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Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved. Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

In silico design, production and immunization evaluation of a recombinant bivalent fusion protein candidate vaccine against E. coli O157:H7
Int Immunopharmacol. 2022 Nov 27;114:109464. doi: 10.1016/j.intimp.2022.109464. Online ahead of print.ABSTRACTIn silico techniques are highly suited for both the discovery of new and development of available vaccines. Escherichia coli O157: H7, a main cause of food poisoning can infect humans through the consumption of contaminated water or food. Vaccination is a choice strategy to combat the bacterium. In the present study, we designed, expressed and purified a chimeric protein comprising two antigens of Escherichia coli O157: H7, including intimin and flagellin proteins, as a vaccine candidate and evaluated its immunizat...
Source: International Immunopharmacology - November 30, 2022 Category: Allergy & Immunology Authors: Hossein Samiei Shahram Nazarian Abass Hajizade Emad Kordbacheh Source Type: research

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

About the need to address pediatric health inequalities in French Guiana : a scoping review
CONCLUSION: Children living in French Guiana have worse pediatric health indicators in comparison with children from mainland France.PMID:35644716 | DOI:10.1016/j.arcped.2022.03.009
Source: Archives de Pediatrie - June 1, 2022 Category: Pediatrics Authors: L Osei C Basurko M Nacher N Vignier N Elenga Source Type: research

Review Norovirus
Uirusu. 2020;70(2):117-128. doi: 10.2222/jsv.70.117.ABSTRACTNoroviruses commonly cause infectious gastroenteritis and massive food poisoning. There is an urgent need to elucidate the infection mechanism of noroviruses and to develop vaccines and therapeutic drugs. In addition to human disease, noroviruses have been implicated in animal disease. Noroviruses that cause murine diseases can be propagated in strained cultured cells, and for many years, murine norovirus has been used as a model for human noroviruses that could not be propagated in cultured cells. That model and advances in technology have been instrumental in ba...
Source: Uirusu. Journal of Virology - September 21, 2021 Category: Virology Authors: Kazuhiko Katayama Source Type: research

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