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Vaccination: Veterinary Vaccinations
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Total 1097 results found since Jan 2013.
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research
Preclinical evaluation of a SARS-CoV-2 variant B.1.351-based candidate DNA vaccine
Vaccine. 2023 Sep 17:S0264-410X(23)01091-5. doi: 10.1016/j.vaccine.2023.09.021. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic revealed the critical shortfalls of global vaccine availability for emergent pathogens and the need for exploring additional vaccine platforms with rapid update potential in response to new variants. Thus, it remains essential, for the present evolving SARS-CoV-2/Covid-19 and future pandemics, to continuously develop and characterize new and different vaccine platforms. Here, we describe an expression-optimized DNA vaccine candidate based on the SARS-CoV-2 spike protein of the Beta variant (...
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Ria Lassauni ère Charlotta Polacek Jeanette Linnea Tingstedt Anders Fomsgaard Source Type: research
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research
Preclinical evaluation of a SARS-CoV-2 variant B.1.351-based candidate DNA vaccine
Vaccine. 2023 Sep 17:S0264-410X(23)01091-5. doi: 10.1016/j.vaccine.2023.09.021. Online ahead of print.ABSTRACTThe SARS-CoV-2 pandemic revealed the critical shortfalls of global vaccine availability for emergent pathogens and the need for exploring additional vaccine platforms with rapid update potential in response to new variants. Thus, it remains essential, for the present evolving SARS-CoV-2/Covid-19 and future pandemics, to continuously develop and characterize new and different vaccine platforms. Here, we describe an expression-optimized DNA vaccine candidate based on the SARS-CoV-2 spike protein of the Beta variant (...
Source: Vaccine - September 19, 2023 Category: Allergy & Immunology Authors: Ria Lassauni ère Charlotta Polacek Jeanette Linnea Tingstedt Anders Fomsgaard Source Type: research
Obtaining a high titer of polyclonal antibodies from rats to the SARS-CoV-2 nucleocapsid protein and its N- and C-terminal domains for diagnostic test development
J Immunol Methods. 2023 Sep 11:113558. doi: 10.1016/j.jim.2023.113558. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an enveloped, plus-stranded RNA virus responsible for the Coronavirus Disease 2019 (COVID-19). Patients infected with COVID-19 may be asymptomatic or have symptoms ranging from mild manifestations to severe cases of the disease that could lead to death. The SARS-CoV-2 genome encodes 4 structural proteins, including the Spike protein (S), the Nucleocapsid protein (N), membrane protein (M) and, the envelope (E). The N protein forms a major component of the ribonu...
Source: Journal of Immunological Methods - September 13, 2023 Category: Allergy & Immunology Authors: Michelle Teixeira de Almeida Ana Paula Barbosa Camila Gasque Bomfim Aline Biazola Visnardi Tania Churasacari Vinces Alexandre Ceroni Edison Luiz Durigon Cristiane Rodrigues Guzzo Source Type: research
T cell control of SARS-CoV-2: When, which, and where?
Semin Immunol. 2023 Aug 29;70:101828. doi: 10.1016/j.smim.2023.101828. Online ahead of print.ABSTRACTEfficient immune protection against viruses such as SARS-CoV-2 requires the coordinated activity of innate immunity, B and T cells. Accumulating data point to a critical role for T cells not only in the clearance of established infection, but also for aborting viral replication independently of humoral immunity. Here we review the evidence supporting the contribution of antiviral T cells and consider which of their qualitative features favour efficient control of infection. We highlight how studies of SARS-CoV-2 and other c...
Source: Seminars in Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Mariana O Diniz Mala K Maini Leo Swadling Source Type: research
