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Condition: Epilepsy
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Total 35 results found since Jan 2013.
Valproic acid decreases vascular smooth muscle cell proliferation via protein phosphatase 2A-mediated p70 S6 kinase inhibition
In conclusion, our results demonstrate that VPA decreased cell proliferation via PP2A-mediated inhibition of p-p70S6K-Thr389 in basal and PDGF-stimulated VSMCs. The results suggest that VPA could be used in the treatment and prevention of atherosclerosis and in-stent restenosis.PMID:35339758 | DOI:10.1016/j.bbrc.2022.03.100
Source: Atherosclerosis - March 27, 2022 Category: Cardiology Authors: Hansol Lee Yun-Jin Hwang Jung-Hyun Park Du-Hyong Cho Source Type: research
Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF
ConclusionsIn CPxEpic, GAA is metabolized to creatine via GAMT. Biosynthesized creatine is then released into the CSF via MCT12 and supplied to the brain parenchyma.
Source: Fluids and Barriers of the CNS - June 3, 2022 Category: Neuroscience Source Type: research
