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Condition: Sleep Disorders
Drug: Melatonin
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Total 986 results found since Jan 2013.
Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice
CONCLUSIONS: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.PMID:37736695 | DOI:10.1111/cns.14436
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xixi Jia Yanan Song Zhengqian Li Ning Yang Taotao Liu Dengyang Han Zhuonan Sun Chengmei Shi Yang Zhou Jie Shi Yajie Liu Xiangyang Guo Source Type: research
Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption
CONCLUSIONS: Our data indicate that melatonin treatment attenuates CRSD-induced cognitive impairment via regulating HDAC3-Bmal1/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.PMID:37721401 | DOI:10.1111/cns.14474
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Yujie Hu Yefan Lv Xiaoyan Long Guoshuai Yang Jinxia Zhou Source Type: research
Melatonin Supplementation for Cancer-Related Fatigue in Patients With Early Stage Breast Cancer Receiving Radiotherapy: A Double-Blind Placebo-Controlled Trial
CONCLUSIONS: In this double-blind placebo-controlled phase III trial, melatonin did not prevent or significantly improve fatigue and other symptoms in patients with early stage breast cancer undergoing RT. The analysis, showing little evidence of an effect, at mid-recruitment, assured early termination of the trial.PMID:37699115 | DOI:10.1093/oncolo/oyad250
Source: The Oncologist - September 12, 2023 Category: Cancer & Oncology Authors: Nitai D Mukhopadhyay Adam Khorasanchi Sudeep Pandey Srinidhi Nemani Gwendolyn Parker Xiaoyan Deng Douglas W Arthur Alfredo Urdaneta Egidio Del Fabbro Source Type: research
Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm consist with a dual oscillator hypothesis
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 11. doi: 10.1152/ajpregu.00095.2023. Online ahead of print.ABSTRACTCircadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of ca. 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch and polysomn...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2023 Category: Physiology Authors: Satoko Hashimoto Takuro Endo Sato Honma Yujiro Yamanaka Ken-Ichi Honma Source Type: research
Ginsenoside Rg5 Improves Sleep by Regulating Energy Metabolism in Sleep-Deprived Rats
Am J Chin Med. 2023 Sep 4:1-20. doi: 10.1142/S0192415X23500817. Online ahead of print.ABSTRACTSleep deprivation (SD) has become a universal social problem. There is a causal relationship between SD and energy metabolism disorder. Phytochemicals have been demonstrated to have excellent sleep-promoting effects, and studies have shown that ginsenoside Rg5 (Rg5) exerts sedative and hypnotic effects. The present study aimed to investigate the role of Rg5 in regulating energy metabolism and explore the potential mechanism of improving sleep. Sleep-deprived rats were randomly divided into a control group (Ctrl), SD model group (S...
Source: The American Journal of Chinese Medicine - September 5, 2023 Category: Complementary Medicine Authors: Jian-Bo Chen Mei-Jia Li Xiao-Hui Huo Tie-Jun Gong Xiao Han Jin-Hui Liu Shuang Liu Yin-Shi Sun Source Type: research
