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Specialty: Transplant Surgery
Condition: Hemorrhagic Stroke

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Total 54 results found since Jan 2013.

Prolonged Corrected QT Interval in the Donor Heart: Is There a Risk?
ConclusionQTc > 500 msec in the donor heart appears to be an independent risk factor for the development of early CAV after heart transplantation possibly due to a higher immunological risk.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - May 1, 2017 Category: Transplant Surgery Authors: Derek Leong, Tamar Aintablian, Michelle Kittleson, Michael Olymbios, Jignesh Patel, David H. Chang, Jon Kobashigawa Tags: Original Article Source Type: research

SANGUINATE (PEGylated Carboxyhemoglobin Bovine): Mechanism of Action and Clinical Update
Abstract Historically, blood substitutes were under development that would provide oxygen carrying capacity as well as fluid replacement for both trauma and surgical indications. Their development was halted by the inability of the products to deliver therapeutic amounts of oxygen targeted to hypoxic tissue as well as from the inherent toxicity of the molecules. This led to the concept of an oxygen therapeutic that would be targeted for indications caused by anemia/ischemia/hypoxia but would not exhibit the toxicity that plagued earlier products. The complex pathophysiology of diseases such as sickle cell and hemorrhagic s...
Source: Artificial Organs - April 11, 2017 Category: Transplant Surgery Authors: Abraham Abuchowski Tags: Main Text Article Source Type: research

HVAD Leads to Fewer Hemorrhagic Strokes Than HeartMate II HVAD Leads to Fewer Hemorrhagic Strokes Than HeartMate II
This study ' will hammer home the importance of managing blood pressure, ' said one expert, but ' a 15% stroke rate is probably still unacceptable in our patient population, ' said another.Medscape Medical News
Source: Medscape Transplantation Headlines - April 7, 2017 Category: Transplant Surgery Tags: Transplantation News Source Type: news

Management of RVAD Thrombosis in Biventricular HVAD Supported Patients
Pump thrombosis confers significant morbidity and mortality in left ventricular assist device (LVAD) supported patients. Particularly in HVAD, therapeutic approaches including thrombolysis, or adjusting anticoagulation have been recommended as initial treatment but are associated with hemorrhagic stroke and death. Conversely, device exchange has been recommended as a preferred choice with low morbidity-mortality. Biventricular support (BIVAD) utilizing 2 HVAD systems has been proven as a novel way to manage critically ill individuals with biventricular failure.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: J. Silva Enciso, M. Brambatti, H. Tran, G.V. Pretorius, E. Adler Source Type: research

Risk Factors, Mortality and Timing of Ischemic and Hemorrhagic Stroke with Left Ventricular Assist Devices
Stroke is a major cause of mortality following left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices
Stroke is a major cause of mortality after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Challenges managing end ‐stage renal disease and kidney transplantation in a child with MTFMT mutation and moyamoya disease
We describe a four‐yr‐old female with features of moyamoya disease referred to our center for kidney transplant evaluation with ESRD secondary to presumed renal dysplasia along with concern for cerebral vascular anomalies. With her constellation of organ involvement, a genetic workup revealed a homozygous, frameshift mutation in the mitochondrial methionyl‐tRNA formyltransferase gene. Given her vascular anomalies and evidence of prior infarcts seen on cerebral imaging, it was felt that her risk of future stroke events was high and that hypotension or intravascular volume depletion would further exacerbate this risk. ...
Source: Pediatric Transplantation - July 7, 2016 Category: Transplant Surgery Authors: Aris Oates, Jessica Brennan, Anne Slavotinek, Adnan Alsadah, Daniel Chow, Marsha M. Lee Tags: Case Report Source Type: research

Challenges managing end‐stage renal disease and kidney transplantation in a child with MTFMT mutation and moyamoya disease
We describe a four‐yr‐old female with features of moyamoya disease referred to our center for kidney transplant evaluation with ESRD secondary to presumed renal dysplasia along with concern for cerebral vascular anomalies. With her constellation of organ involvement, a genetic workup revealed a homozygous, frameshift mutation in the mitochondrial methionyl‐tRNA formyltransferase gene. Given her vascular anomalies and evidence of prior infarcts seen on cerebral imaging, it was felt that her risk of future stroke events was high and that hypotension or intravascular volume depletion would further exacerbate this risk. ...
Source: Pediatric Transplantation - July 7, 2016 Category: Transplant Surgery Authors: Aris Oates, Jessica Brennan, Anne Slavotinek, Adnan Alsadah, Daniel Chow, Marsha M. Lee Tags: Case Report Source Type: research

