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Whole-cell pertussis vaccine in early infancy for the prevention of allergy in children
CONCLUSIONS: There is very low-certainty evidence that a first dose of wP given early in infancy, compared to a first dose of aP, affects the risk of atopic diseases in children. The incidence of all-cause SAEs in wP and aP vaccinees was low, and no cases of encephalopathy were reported. The certainty of the evidence was judged as moderate for all-cause SAEs, and low for encephalopathy. Future studies should use sensitive and specific endpoints of clinical relevance, and should be conducted in settings with high prevalence of IgE-mediated food allergy. Safety endpoints should prioritise common vaccine reactions, parental a...
Source: Cochrane Database of Systematic Reviews - October 25, 2021 Category: General Medicine Authors: Gladymar Perez Chacon Jessica Ramsay Christopher G Brennan-Jones Marie J Estcourt Peter Richmond Patrick Holt Tom Snelling Source Type: research

Successful vaccination with tetanus and diphtheria and acelluar pertussis vaccine after adverse reaction to diphtheria and tetanus toxoids and acellular pertussis vaccine or diphtheria and tetanus vaccine in pediatric patients
Diphtheria, tetanus, and pertussis vaccination is an integral component of the pediatric immunization schedule, with diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine administered to patients as a primary series at 2, 4, and 6 months of age and booster doses at 15 to 18 months and 4 to 6 years of age. A single tetanus and diphtheria and acelluar pertussis (Tdap) vaccine dose is recommended at 11 to 12 years old. Per the Centers for Disease Control and Prevention, contraindications to DTaP and Tdap vaccination include anaphylaxis after a previous dose or to a vaccine component and encephalopathy within 7...
Source: Annals of Allergy, Asthma and Immunology - June 18, 2019 Category: Allergy & Immunology Authors: Neha Sirohi Campbell, Denise Diprimio Kalman Tags: Letter Source Type: research

Successful Vaccination with Tdap after Adverse Reaction to DTaP or DT in Pediatric Patients
Diphtheria, tetanus, and pertussis vaccination is an integral component of the pediatric immunization schedule with DTaP administered to patients as a primary series at 2, 4 and 6 months of age and booster doses at 15 – 18 months and 4-6 years of age. A single Tdap dose is recommended at 11 to 12 years old. Per the CDC, contraindications to DTaP and Tdap vaccination include anaphylaxis after a previous dose or to a vaccine component and encephalopathy within 7 days of administration.1 Anaphylactic reactions to vaccines are rare, occurring at a rate of approximately 1 per one million doses administered.
Source: Annals of Allergy, Asthma and Immunology - June 18, 2019 Category: Allergy & Immunology Authors: Neha S. Campbell, Denise Kalman Source Type: research

Allergic reactions to cow's milk proteins in medications in childhood.
CONCLUSIONS: We suggest caution in administration of pharmaceuticals containing milk allergens in children allergic to milk. PMID: 30830066 [PubMed - in process]
Source: Acta Bio-Medica : Atenei Parmensis - January 28, 2019 Category: General Medicine Authors: Santoro A, Andreozzi L, Ricci G, Mastrorilli C, Caffarelli C Tags: Acta Biomed Source Type: research

The Pertussis Hypothesis: Bordetella pertussis Colonization in the Etiology of Asthma and Diseases of Allergic Sensitization
Decades of peer reviewed evidence demonstrate that: 1)Bordetellapertussisand pertussis toxin are potent adjuvants, inducing asthma and allergic sensitization in animal models of human disease, 2)Bordetella pertussisoften colonizes the human nasopharynx, and is well documented in highly pertussis-vaccinated populations and 3) in children, a history of whooping cough increases the risk of asthma and allergic sensitization disease. We build on these observations with six case studies and offer a pertussis-based explanation for the rapid rise in allergic disease in former East Germany following the fall of the Berlin Wall; the...
Source: Medical Hypotheses - August 9, 2018 Category: Biomedical Science Authors: Keith Rubin, Steven Glazer Source Type: research

A case of anaphylaxis induced by gelatin-contained gel capsule cold medicine.
We report here a 20-year old woman who referred to our clinic for identify the responsible antigen of anaphylaxis. Five days before the reaction, she had a cold and had taken a gel capsule cold medicine, Stona IB Gel®. On the day of the reaction, she took a dose of Stona IB Gel® after eating yogurt. Five minutes after oral administration, she developed a heat sensation and pruritus on her neck, with flushing, abdominal pains, breathing difficulties, and syncope. The specific IgE antibodies measured by ImmunoCAP® were all negative except for gelatin. Prick-prick skin testing revealed positive responses to Stona IB Gel®,...
Source: Allergology International - December 12, 2014 Category: Allergy & Immunology Tags: Arerugi Source Type: research