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Total 4363 results found since Jan 2013.

How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research

Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5 & prime;-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection
Molecules, Vol. 28, Pages 6696: Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection Molecules doi: 10.3390/molecules28186696 Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Otávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha João Candido Pilar Mayer João B. Teixeira da Rocha Oscar Endrigo D. Rodrigues Milene Dias Miranda The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits t...
Source: Molecules - September 19, 2023 Category: Chemistry Authors: Amanda Resende Tucci Raquel Mello da Rosa Alice Santos Rosa Ot ávio Augusto Chaves Vivian Neuza Santos Ferreira Thamara Kelcya Fonseca Oliveira Daniel Dias Coutinho Souza Nathalia Roberto Resende Borba Luciano Dornelles Nayra Salazar Rocha Jo ão Candido Tags: Article Source Type: research

Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research

One-step selective layer assemble: A versatile approach for the development of a SARS-CoV-2 electrochemical immunosensor
Anal Chim Acta. 2023 Oct 16;1278:341726. doi: 10.1016/j.aca.2023.341726. Epub 2023 Aug 16.ABSTRACTThe appearance of new viruses and diseases has made the development of rapid and reliable diagnostic tests crucial. In light of it, we proposed a new method for assembling an electrochemical immunosensor, based on a one-step approach for selective layer formation. For this purpose, a mixture containing the immobilizing agent (polyxydroxybutyrate, PHB) and the recognition element (antibodies against SARS-CoV-2 nucleocapsid protein) was prepared and used to modify a screen-printed carbon electrode with electrodeposited graphene ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Gustavo Martins Helena R Galeski Gabrielle A Andrade Marcia G P Valenga Maria K Ramos Aldo J G Zarbin Bruno C Janegitz Marcelo M üller-Santos Emanuel M de Souza Luiz Humberto Marcolino-Junior M árcio F Bergamini Source Type: research

Computational Study on the Mechanisms of Inhibition of SARS-CoV-2 Mpro by Aldehyde Warhead Based on DFT
In this study, a simplified model obtained through truncation... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 13, 2023 Category: Chemistry Authors: Yongsheng Yang Source Type: research