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A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
Conclusions -Taken together, our data demonstrate that genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis. These results highlight a pathway that preserves tissue survival and muscle function in the setting of ischemia. PMID: 28442482 [PubMed - as supplied by publisher]
Source: Circulation - April 25, 2017 Category: Cardiology Authors: McClung JM, McCord TJ, Ryan TE, Schmidt CA, Green TD, Southerland KW, Reinardy JL, Mueller SB, Venkatraman TN, Lascola CD, Keum S, Marchuk DA, Spangenburg EE, Dokun AO, Annex BH, Kontos CD Tags: Circulation Source Type: research

Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Nervous System
Neuronal death after ischemic stroke involves multiple pathophysiological events, as well as a complex molecular mechanism. Inhibiting a single therapeutic target that is involved in several ischemic signaling cascades may be a promising strategy for stroke management. Here, we report the versatile biological roles of tumor necrosis factor receptor–associated factor 3 (TRAF3) in ischemic stroke. Using several genetically manipulated mouse strains, we also demonstrated that TRAF3 inhibition can be neuroprotective. TRAF3 expression, which is robustly induced in response to ischemia/reperfusion (I/R) injury, was detecte...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Gong, J., Li, Z.-Z., Guo, S., Zhang, X.-J., Zhang, P., Zhao, G.-N., Gao, L., Zhang, Y., Zheng, A., Zhang, X.-F., Xiang, M., Li, H. Tags: Apoptosis, Ischemic biology - basic studies, Acute Cerebral Infarction, Oxidant stress Nervous System Source Type: research

SOD1 overexpression prevents acute hyperglycemia-induced cerebral myogenic dysfunction: relevance to contralateral hemisphere and stroke outcomes
In conclusion, our results show that SOD1 overexpression nullified the detrimental effects of HG on myogenic tone and stroke outcomes and that the contralateral hemisphere may be a novel target for the management of acute hyperglycemic stroke.
Source: AJP: Heart and Circulatory Physiology - March 1, 2015 Category: Cardiology Authors: Coucha, M., Li, W., Hafez, S., Abdelsaid, M., Johnson, M. H., Fagan, S. C., Ergul, A. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine Original Articles
Conclusions— Local overexpression of SCF post-MI induces the recruitment of c-kit+ cells at the infarct border area acutely. In the chronic stages, SCF gene transfer was associated with improved cardiac function in a preclinical model of ischemic cardiomyopathy.
Source: Circulation: Heart Failure - January 20, 2015 Category: Cardiology Authors: Ishikawa, K., Fish, K., Aguero, J., Yaniz-Galende, E., Jeong, D., Kho, C., Tilemann, L., Fish, L., Liang, L., Eltoukhy, A. A., Anderson, D. G., Zsebo, K., Costa, K. D., Hajjar, R. J. Tags: Angiogenesis, Myogenesis, Other Treatment, Acute myocardial infarction Original Articles Source Type: research