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Adenovirus-mediated Gene Therapy for Allergy.
Abstract Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of ad...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Ma S, Guan J Tags: Iran J Allergy Asthma Immunol Source Type: research

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy
Peanuts are the most common food to provoke fatal or near-fatal anaphylactic reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral administration.
Source: Journal of Allergy and Clinical Immunology - June 28, 2016 Category: Allergy & Immunology Authors: Odelya E. Pagovich, Bo Wang, Maria J. Chiuchiolo, Stephen M. Kaminsky, Dolan Sondhi, Clarisse L. Jose, Christina C. Price, Sarah F. Brooks, Jason G. Mezey, Ronald G. Crystal Source Type: research