Using an Integrated ‐Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death
In an era where we are becoming more reliant on vulnerable kidneys for transplantation from older donors, there is an urgent need to understand how brain death leads to kidney dysfunction and, hence, how this can be prevented. Using a rodent model of hemorrhagic stroke and next‐generation proteomic and metabolomic technologies, we aimed to delineate which key cellular processes are perturbed in the kidney after brain death. Pathway analysis of the proteomic signature of kidneys from brain‐dead donors revealed large‐scale changes in mitochondrial proteins that were associated with altered mitochondrial activity and mo...
Source: American Journal of Transplantation - March 10, 2016 Category: Transplant Surgery Authors: M. Z. Akhtar, H. Huang, M. Kaisar, M. L. Lo Faro, R. Rebolledo, K. Morten, L. C. Heather, A. Dona, H. G. Leuvenink, S. V. Fuggle, B. M. Kessler, C. W. Pugh, R. J. Ploeg Tags: Original Article Source Type: research

Using an integrated –omics approach to identify key cellular processes that are disturbed in the kidney following brain death
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - November 25, 2015 Category: Transplant Surgery Authors: Mohammed Z Akhtar, Honglei Huang, Maria Kaisar, Maria Letizia Lo Faro, Rolando Robolledo, Karl Morten, Lisa C Heather, Anthony Dona, Henri G Leuvenink, Susan V Fuggle, Benedict M Kessler, Christopher W Pugh, Rutger J Ploeg Tags: Original Article Source Type: research

Neurological complications in renal transplant patients: A single-center experience
Conclusion We conclude that complications involving the neurological system occur in 10.5% of all transplant patients with 8% involving CNS and 7% involving the PNS. The high mortality rates associated with CNS complications warrant early diagnosis and aggressive treatment in renal transplant recipients.
Source: Indian Journal of Transplantation - November 24, 2015 Category: Transplant Surgery Source Type: research

Clinical Outcomes of Patients Treated With Pulmonary Vasodilators Early and in High Dose After Left Ventricular Assist Device Implantation
Abstract Right ventricular failure (RVF) is common after left ventricular assist device (LVAD) implantation and a major determinant of adverse outcomes. Optimal perioperative right ventricular (RV) management is not well defined. We evaluated the use of pulmonary vasodilator therapy during LVAD implantation. We performed a retrospective analysis of continuous‐flow LVAD implants and pulmonary vasodilator use at our institution between September 2004 and June 2013. Preoperative RVF risk was assessed using recognized variables. Sixty‐five patients (80% men, 50 ± 14 years) were included: 52% HeartWare ventricular assi...
Source: Artificial Organs - May 1, 2015 Category: Transplant Surgery Authors: Christopher Critoph, Gillian Green, Helen Hayes, Jay Baumwol, Kaitlyn Lam, Robert Larbalestier, Sharon Chih Tags: Thoughts and Progress Source Type: research

CHA2DS2-Vasc and HAS-BLED Scores as Predictors of Ischemic and Hemorrhagic Stroke Risk After Left Ventricular Assist Device Implantation
CHA2DS2-VASc score predicts thromboembolic event risk and HAS-BLED score predicts major bleeding risk in patients on anticoagulation with atrial fibrillation. We aimed to evaluate if these scoring systems would be predictive of ischemic stroke and intracranial bleeding complications following continuous-flow left ventricular assist device (CF-LVAD) implantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: H.S. Kemal, S. Ertugay, S. Nalbantgil, M. Zoghi, C. Engin, T. Yagdi, M. Ozbaran Source Type: research

Anticoagulation Reversal With 4-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Patients With Acute Hemorrhagic Stroke
Anticoagulation reversal in patients with left ventricular assist devices (LVAD) after acute hemorrhagic stroke must occur rapidly to prevent hemorrhage expansion and limit neurologic sequelae, keeping in mind the risk of thrombotic complications. The purpose of this study was to report a case series of our initial experience using a recently FDA approved (April 2013) 4-factor prothrombin complex concentrate (4F-PCC) for INR normalization after acute hemorrhagic stroke in LVAD patients, and compare the results with traditional INR reversal agents.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: P. Chen, J. Falvey, L. Lowenstein, A. Miranpuri, W. Hallinan, T. Massey Source Type: research

Left Ventricular Assist Devices vs. the Total Artificial Heart: Which Causes More Cerebrovascular Accidents?
More recently, the continuous flow left ventricular assist devices (LVADs) have been more commonly used in patients (pts) with severe left heart failure. However, these devices also have risk for strokes, both ischemic and hemorrhagic. The Total Artificial Heart (TAH) has also been used in patients with biventricular heart failure at our single institution. Both continuous flow LVADs and TAH patients are systemically anti-coagulated with warfarin and aspirin. We sought to compare stroke rates between the LVAD patients and TAH pts.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: C. Runyan, F. Arabia, L. Czer, M. Kittleson, E. Passano, F. Liou, J. Yabuno, H. Henry, D.H. Chang, J. Kobashigawa, J. Moriguchi Source Type: research