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Evaluation of the Therapeutic Effect of Curcumin-Conjugated Zinc Oxide Nanoparticles on Reserpine-Induced Depression in Wistar Rats
In conclusion, curcumin-conjugated zinc oxide nanoparticles demonstrate potent antidepressant effects, alleviating depressive-like behavior in rats. These findings support Zn(cur)O NPs as a promising therapeutic strategy for depression management, warranting further investigation and clinical validation.PMID:37713054 | DOI:10.1007/s12011-023-03849-z
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Heba M Fahmy Fatmaalzahraa A Aboalasaad Ayman S Mohamed Fathi A Elhusseiny Yasser A Khadrawy Ahmed Elmekawy Source Type: research

Oxidative stress responses and their alterations in the Nrf2-NMDA receptor pathway in the brain of suicide victims
This study aimed to investigate the relationship between oxidative stress progression, Nrf2 regulation, and N-methyl-D-aspartate receptor (NMDA) subunit composition in the hippocampus (Hp) and frontal cortex (FCx) of suicide victims (n=14) and matched controls (n=8). Furthermore, zinc and magnesium concentrations and their potency to inhibit [3H] MK-801 (radioactively labeled form of MK-801 - dizocilpine, a well-characterized NMDAR channel uncompetitive antagonist frequently used in receptor-binding assays) binding to NMDA receptor channels were measured. Our results revealed a statistically significant increase in protein...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: P Panczyszyn-Trzewik P Misztak W Opoka G Nowak M Sowa-Kucma Source Type: research

Bee venom (Apis mellifera L.) rescues zinc oxide nanoparticles induced neurobehavioral and neurotoxic impact via controlling neurofilament and GAP-43 in rat brain
This study investigated the possible beneficial role of the bee venom (BV, Apis mellifera L.) against zinc oxide nanoparticles (ZNPs)-induced neurobehavioral and neurotoxic impacts in rats. Fifty male Sprague Dawley rats were alienated into five groups. Three groups were intraperitoneally injected distilled water (C 28D group), ZNPs (100 mg/kg b.wt) (ZNPs group), or ZNPs (100 mg/kg.wt) and BV (1 mg/ kg.bwt) (ZNPs + BV group) for 28 days. One group was intraperitoneally injected with 1 mL of distilled water for 56 days (C 56D group). The last group was intraperitoneally injected with ZNPs for 28 days, then BV for another 28...
Source: Environmental Science and Pollution Research International - July 13, 2023 Category: Environmental Health Authors: Naglaa Z H Eleiwa Mahmoud Abo-Alkasem Ali Enas N Said Mohamed M M Metwally Yasmina M Abd-ElHakim Source Type: research

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