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Effectiveness of 13-valent pneumococcal conjugate vaccine on all-cause pneumonia in children under 5  years in Shanghai, China: An observational study
CONCLUSIONS: PCV13 vaccination among children aged 0-5 years substantially reduced the incidence of all-cause pneumonia. Direct immunization of children under 5 years is an effective strategy to combat outpatient pneumonia, and hospitalized pneumonia.PMID:37620204 | DOI:10.1016/j.vaccine.2023.08.041
Source: Vaccine - August 24, 2023 Category: Allergy & Immunology Authors: Jie Tian Bo Zheng Laibao Yang Ying Guan Chunze Xu Weibing Wang Source Type: research

20 ‑Valent Pneumococcal Conjugate Vaccine: Pediatric First Approval
This article summarizes the milestones in the development of PCV20 leading to this first pediatric approval for active immunization for the prevention of IPD and otitis media caused by S. pneumoniae.PMID:37440125 | DOI:10.1007/s40272-023-00584-9
Source: Paediatric Drugs - July 13, 2023 Category: Pediatrics Authors: Matt Shirley Source Type: research

Non-protective immunity after standard pneumococcal vaccination series identified as a potential contributing risk factor for refractory otolaryngologic conditions in children
CONCLUSION: In pediatric patients with recurrent infectious otolaryngologic disease refractory to traditional medical and surgical therapy, inadequate responses to pneumococcal vaccination may be revealed. This correlation represents a potential pathway for diagnosis and therapy.PMID:37386844 | DOI:10.1177/00034894231182745
Source: The Annals of Otology, Rhinology, and Laryngology - June 30, 2023 Category: ENT & OMF Authors: Caroline A Bonaventure Adele K Evans Source Type: research

A novel immuno-molecular strategy for the detection of Streptococcus pneumoniae serotypes in human cerebrospinal and middle ear fluids
J Immunol Methods. 2023 Jun 20:113516. doi: 10.1016/j.jim.2023.113516. Online ahead of print.ABSTRACTStreptococcus pneumoniae is one of the most common microorganisms causing acute otitis media (AOM) in children. While bacterial culture of middle ear fluid (MEF) is the gold standard to detect the etiological organisms, several host and pathogen factors impact the survival of the organisms resulting in false negatives. To overcome this limitation, we have developed and validated an innovative multiplex immuno-molecular assay to screen and detect the S. pneumoniae 15-valent pneumococcal conjugate vaccine (PCV15; STs 1, 3, 4,...
Source: Journal of Immunological Methods - June 22, 2023 Category: Allergy & Immunology Authors: Gowrisankar Rajam Kate L Hicks Joseph M Antonello Yuhua Zhang Sarah Irey Julia Kelly Stephanie Cooper Leonard J Rubinstein Source Type: research

A retrospective cohort study investigating the comparative effectiveness of pneumococcal vaccines against hospitalisation with otitis media and pneumonia in New Zealand
CONCLUSION: These results should offer reassurance about the equivalence of these pneumococcal vaccines against the broader pneumococcal disease outcomes OM and pneumonia.PMID:37244807 | DOI:10.1016/j.vaccine.2023.05.040
Source: Vaccine - May 27, 2023 Category: Allergy & Immunology Authors: Janine Paynter Anna S Howe Emma Best Helen Petousis-Harris Source Type: research

Immune responses and protection against Streptococcus pneumoniae elicited by recombinant Bordetella pertussis adenylate cyclase (CyaA) carrying fragments of pneumococcal surface protein A, PspA
Vaccine. 2023 May 24:S0264-410X(23)00570-4. doi: 10.1016/j.vaccine.2023.05.031. Online ahead of print.ABSTRACTStreptococcus pneumoniae is a common agent of important human diseases such as otitis media, pneumonia, meningitis and sepsis. Current available vaccines that target capsular polysaccharides induce protection against invasive disease and nasopharyngeal colonization in children, yet their efficacy is limited to the serotypes included in the formulations. The virulence factor Pneumococcal Surface Protein A (PspA) interacts with host immune system and helps the bacteria to evade phagocytosis. Due to its essential role...
Source: Vaccine - May 26, 2023 Category: Allergy & Immunology Authors: Giovanna Brito Carneiro Julia Tavares Castro Marilyne Davi Eliane Namie Miyaji Daniel Ladant Maria Leonor Sarno Oliveira Source Type: research

Streptococcus pneumoniae as cause of acute otitis media (AOM) in Slovak children in the pneumococcal conjugate vaccine era (2008-2019)
Vaccine. 2022 Dec 2:S0264-410X(22)01423-2. doi: 10.1016/j.vaccine.2022.11.025. Online ahead of print.NO ABSTRACTPMID:36470684 | DOI:10.1016/j.vaccine.2022.11.025
Source: Vaccine - December 5, 2022 Category: Allergy & Immunology Authors: Matus Macaj Lubica Perdochova Janka Jakubikova Source Type: research

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