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Total 8248 results found since Jan 2013.

Risk Factors Associated with Peanut Allergy in a High Risk Infant Cohort (CoFAR)
To determine baseline demographic, clinical and serum/skin test parameters associated with development of peanut allergy (PNA) in a cohort of 3-15 month olds with likely egg/milk allergy and/or moderate-severe atopic dermatitis and a positive egg/milk skin prick test (SPT), but no known PNA.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Scott H. Sicherer, Robert A. Wood, Tamara T. Perry, Stacie M. Jones, Donald Y.M. Leung, Alice Henning, Peter Dawson, A. Wesley Burks, Robert W. Lindblad, Hugh A. Sampson Source Type: research

Impact of food allergy on the growth of children with moderate-severe atopic dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10% to 20% of children in the United States, with 1 of 3 of those affected having moderate to severe disease.1 Significant sleep disturbance due to itching and increased metabolic demands due to rapid skin turnover and chronic inflammation are hypothesized to impact the growth of children with AD.2,3 Between 15% and 40% of children with AD have food allergy (FA) as well, which alone can have adverse growth consequences.4,5 However, few studies to date have examined the role that coexistent food allergy has on the growth of children with AD.
Source: Journal of Allergy and Clinical Immunology - February 4, 2018 Category: Allergy & Immunology Authors: Rekha D. Jhamnani, Samara Levin, Marjohn Rasooly, Kelly D. Stone, Joshua D. Milner, Celeste Nelson, Tom DiMaggio, Nina Jones, Anthony L. Guerrerio, Pamela A. Frischmeyer-Guerrerio Tags: Letter to the Editor Source Type: research

Very early introduction of semisolid foods in preterm infants does not increase food allergies or atopic dermatitis.
CONCLUSION: The very early introduction of complementary foods into the diet of preterm babies did not increase the incidence of food allergies or atopic dermatitis even among the most preterm infants. This finding supports the hypothesis that the gut-associated lymphoid tissue of preterm infants is ready to encounter food proteins and to begin the maturation process within 3-6 months of birth, regardless of the gestational age. PMID: 29981439 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - July 4, 2018 Category: Allergy & Immunology Authors: Yrjänä JM, Koski T, Törölä H, Valkama M, Kulmala P Tags: Ann Allergy Asthma Immunol Source Type: research

Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children.
CONCLUSIONS: BHR to Provocholine (PC20 < 8 mg/mL) was observed in 17.2% of 7-year-olds children from the general population and the cutoff value of PC20 for the diagnosis of current asthma was 5.8 mg/mL in this age group. The risk factors for BHR and current asthma showed discrepancies suggesting different underlying mechanisms. Bronchial provocation testing with Provocholine will be a useful clinical tool in the future. PMID: 30088367 [PubMed]
Source: Allergy, Asthma and Immunology Research - August 10, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects.
Authors: Sharma G, Im SH Abstract The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc., dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those...
Source: Allergy, Asthma and Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Report from the National Institute of Allergy and Infectious Diseases Workshop on “Atopic Dermatitis and the Atopic March: Mechanisms and Interventions”
Atopic dermatitis (AD) affects up to 20% of children world-wide and is an increasing public health problem particularly in developed countries. Although AD in infants and young children can resolve, there is a well-recognized, increased risk of sequential progression from AD to other atopic diseases including food allergy, allergic rhinitis, allergic asthma and allergic rhinoconjunctivitis; a process referred to as the “atopic march”. The mechanisms underlying the development of AD and subsequent progression to other atopic comorbidities, particularly food allergy, are incompletely understood and the subject of intense investigation.
Source: Journal of Allergy and Clinical Immunology - January 9, 2019 Category: Allergy & Immunology Authors: Wendy F. Davidson, Donald Y.M. Leung, Lisa A. Beck, Cecilia M. Berin, Mark Boguniewicz, William W. Busse, Talal A. Chatila, Raif S. Geha, James E. Gern, Emma Guttman-Yassky, Alan D. Irvine, Brian S. Kim, Heidi H. Kong, Gideon Lack, Kari C. Nadeau, Julie S Source Type: research

IgE Testing Can Predict Food Allergy Status in Patients with Moderate-Severe Atopic Dermatitis
Atopic dermatitis (AD) is the most common chronic inflammatory disease of the skin in pediatric populations, affecting up to 20% of children in industrialized countries.1-4 AD is frequently associated with other atopic diseases.5, 6 Up to two-thirds of AD patients are sensitized to food antigens, and 15-40% have clinical food allergy.7-11 Children with severe and persistent AD are at highest risk for having coexistent food allergy.5, 12, 13
Source: Annals of Allergy, Asthma and Immunology - January 9, 2019 Category: Allergy & Immunology Authors: Pamela A. Frischmeyer-Guerrerio, Marjohn Rasooly, Wenjuan Gu, Samara Levin, Rekha D. Jhamnani, Joshua D. Milner, Kelly Stone, Anthony L. Guerrerio, Joseph Jones, Magnus P. Borres, Erica Brittain Source Type: research

