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Dupilumab strengthens HSV-1 specific immune responses in atopic dermatitis
CONCLUSION: Our findings suggest that dupilumab may improve the HSV-1-specific immune response in AD due to an increased type I immune response and a reduction of HSV-1-specific IgE.PMID:37660986 | DOI:10.1016/j.jaci.2023.08.024
Source: Herpes - September 3, 2023 Category: Infectious Diseases Authors: Stephan Traidl Leonard Harries Petra Kienlin Gabriele Begemann Lennart M Roesner Thomas Werfel Source Type: research

Phenotypic and Endotypic Determinants of Atopic Dermatitis Severity from the ADRN Registry
CONCLUSION: In a diverse US AD population, severity was associated with a history of atopic disorders, skin and extracutaneous bacterial and viral infections (by history and physical examination), higher IgE, eosinophilia and allergen sensitization, atopic skin manifestations (i.e., excoriation, hyperlinear palms and ichthyosis), and atopic ocular features (i.e., blepharitis, conjunctivitis, and ectropion) as well as asthma findings (i.e., wheezing). Data from our prospective registry significantly advances our understanding of AD phenotypes and endotypes, which is critical to achieve optimal management.PMID:37182563 | DOI...
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Eric L Simpson Anna De Benedetto Mark Boguniewicz Peck Y Ong Stephanie Lussier Miguel Villarreal Lynda C Schneider Amy S Paller Emma Guttman-Yassky Jon M Hanifin Jonathan M Spergel Kathleen C Barnes Gloria David Briahnna Austin Donald Y M Leung Lisa A Bec Source Type: research

Current status of mites and mite-borne diseases in India
J Vector Borne Dis. 2023 Jan-Mar;60(1):1-10. doi: 10.4103/0972-9062.361175.ABSTRACTMites act as the vectors of zoonotic vector-borne disease scrub typhus caused by the rickettsial pathogen Orientia tsutsugamushi. In India, scrub typhus is transmitted by the mite Leptotrombidium deliense. Rodents are the reservoirs and support the spread of this disease. Sarcoptes scabiei or the itch mite is causing scabies which is a common skin infection in India. Dermatitis, trombiculosis, and mite dust allergy are common mite-borne diseases transmitted by Pyemotidae family. D. brevis folliculorum and Demodex brevis are two major mite sp...
Source: Journal of Vector Borne Diseases - April 7, 2023 Category: Infectious Diseases Authors: R Govindarajan V Rajamannar Ashwani Kumar Philip P Samuel Source Type: research

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