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Condition: Ischemic Stroke
Education: Study
Procedure: Carotid Endarterectomy

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Total 525 results found since Jan 2013.

Symptomatic Carotid Atherosclerotic Disease: Correlations Between Plaque Composition and Ipsilateral Stroke Risk Clinical Sciences
Conclusions— Features of the vulnerable carotid plaque, including plaque thrombus, low fibrous content, macrophage infiltration, and microvessel density, correlate with predicted stroke risk. This study provides a basis for plaque imaging studies focused on stroke risk stratification.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Howard, D. P. J., van Lammeren, G. W., Rothwell, P. M., Redgrave, J. N., Moll, F. L., de Vries, J.-P. P. M., de Kleijn, D. P. V., den Ruijter, H. M., de Borst, G. J., Pasterkamp, G. Tags: Pathophysiology, Carotid Stenosis, Primary and Secondary Stroke Prevention, Carotid endarterectomy Clinical Sciences Source Type: research

Residual High-Grade Stenosis After Recanalization of Extracranial Carotid Occlusion in Acute Ischemic Stroke Clinical Sciences
Conclusions— A residual high-grade stenosis of the extracranial ICA occurs in 1 of 6 patients with a symptomatic occlusion in the acute stage of cerebral ischemia. Because this may have implications for secondary prevention, we recommend follow-up imaging in these patients within a week after the event. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Luitse, M. J. A., Velthuis, B. K., Dauwan, M., Dankbaar, J. W., Biessels, G. J., Kappelle, L. J., on behalf of the Dutch Acute Stroke Study Group, Majoie, Roos, Duijm, Keizer, van der Lugt, Dippel, Droogh-de Greve, Bienfait, van Walderveen, Wermer, Lyckla Tags: CT and MRI, Acute Cerebral Infarction, Carotid Stenosis Clinical Sciences Source Type: research

Plaque Inflammation and Unstable Morphology Are Associated With Early Stroke Recurrence in Symptomatic Carotid Stenosis Clinical Sciences
Conclusions— Plaque inflammation and other vulnerability features were associated with highest risk of stroke recurrence and may represent therapeutic targets for future stroke prevention trials.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Marnane, M., Prendeville, S., McDonnell, C., Noone, I., Barry, M., Crowe, M., Mulligan, N., Kelly, P. J. Tags: Pathophysiology Clinical Sciences Source Type: research

Early Carotid Revascularization Reduces Readmission for Recurrent Ischemic Stroke in Acute Ischemic Stroke Patients: Analysis of United States Nationwide Readmissions Database (P4.294)
Conclusions:Patients with ischemic stroke undergoing carotid revascularization during the initial hospitalization have significantly lower risk of readmission related to another ischemic strokeDisclosure: Dr. Chaudhry has nothing to disclose. Dr. Gheith has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Afzal has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. Riaz has nothing to disclose. Dr. Sachdeva has nothing to disclose. Dr. Sattar has nothing to disclose. Dr. Razak has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chaudhry, S., Gheith, T., Gu, S., Afzal, M.-R., Rahman, H., Riaz, A., Sachdeva, G., Sattar, A., Razak, A., Qureshi, A. Tags: In-Hospital Stroke Care Source Type: research

Long-Term Outcome After Carotid Artery Stenting: A Population-Based Matched Cohort Study Clinical Sciences
Conclusions— In this nationwide cohort study, CAS was associated with an increased long-term risk of ipsilateral stroke and death during after the perioperative phase when compared with CEA.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Jonsson, M., Lindstrom, D., Gillgren, P., Wanhainen, A., Malmstedt, J. Tags: Cardiovascular Surgery, Cerebrovascular Disease/Stroke, Ischemic Stroke, Stenosis, Vascular Disease Clinical Sciences Source Type: research

CYP2C19 Loss-of-Function Associated with First-Time Ischemic Stroke in Non-surgical Asymptomatic Carotid Artery Stenosis During Clopidogrel Therapy
This study measures effect ofCYP2C19 genotype on ischemic stroke risk during clopidogrel therapy for asymptomatic, extracranial carotid stenosis patients. Using deidentified electronic health records, patients were selected for retrospective cohort using administrative code for carotid stenosis, availability ofCYP2C19 genotype result, clopidogrel exposure, and established patient care. Patients with intracranial atherosclerosis, aneurysm, arteriovenous malformation, prior ischemic stroke, or observation time<1 month were excluded. Dual antiplatelet therapy patients were included. Patients with carotid endarterectomy or ...
Source: Translational Stroke Research - February 21, 2021 Category: Neurology Source Type: research

Short Time Interval Between Neurologic Event and Carotid Surgery Is Not Associated With an Increased Procedural Risk Clinical Sciences
Conclusions—The time interval between the index event and carotid endarterectomy was not associated with the risk of any in-hospital stroke or death in patients with symptomatic carotid stenosis in Germany. In clinically stable patients, carotid endarterectomy might, therefore, be performed safely as soon as possible after the neurological index event.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Tsantilas, P., Kuehnl, A., Konig, T., Breitkreuz, T., Kallmayer, M., Knappich, C., Schmid, S., Storck, M., Zimmermann, A., Eckstein, H.–H. Tags: Complications, Quality and Outcomes, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Reducing Delay of Carotid Endarterectomy in Acute Ischemic Stroke Patients: A Nationwide Initiative Clinical Sciences
Conclusions— Establishing time limits of 4 days to ultrasound examination of the carotids and of 2 weeks to CEA from onset of stroke followed by a systematic multidisciplinary monitoring and auditing of processes was associated with a substantial increase in the proportion of acute ischemic stroke patients who undergo CEA within 2 weeks in Denmark.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Witt, A. H., Johnsen, S. P., Jensen, L. P., Hansen, A. K., Hundborg, H. H., Andersen, G. Tags: Carotid Stenosis, Carotid endarterectomy Clinical Sciences Source Type: research