Early life atopic dermatitis increases food allergy risk throughout childhood
Food allergy (FA) is often co-expressed with atopic dermatitis (AD), particularly early in life. However, how early life atopic dermatitis affects food allergy risk and phenotype are not well described.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Anne Marie Singh, Christopher J. Tisler, Lisa Salazar, Susan Doyle, Michael D. Evans, Victoria Rajamanickam, Ronald E. Gangnon, James E. Gern, Daniel J. Jackson, Robert F. Lemanske Source Type: research

Presentation and natural history of progestogen hypersensitivity.
CONCLUSION: Although the medical literature on progestogen hypersensitivity is limited to case reports and small case series, significant heterogeneity exists in clinical presentation among patients. PMID: 30712576 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Foer D, Buchheit KM Tags: Ann Allergy Asthma Immunol Source Type: research

Occupational asthma, rhinitis, contact dermatitis and severe milk allergy caused by primary occupational exposure to casein
Respiratory allergy to milk proteins, including casein, remains rare in adults and there are only few case reports in the context of occupational allergy (1, 2). Moreover, casein is not listed as a substance that can cause occupational asthma (3).
Source: Annals of Allergy, Asthma and Immunology - April 25, 2019 Category: Allergy & Immunology Authors: Alla Nakonechna, David Matthews, Ravishankar Sargur Tags: Letters Source Type: research

Occupational asthma, rhinitis, contact dermatitis, and severe milk allergy caused by primary occupational exposure to casein
Respiratory allergy to milk proteins, including casein, remains rare in adults, and only a few case reports have been made in the context of occupational allergy.1,2 Moreover, casein is not listed as a substance that can cause occupational asthma.3
Source: Annals of Allergy, Asthma and Immunology - April 25, 2019 Category: Allergy & Immunology Authors: Alla Nakonechna, David Matthews, Ravishankar Sargur Tags: Letter Source Type: research

Interactions Between Atopic Dermatitis and Staphylococcus aureus Infection: Clinical Implications.
Authors: Kim J, Kim BE, Ahn K, Leung DYM Abstract Staphylococcus aureus commonly colonizes the skin of atopic dermatitis (AD) patients and contributes to the development and exacerbation of AD. Multiple factors are associated with colonization of AD skin by S. aureus, including the strength of S. aureus-corneocyte adhesion, deficiency of antimicrobial peptides, decreased levels of filaggrin and filaggrin degradation products, overexpressed Th2/Th17 cytokines, microbial dysbiosis and altered lipid profiles. S. aureus colonization on AD skin causes skin barrier dysfunction through virulence factors such as superantig...
Source: Allergy, Asthma and Immunology Research - July 25, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Safety of Ultra-rush Schedule of Subcutaneous Allergen Immunotherapy With House Dust Mite Extract Conducted in an Outpatient Clinic in Patients With Atopic Dermatitis and Allergic Rhinitis.
CONCLUSIONS: UR-SCIT with tyrosine-adsorbed HDM extract conducted in an outpatient clinic was tolerable in patients with AD and AR. UR-SCIT can be a useful method to start a SCIT in patients with AD and AR. PMID: 31552719 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

From the Pages of Allergy Watch: January 2020
For this ‘From the Pages of Allergy Watch’ reviews from several recent issues were selected which review articles about Allergic Skin Diseases, the focus of this issue of the Annals. The first article describes a unique minimally invasive method of skin tape stripping to identify infants with atopic derm atitis who are at increased risk for food allergy. The next study investigates the difference between IgE sensitivity and clinical reactivity to foods in children with atopic dermatitis. The last investigates the impact of UV light exposure and the development of atopic dermatitis in infancy.
Source: Annals of Allergy, Asthma and Immunology - October 14, 2019 Category: Allergy & Immunology Authors: Gerald B. Lee, Vivian Hernandez-Trujillo, Stanley M. Fineman Source Type: research

A300 elevated allergic comorbidity in patients with food protein-induced enterocolitis
Despite being classified as an allergy, the epidemiologic relationships between food protein-induced enterocolitis syndrome (FPIES) and other allergic manifestations (atopic dermatitis, AD; IgE-mediated food allergy, IgE-FA; asthma; allergic rhinitis, AR) are not well understood.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: M. Ruffner, K. Wang, J. Dudley, A. Cianferoni, R. Grundmeier, J. Spergel, T. Brown-Whitehorn, D. Hill Tags: Food Allergy Source Type: research