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The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway
In this study, we established an in vitro insulin resistance cell model for human HepG2 cells to investigate the possible mechanism of the effect of sitagliptin on glucose metabolism via the SOCS3/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. Since insulin resistance first develops in the liver, palmitic acid was used to generate an insulin resistance cell model in human HepG2 cells, after which small interfering ribonucleic acid (siRNA)-SOCS3 and sitagliptin were used to intervene. We then examined the changes in cell viability and biochemical indices in the insulin resistance cell model. SOCS3, Akt, an...
Source: J Physiol Pharmacol - July 15, 2023 Category: Drugs & Pharmacology Authors: R Ma L Quan Q-Q-G Aleteng L Li J Zhu S Jiang Source Type: research

Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway
Biomed Pharmacother. 2023 Jul 5;165:115113. doi: 10.1016/j.biopha.2023.115113. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases with limited treatment options. Moreover, its prevalence is doubled in type 2 diabetes mellitus (T2DM). Kaempferol (KAP) is a flavonoid compound that has been suggested to have beneficial effects on NAFLD, but studies on the mechanism are lacking, especially in the diabetic state. Herein, we investigated the effect of KAP on NAFLD associated with T2DM and its underlying mechanism in vitro and in vivo. The results of in vitro studies in...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2023 Category: Drugs & Pharmacology Authors: Na Li Lin Yin Jiamin Shang Meidai Liang Zhaoyu Liu Haiguang Yang Guifen Qiang Guanhua Du Xiuying Yang Source Type: research

Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research

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