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Tuberous sclerosis presenting with hemorrhagic stroke.
Abstract BACKGROUND: Incidence of intracerebral hemorrhage in patients with tuberous sclerosis is rare, and in most of the cases it is associated with either underlying cerebrovascular malformation or hemorrhage into the subependymal giant cell astrocytoma. CASE CHARACTERISTICS: A 2-year-old boy presented with a hemorrhagic stroke, and subsequently diagnosed as a case of tuberous sclerosis. OBSERVATION: Detailed work-up for stroke did not reveal any definite etiology. OUTCOME: Weakness gradually improved. Follow-up neuroimaging showed resolution of hemorrhage. MESSAGE: Clinician must be aware r...
Source: Indian Pediatrics - April 8, 2014 Category: Pediatrics Authors: Purkait R, Bhattacharya S, Roy B, Bhadra R Tags: Indian Pediatr Source Type: research

Malignant Paraganglioma Presenting With Hemorrhagic Stroke in a Child
We report here the case of a 12-year-old boy with malignant sympathetic paraganglioma presenting with hemorrhagic stroke. Severe hypertension was found and the patient evolved into a coma. Brain computed tomography scan showed right thalamus hemorrhage with intraventricular extension. After clinical improvement, further investigation revealed elevated catecholamine and metanephrine levels, and 2 abdominal tumors were identified by computed tomography. Resection of both lesions was performed, and histologic findings were consistent with paraganglioma. Multiple metastatic involvement of bones and soft tissues appeared severa...
Source: PEDIATRICS - December 2, 2013 Category: Pediatrics Authors: Luiz, H. V., da Silva, T. N., Pereira, B. D., Santos, J. G., Goncalves, D., Manita, I., Portugal, J. Tags: Case Report Source Type: research

Changes in Cardiac Function and Cerebral Blood Flow in Relation to Peri/Intraventricular Hemorrhage in Extremely Preterm Infants
Conclusions: Cardiac function and CBF remain stable in very preterm neonates who do not develop P/IVH during the first 3 postnatal days. In very preterm neonates developing P/IVH during this period, lower systemic perfusion and CBF followed by an increase in these variables precede the development of P/IVH. Monitoring cardiac function and cerebral rSO2 may identify infants at higher risk for developing P/IVH before the bleeding occurs.
Source: The Journal of Pediatrics - November 1, 2013 Category: Pediatrics Authors: Shahab Noori, Michael McCoy, Michael P. Anderson, Faridali Ramji, Istvan Seri Tags: Original Articles Source Type: research

How to use... lupus anticoagulants
Introduction Lupus anticoagulants (LA) were first detected in patients with systemic lupus erythematosus (SLE) in 1952 by Conley and Hartmann.1 They identified patients in whom the activated partial thromboplastin time (APTT) was prolonged and which did not correct on the addition of normal plasma. Although Conley and Hartmann's original description was in association with a haemorrhagic disorder, subsequent reports from the 1960s highlighted patients with thrombotic events in the presence of LA.2 The term ‘lupus anticoagulant’ was introduced by Feinstein and Rapaport in 1972.3 It has, however, caused some conf...
Source: Archives of Disease in Childhood - Education and Practice - March 14, 2013 Category: Pediatrics Authors: Sen, E. S., Beresford, M. W., Avcin, T., Ramanan, A. V. Tags: Liver disease, Immunology (including allergy), Hepatitis and other GI infections, Travel medicine, Epilepsy and seizures, Headache (including migraine), Stroke, Pregnancy, Reproductive medicine, Rheumatology Interpretations Source Type: research

Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke
Conclusion: Arteriopathy and coagulation activation are highly prevalent in the acute period of childhood AIS. Although recurrent AIS and intracranial hemorrhage were infrequent in our cohort, one-half of children experienced a poor neurologic outcome at 1 year, the risk of which was increased by acute arteriopathy. Substantiation of these findings in multi-institutional cohort studies is warranted, toward risk stratification in childhood-onset AIS.
Source: The Journal of Pediatrics - December 20, 2012 Category: Pediatrics Authors: Neil A. Goldenberg, Sarah Jenkins, Jessica Jack, Jennifer Armstrong-Wells, Laura Z. Fenton, Nicholas V. Stence, Joyce Oleszek, Richard Boada, Greta N. Wilkening, Charles Wilkinson, Jennifer B. Soep, Shelley D. Miyamoto, Lalit Bajaj, Peter M. Mourani, Mari Tags: Original Articles Source Type: research

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