivity of glioma cells to temozolomide (TMZ) and its relationship with BNIP3-mediated mitophagy. We showed that TMZ dosage-dependently inhibited the viability of human U87, U251, T98G, LN18 and rat C6 glioma cells with IC50 values of 135.75, 128.26, 142.65, 155.73 and 111.60 μM, respectively. In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. TMZ treatment induced intracellular RO...
Source: Acta Pharmacologica Sinica - April 21, 2021 Category: Drugs & Pharmacology Authors: Chuan He Shan Lu Xuan-Zhong Wang Chong-Cheng Wang Lei Wang Shi-Peng Liang Tian-Fei Luo Zhen-Chuan Wang Mei-Hua Piao Guang-Fan Chi Peng-Fei Ge Source Type: research
TNF- α impairs EP4 signaling through the association of TRAF2-GRK2 in primary fibroblast-like synoviocytes
In this study we investigated how TNF-α impairs cAMP homeostasis, particularly clarifying the potential downstream molecules of TNF-α and prostaglandin receptor 4 (EP4) signaling that would interact with each other. Using a cAMP FRET biosensor PM-ICUE3, we demonstrated that TNF-α (20 ng/mL) blocked ONO-4819-triggered EP4 signaling, but not Butaprost-triggered EP2 signaling in normal rat FLSs. We showed that TNF-α (0.02-20 ng/mL) dose-dependently reduced EP4 membrane distribution in normal rat FLS. TNF-α significantly increased TNF receptor 2 (TNFR2) expression and stimulated proliferation in human FLS (hFLS) via ecrui...
Source: Acta Pharmacologica Sinica - April 16, 2021 Category: Drugs & Pharmacology Authors: Yu Tai Bei Huang Pai-Pai Guo Zhen Wang Zheng-Wei Zhou Man-Man Wang Han-Fei Sun Yong Hu Sheng-Lin Xu Ling-Ling Zhang Qing-Tong Wang Wei Wei Source Type: research
The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes.
In conclusion, ellagic acid is an effective skin-whitening agent and might be used as a topical applicant.
PMID: 33545118 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S, Hseu YC Tags: Biochem Pharmacol Source Type: research
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
Conclusion: Empagliflozin improves hepatic steatosis through the AMPK-TET2-autophagy pathway. The use of empagliflozin as a treatment for preventing and treating MAFLD in patients with T2DM warrants further study.
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research
Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway
This study aimed to investigate the effect of AS-IV on TIN and its underlying mechanism. Herein, C57BL/6 mice were treated with tacrolimus and/or AS-IV for 4 weeks, and then the renal function, fibrosis, oxidative stress and p62-Keap1-Nrf2 pathway were evaluated to ascertain the contribution of AS-IV and p62-Keap1-Nrf2 pathway to TIN. Our results demonstrated that AS-IV significantly improved renal function and alleviated tubulointerstitial fibrosis compared with the model group. The expression of fibrosis-related proteins, including TGF-β1, Collagen I and α-SMA, were also decreased by AS-IV. Furthermore, AS-IV relieved ...
Source: Frontiers in Pharmacology - January 18, 2021 Category: Drugs & Pharmacology Source Type: research
