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A Post-Authorization Safety Study of Quetiapine as Antidepressant Treatment in Sweden: Nested Case –Control Analyses of Select Outcomes
ConclusionRisks for all-cause mortality, self-harm and suicide, and stroke in older patients may be higher among patients treated with quetiapine and antidepressant combination therapy.
Source: Drug Safety - December 16, 2019 Category: Drugs & Pharmacology Source Type: research

Addressing the burden of epilepsy: Many unmet needs
Publication date: Available online 4 March 2016 Source:Pharmacological Research Author(s): Ettore Beghi Epilepsy is a heterogeneous clinical condition characterized by recurrent unprovoked seizures, their causes and complications. The incidence, prevalence and mortality of epilepsy vary with age, place and time contributing to a variable extent to the burden of the disease. Diagnostic misclassification may have strong impact on personal and societal reflections of the disease in light of its clinical manifestations and the need for chronic treatment. Epilepsy accounts for a significant proportion of the world’s diseas...
Source: Pharmacological Research - March 6, 2016 Category: Drugs & Pharmacology Source Type: research

Epilepsy, comorbidities and treatments.
CONCLUSION: The coexistence of different medical conditions with epilepsy carries important implications for the assessment of the burden of the disease and the outcome and management of these patients, as they often require long-term antiepileptic drug intake. PMID: 28990527 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - October 9, 2017 Category: Drugs & Pharmacology Authors: Guekht A Tags: Curr Pharm Des Source Type: research

A Systematic Review and Meta-analysis of the Adverse Effects of Levonorgestrel Emergency Oral Contraceptive
ConclusionsThe most common adverse effects of levonorgestrel were not serious. This systematic review shows that data regarding the adverse reactions of repeated use of levonorgestrel are scarce. Studies on the multiple uses of levonorgestrel emergency contraception are still required to ensure its safety.
Source: Clinical Drug Investigation - March 10, 2020 Category: Drugs & Pharmacology Source Type: research