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Evidence-Based Contraception: Common Questions and Answers
Am Fam Physician. 2022 Sep;106(3):251-259.ABSTRACTPrimary care clinicians are uniquely situated to reduce unintended pregnancy in the context of a patient's medical comorbidities, social circumstance, and gender identity. New evidence regarding contraception use has emerged in recent years. The copper intrauterine device is the most effective option for emergency contraception, with similar effectiveness found for the levonorgestrel-releasing intrauterine system, 52 mg, and both offer extended future contraception. Ulipristal given within 120 hours after unprotected intercourse is the most effective oral emergency contrace...
Source: American Family Physician - September 20, 2022 Category: Primary Care Authors: Scott L Paradise Corinne A Landis David A Klein Source Type: research

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM < sub > 2.5 < /sub > , BC, NO < sub > 2 < /sub > , and O < sub > 3 < /sub > : An Analysis of European Cohorts in the ELAPSE Project
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and BC was positively associated with natural-cause and cause-specific mortality in the pooled cohort and the administrative cohorts. Associations were found well below current limit values and guidelines for PM2.5 and NO2. Associations tended to be supralinear, with steeper slopes at low exposures with no indication of a threshold. Two-pollutant models documented the importance of characterizing the ambient mixture with both NO2 and PM2.5. We mostly found negative associations with O3. In two-pollutant models with NO2, the negative associations with O3 were attenuated to esse...
Source: Cancer Control - September 15, 2022 Category: Cancer & Oncology Authors: Brunekreef Bert Strak Maciej Chen Jie J Andersen Zorana Atkinson Richard Bauwelinck Mariska Bellander Tom Boutron Marie-Christine Brandt J ørgen Carey Iain Cesaroni Giulia Forastiere Francesco Fecht Daniela Gulliver John Hertel Ole Hoffmann Barbara de Ho Source Type: research

Urinary element profiles and associations with cardiometabolic diseases: A cross-sectional study across ten areas in China
CONCLUSION: In China, the urinary levels of several toxic metals were significantly associated with the consumption of specific food groups and the risk of cardiometabolic diseases including diabetes and stroke.PMID:34896320 | DOI:10.1016/j.envres.2021.112535
Source: Environmental Research - December 13, 2021 Category: Environmental Health Authors: Lijiao Xu Yunan Liu Qianyu Zhao Huaidong Du Ying Gao Meijuan Bai Jun Lv Yu Guo Liming Li Liang Sun Xu Lin Zhengming Chen Yan Chen Geng Zong Source Type: research

Cytochrome c oxidase ‐modulatory near‐infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury
AbstractNear ‐infrared light (IRL) has been evaluated as a therapeutic for a variety of pathological conditions, including ischemia/reperfusion injury of the brain, which can be caused by an ischemic stroke or cardiac arrest. Strategies have focused on modulating the activity of mitochondrial electron transpor t chain (ETC) enzyme cytochromec oxidase (COX), which has copper centers that broadly absorb IRL between 700 and 1,000  nm. We have recently identified specific COX‐inhibitory IRL wavelengths that are profoundly neuroprotective in rodent models of brain ischemia/reperfusion through the following mechanism: COX ...
Source: IUBMB Life - November 9, 2020 Category: Research Authors: Paul T. Morse, Dennis J. Goebel, Junmei Wan, Samuel Tuck, Lara Hakim, Charlotte L. H üttemann, Moh H. Malek, Icksoo Lee, Thomas H. Sanderson, Maik Hüttemann Tags: RESEARCH COMMUNICATION Source Type: research

Clinical Manifestations of Copper Deficiency: A Case Report and Review of the Literature.
CONCLUSIONS: Our patient presented with copper deficiency secondary to malabsoprtion. This case highlights the importance of copper testing in the bariatric surgery population and in patients with short-bowel syndrome. Given the irreversible nature of neurological symptoms when compared with the expense of nutrition supplements, routine copper testing should be considered in patients with malabsorptive states or altered anatomy, regardless of initial presentation. PMID: 33037701 [PubMed - as supplied by publisher]
Source: Nutrition in Clinical Practice - October 9, 2020 Category: Nutrition Authors: Moon N, Aryan M, Westerveld D, Nathoo S, Glover S, Kamel AY Tags: Nutr Clin Pract Source Type: research

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