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Stroke in paediatric pneumococcal meningitis: a cross-sectional population-based study
Before routine infant pneumococcal immunisation and improved access to neuroimaging, around 25% of children with pneumococcal meningitis (PM) suffered ischaemic stroke (IS).1 2 In a population-based retrospective audit (UHS ZAUD2053), we investigated the postimmunisation prevalence of stroke/cerebrovascular disease (CVD), and compared features of children with and without IS/CVD. We included all cases of PM in children <18 years old with a Wessex postcode admitted to our tertiary centre, University Hospital Southampton (UHS) and the eight hospitals in our referral catchment area of Hampshire and Dorset (2001 childh...
Source: Archives of Disease in Childhood - July 11, 2013 Category: Pediatrics Authors: Pryde, K., Walker, W. T., Hollingsworth, C., Haywood, P., Baird, J., Hussey, M., Freeman, A., Gawne-Cain, M., Harms, B., Kirkham, F. J., Faust, S. N. Tags: PostScript Source Type: research

266 A drowsy patient: beyond the familiar territory
A 72-year-old man was brought to the hospital after he was found unresponsive at home by his wife who reported that he has been sleepy in the last few days. He has a background of hypertension, myocardial infarct, and osteoarthritis. His medications include anti-hypertensive and morphine sulphate. On examination, he was drowsy with GCS fluctuating between 9–11 but maintaining his airways. He was moving all four limbs; pupils were small and unequal but reactive to light. Planter reflexes were downgoing. Opioid toxicity was suspected and treated with naloxone without any response. The CT head scan showed no acute patho...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Oo, A., Khine, N. Tags: Poster Presentations Source Type: research

Cortical laminar necrosis due to refractory status epilepticus in a kidney transplant patient with cryptococcal meningitis
Publication date: Available online 17 November 2015 Source:Indian Journal of Transplantation Author(s): Zaheer Virani, Prashant Rajput, Pankaj Agarwal, Rashmi Badhe A 56-year-old diabetic male underwent kidney transplant in 2010. He was brought to the hospital with complaints of vomiting and altered sensorium of 10 days duration. Lumbar puncture revealed cryptococcal meningitis. He was promptly initiated on liposomal amphotericin B and flucytosine. Immunosuppressive agents tacrolimus and mycophenolate mofetil were discontinued. There was an initial improvement in his sensorium but a few days later, he developed super...
Source: Indian Journal of Transplantation - November 17, 2015 Category: Transplant Surgery Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Association of body mass index with COVID-19-related neurologic sequelae: a retrospective cohort study
This study demonstrates the absence of an association between BMI and neurologic manifestations following acute COVID-19 illness. Prospective studies using standardized data collection tools and direct measures of body fat are warranted to obtain more valid effect estimates.
Source: Clinical and Experimental Medicine - December 16, 2022 Category: Research Source Type: research