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Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
CONCLUSIONS: We found that nebulised antibiotics, alone or with oral antibiotics, were better than no treatment for early infection with P aeruginosa. Eradication may be sustained in the short term. There is insufficient evidence to determine whether these antibiotic strategies decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials comparing two active treatments have failed to show differences in rates of eradication of P aeruginosa. One large trial showed that intravenous ceftazidime with tobramycin is not superior to oral ci...
Source: Cochrane Database of Systematic Reviews - June 2, 2023 Category: General Medicine Authors: Simon C Langton Hewer Sherie Smith Nicola J Rowbotham Alexander Yule Alan R Smyth Source Type: research

An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of < em > P. aeruginosa < /em >
In conclusion, an rRNA fragment secreted by AEC in EVs that targets the fluoroquinolone efflux pump MexHI-OpmD down-regulated these proteins and increased the ciprofloxacin sensitivity of P. aeruginosa. A combination of rRNA fragments and ciprofloxacin packaged in nanoparticles or EVs may benefit patients with antibiotic-resistant P. aeruginosa infections.PMID:37256658 | DOI:10.1152/ajplung.00150.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 31, 2023 Category: Cytology Authors: Katja Koeppen Thomas H Hampton Roxanna Barnaby Carolyn Roche Scott A Gerber Young Ah Goo Byoung-Kyu Cho Danielle M Vermilyea Deborah A Hogan Bruce A Stanton Source Type: research

Impact of N-Acetylcysteine and Antibiotics Against Single and Dual Species Biofilms of Pseudomonas aeruginosa and Achromobacter xylosoxidans
Curr Microbiol. 2022 Nov 25;80(1):5. doi: 10.1007/s00284-022-03122-x.ABSTRACTLungs of cystic fibrosis patients are often colonized or infected with organisms, such as Pseudomonas aeruginosa and other emerging pathogenic bacteria such as Achromobacter xylosoxidans. Further, it is well established that infections of the cystic fibrosis lung airways are caused by polymicrobial infections, although its composition and diversity may change throughout the patient's life. In the present study, we investigated the effects of N-acetylcysteine (NAC) and amikacin, aztreonam, ciprofloxacin, and tobramycin alone and in combination agai...
Source: Current Microbiology - November 26, 2022 Category: Microbiology Authors: Fatima Nur Yilmaz Mayram Hacioglu Ebru Haciosmanoglu Aldogan Source Type: research

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