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Ezrin Is Down-Regulated in Diabetic Kidney Glomeruli and Regulates Actin Reorganization and Glucose Uptake via GLUT1 in Cultured Podocytes.
Abstract Diabetic nephropathy is a complication of diabetes and a major cause of end-stage renal disease. To characterize the early pathophysiological mechanisms leading to glomerular podocyte injury in diabetic nephropathy, we performed quantitative proteomic profiling of glomeruli isolated from rats with streptozotocin-induced diabetes and controls. Fluorescence-based two-dimensional difference gel electrophoresis, coupled with mass spectrometry, identified 29 differentially expressed spots, including actin-binding protein ezrin and its interaction partner, NHERF2, which were down-regulated in the streptozotocin...
Source: The American Journal of Pathology - April 8, 2014 Category: Pathology Authors: Wasik AA, Koskelainen S, Hyvönen ME, Musante L, Lehtonen E, Koskenniemi K, Tienari J, Vaheri A, Kerjaschki D, Szalay C, Révész C, Varmanen P, Nyman TA, Hamar P, Holthöfer H, Lehtonen S Tags: Am J Pathol Source Type: research

High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
Abstract The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubules and up-regulated in the diabetic state. Previously, we reported its transcriptional and translation regulation by high glucose (HG), osmolytes, and fatty acids. However, its epigenetic regulation is unknown. Bisulfite sequencing revealed that both human and mouse MIOX promoters, enriched with CpG sites, are hypomethylated and unmethylated under HG ambience and hyperglycemic states associated with increased MIOX expression. Eletrophoretic mobility shift assays revealed increased binding of unmethylated oligos with nucleopro...
Source: The American Journal of Pathology - February 12, 2017 Category: Pathology Authors: Sharma I, Dutta RK, Singh NK, Kanwar YS Tags: Am J Pathol Source Type: research

Adiponectin exerts antiproliferative effect on human placenta via modulation of the JNK/c-Jun pathway.
In conclusion, adiponectin inhibits HG-induced proliferation of BeWo cells through down-regulation of JNK/c-jun phosphorylation. PMID: 25031708 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Chen H, Chen H, Wu Y, Liu B, Li Z, Wang Z Tags: Int J Clin Exp Pathol Source Type: research

Plasmalemma Vesicle-Associated Protein Has a Key Role in Blood-Retinal Barrier Loss.
In conclusion, PLVAP is an essential cofactor in VEGF-induced BRB permeability and may become an interesting novel target for diabetic macular edema therapy. PMID: 26878208 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - February 12, 2016 Category: Pathology Authors: Wisniewska-Kruk J, van der Wijk AE, van Veen HA, Gorgels TG, Vogels IM, Versteeg D, Van Noorden CJ, Schlingemann RO, Klaassen I Tags: Am J Pathol Source Type: research

1,25(OH)2D3 provides protection against diabetic kidney disease by downregulating the TLR4-MyD88-NF- κB pathway.
In conclusion, high doses of 1,25(OH)2D3 protected against tubulointerstitial fibrosis both in vitro and in vivo by downregulating the expression of TLR4-MyD88-NF-κB. PMID: 32240615 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - March 29, 2020 Category: Pathology Authors: Liu P, Li F, Xu X, Li S, Dong X, Chen L, Bai B, Wang Y, Qiu M, Dong Y Tags: Exp Mol Pathol Source Type: research

Photoreceptor cell calcium dysregulation and calpain activation promote pathogenic photoreceptor oxidative stress and inflammation in prodromal diabetic retinopathy
In this study, we test the hypothesis that diabetes promotes a greater than normal cytosolic calcium level in rod cells that activates a Ca2+-sensitive protease, calpain, resulting in oxidative stress and inflammation, two pathogenic factors of early diabetic retinopathy (DR). Nondiabetic and 2-months diabetic C57Bl/6J and calpain1 knockout (Capn1-/-) mice were studied; subgroups were treated with a calpain inhibitor (CI). Ca2+ content was measured in photoreceptors using Fura-2. Retinal calpain expression was studied by qTR-PCR and immunohistochemistry. Superoxide and expression of inflammatory proteins were measured usin...
Source: The American Journal of Pathology - July 2, 2021 Category: Pathology Authors: Aicha Saadane Yunpeng Du Wallace B Thoreson Masaru Miyagi Emma M Lessieur Jianying Kiser Xiangyi Wen Bruce A Berkowitz Timothy S Kern Source Type: research

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