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Potential biomarkers with plasma cortisol, brain-derived neurotrophic factor and nitrites in patients with acute ischemic stroke.
CONCLUSION: Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage. PMID: 28982330 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - October 5, 2017 Category: Neurology Authors: Casas S, Perez AF, Mattiazzi M, Lopez J, Folgueira A, Gargiulo-Monachelli GM, Deniselle MCG, De Nicola AF Tags: Curr Neurovasc Res Source Type: research

Hypercoagulability and Migraine
BackgroundA growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro‐emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AimOur objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated es...
Source: Headache: The Journal of Head and Face Pain - February 8, 2017 Category: Neurology Authors: Gretchen E. Tietjen, Stuart A. Collins Tags: Headache Currents Source Type: research

Hypercoagulability and Migraine.
Abstract BACKGROUND: A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke. AIM: Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including tho...
Source: Headache - February 8, 2017 Category: Neurology Authors: Tietjen GE, Collins SA Tags: Headache Source Type: research

Sex differences in cell genesis, hippocampal volume and behavioral outcomes in a rat model of neonatal HI.
Abstract Hypoxia-ischemia (HI) of the brain in near-term and term infants is a leading cause of infant mortality and lifelong disability but current therapeutic approaches remain limited. Males consistently display greater vulnerability to the deleterious consequences of HI in both humans and animal models. Neurogenesis increases after neonatal HI and offers a potential therapeutic target for recovery. The steroid hormone estradiol has been extensively explored as a neuroprotectant in adult models of stroke but with mixed results. Less consideration has been afforded to this naturally occurring agent in the develo...
Source: Experimental Neurology - September 12, 2015 Category: Neurology Authors: Waddell J, Hanscom M, Shalon Edwards N, McKenna MC, McCarthy MM Tags: Exp Neurol Source Type: research