Recurrent stroke in symptomatic carotid stenosis awaiting revascularization: A pooled analysis
Conclusions: We found high risk of recurrent ipsilateral ischemic events within the 14-day time period currently recommended for CEA. Randomized trials are needed to determine the benefits and safety of urgent vs subacute carotid revascularization within 14 days after symptom onset.
Source: Neurology - February 8, 2016 Category: Neurology Authors: Johansson, E., Cuadrado-Godia, E., Hayden, D., Bjellerup, J., Ois, A., Roquer, J., Wester, P., Kelly, P. J. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Histological Features of Carotid Plaque in Patients With Ocular Ischemia Versus Cerebral Events Clinical Sciences
Conclusions— Carotid plaques from patients undergoing endarterectomy for previous ocular ischemic events have fewer vulnerable plaque features than those from patients with recent cerebral ischemic events, possibly explaining some of the differences in risk of stroke between these groups.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Howard, D. P. J., van Lammeren, G. W., Redgrave, J. N., Moll, F. L., de Vries, J.-P. P. M., de Kleijn, D. P. V., de Borst, G. J., Pasterkamp, G., Rothwell, P. M. Tags: Pathophysiology, Imaging, Carotid Stenosis, Pathology of Stroke, Carotid endarterectomy, Other Vascular biology Clinical Sciences Source Type: research

Prediction of recanalization in acute stroke patients receiving intravenous and endovascular revascularization therapy
ConclusionThe overall likelihood of recanalization was the highest in the endovascular group, and higher for intravenous thrombolysis compared with no revascularization therapy. However, our statistical models of recanalization for each individual patient indicate significant variability between treatment options, suggesting the need to include this prediction in the personalized treatment selection.
Source: International Journal of Stroke - June 30, 2014 Category: Neurology Authors: Guangming Zhu, Patrik Michel, Tudor Jovin, James T. Patrie, Wenjun Xin, Ashraf Eskandari, Weiwei Zhang, Max Wintermark Tags: Research Source Type: research

Registry Report on Kinetics of Rescue Antiplatelet Treatment to Abolish Cerebral Microemboli After Carotid Endarterectomy Brief Reports
Conclusions— These findings suggest that transcranial Doppler-directed tirofiban therapy is more effective than dextran-40 in suppression of cerebral microemboli after carotid endarterectomy.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Saedon, M., Singer, D. R. J., Pang, R., Tiivas, C., Hutchinson, C. E., Imray, C. H. E. Tags: Platelet function inhibitors, Acute Stroke Syndromes, Carotid Stenosis, Doppler ultrasound, Transcranial Doppler etc., Antiplatelets, Carotid endarterectomy, Transient Ischemic Attacks Brief Reports Source Type: research

Sex Differences in Revascularization Interventions after Acute Ischemic Stroke
Conclusions: Over the last decade, women hospitalized for AIS in the United States were less likely than men to receive cerebrovascular and cardiac reperfusion therapies. However, the IV tPA treatment sex disparity may have been eliminated.
Source: Journal of Stroke and Cerebrovascular Diseases - May 8, 2013 Category: Neurology Authors: Amytis Towfighi, Daniela Markovic, Bruce Ovbiagele Tags: Original Articles Source Type: research

Sex Differences in the Presentation, Care, and Outcomes of Transient Ischemic Attack: Results From the Ontario Stroke Registry Brief Reports
Conclusions— We found only minor sex differences in the presentation and management of transient ischemic attack, suggesting that current public awareness campaigns focusing on classic warning signs are appropriate for both women and men. Future work should focus on evaluating whether lower rates of carotid imaging, endarterectomy, and lipid-lowering therapy in women reflect undertreatment of women or are appropriate based on patient eligibility.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Li, O. L., Silver, F. L., Lichtman, J., Fang, J., Stamplecoski, M., Wengle, R. S., Kapral, M. K. Tags: Epidemiology, Secondary Prevention, Compliance/Adherence, Quality and Outcomes Brief Reports Source Type: research

18F-Fluoride and 18F-Fluorodeoxyglucose Positron Emission Tomography After Transient Ischemic Attack or Minor Ischemic Stroke: Case-Control Study Molecular Imaging
Conclusions— 18F-Fluoride PET/CT highlights culprit and phenotypically high-risk carotid plaque. This has the potential to improve risk stratification and selection of patients who may benefit from intervention.
Source: Circulation: Cardiovascular Imaging - March 14, 2017 Category: Radiology Authors: Vesey, A. T., Jenkins, W. S. A., Irkle,, A., Moss, A., Sng,, G., Forsythe, R. O., Clark, T., Roberts, G., Fletcher, A., Lucatelli, C., Rudd, J. H. F., Davenport,, A. P., Mills, N. L., Al-Shahi Salman, R., Dennis, M., Whiteley, W. N., van Beek, E. J. R., D Tags: Translational Studies, Imaging, Nuclear Cardiology and PET, Cerebrovascular Disease/Stroke, Atherosclerosis Molecular Imaging Source Type: research