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Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus
CONCLUSION: There is an increasing prevalence of DM in NVIE and it is associated with poorer outcomes. Further studies are crucial to identify the clinical, and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.PMID:33552399 | PMC:PMC7821010 | DOI:10.4330/wjc.v13.i1.11
Source: World Journal of Cardiology - February 8, 2021 Category: Cardiology Authors: Temidayo Abe Harry Onoriode Eyituoyo Gabrielle De Allie Titilope Olanipekun Valery Sammah Effoe Kikelomo Olaosebikan Paul Mather Source Type: research

Neurological Complications in Patients with Infective Endocarditis: Insights from a Tertiary Centre
Conclusions: In this population, embolization to the CNS was common, more often presented as ischemic stroke, and was associated with longer hospitalization, although without significant differences in mortality. In patients with CNS embolization, those submitted to surgery had a good clinical evolution, while patients with septic shock and HIV infection had a worse outcome. These results should be interpreted with caution, taking into consideration that patients with more severe complications or more fragile were probably less often considered for surgery, resulting in selection bias.
Source: Arquivos Brasileiros de Cardiologia - April 16, 2021 Category: Cardiology Source Type: research

Managing Patients with Infectious Endocarditis and Neurological Complication — The Big Dilemma that Persists Until these Days
Conclusions: In this population, embolization to the CNS was common, more often presented as ischemic stroke, and was associated with longer hospitalization, although without significant differences in mortality. In patients with CNS embolization, those submitted to surgery had a good clinical evolution, while patients with septic shock and HIV infection had a worse outcome. These results should be interpreted with caution, taking into consideration that patients with more severe complications or more fragile were probably less often considered for surgery, resulting in selection bias.
Source: Arquivos Brasileiros de Cardiologia - April 16, 2021 Category: Cardiology Source Type: research

Dualistic roles and mechanistic insights of macrophage migration inhibitory factor in brain injury and neurodegenerative diseases
J Cereb Blood Flow Metab. 2022 Nov 11:271678X221138412. doi: 10.1177/0271678X221138412. Online ahead of print.ABSTRACTMacrophage migration inhibitory factor (MIF) is involved in various immune-mediated pathologies and regulates both innate and adaptive immune reactions, thus being related to several acute and chronic inflammatory diseases such as rheumatoid arthritis, septic shock, and atherosclerosis. Its role in acute and chronic brain pathologies, such as stroke and neurodegenerative diseases, has attracted increasing attention in recent years. In response to stimuli like hypoxia, inflammation or infection, different ce...
Source: Atherosclerosis - November 12, 2022 Category: Cardiology Authors: Wei Xuan Wanqing Xie Fengshi Li Dan Huang Ziyu Zhu Yuxuan Lin Binwei Lu Weifeng Yu Yan Li Peiying Li Source Type: research

In-hospital mortality risk factors for patients with cerebral vascular events in infectious endocarditis. A correlative study of clinical, echocardiographic, microbiologic and neuroimaging findings.
CONCLUSIONS: In patients with IE complicated with stroke, the number of lesions observed in neuroimaging examinations and conservative treatment were associated with higher in-hospital mortality. PMID: 26031364 [PubMed - as supplied by publisher]
Source: Archivos de Cardiologia de Mexico - May 29, 2015 Category: Cardiology Authors: González-Melchor L, Kimura-Hayama E, Díaz-Zamudio M, Higuera-Calleja J, Choque C, Soto-Nieto GI Tags: Arch Cardiol Mex Source Type: research

Prosthetic valve endocarditis in patients on hemodialysis
We read with great interest the manuscript entitled “Prognostic factors of infective endocarditis in patients on hemodialysis: A case series from a National Multicenter Registry” by Dr. A. Ramos-Martínez and colleagues showing that hemodialysis patients with IE present a high mortality and that advanced age and complications, such as heart failu re, CNS stroke or septic shock, are associated with mortality [1].
Source: International Journal of Cardiology - December 5, 2017 Category: Cardiology Authors: Jinmiao Chen, Kui Hu, Jun Li, Tao Hong, Chunsheng Wang Tags: Correspondence Source Type: research

Heartfelt sepsis: microvascular injury due to genomic storm.
Abstract Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulnerable patients, with these groups suffering from the highest sepsis mortality. In both groups, many survivors respectively display serious developmental disabilities and cognitive decline. The National Institute of Health National Heart Lung and Blood Institute Panel redefined sepsis as a "severe endothelial dysfunction syndrome in response to intravascular and...
Source: Polish Heart Journal - July 5, 2018 Category: Cardiology Authors: Hawiger J Tags: Kardiol Pol Source Type: research

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