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Specialty: Lipidology
Condition: Cholesterol

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Total 29 results found since Jan 2013.

Lipid management in people with peripheral artery disease
Purpose of review To summarize recent data on the role of dyslipidaemia and the benefit from managing this in people with disease of the abdominal aorta and its peripheral branches (peripheral artery disease, PAD). Recent findings Findings from the Further Cardiovascular Outcomes Research with Proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibition in Subjects with Elevated Risk (FOURIER) trial demonstrate the benefit of intensely lowering low-density lipoprotein-cholesterol (LDL-c) in people with PAD to substantially reduce the incidence of major cardiovascular events (MACE; myocardial infarction, stroke or ...
Source: Current Opinion in Lipidology - November 5, 2019 Category: Lipidology Tags: THERAPY AND CLINICAL TRIALS: Edited by Erik S.G. Stroes and Gerald F. Watts Source Type: research

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults Patient-Oriented and Epidemiological Research
The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain. We determined the association of PCSK9 LOFVs with Lp(a) measures among black adults. Genotyping for PCSK9 LOFVs was conducted in 10,196 black Reasons for Geographic and Racial Differences in Stroke study participants. Among 241 participants with and 723 randomly selected participants without PCSK9 LOFVs, Lp(a) concentations, apo(a) kringle IV (KIV) repeats (a proxy for isoform size), and oxidized pho...
Source: The Journal of Lipid Research - October 31, 2019 Category: Lipidology Authors: Mefford, M. T., Marcovina, S. M., Bittner, V., Cushman, M., Brown, T. M., Farkouh, M. E., Tsimikas, S., Monda, K. L., Lopez, J. A. G., Muntner, P., Rosenson, R. S. Tags: Patient-Oriented and Epidemiological Research Source Type: research

Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged measure of inflammation and oxidative stress and has been used to predict multiple cardiovascular abnormalities, but data rela...
Source: Lipids in Health and Disease - May 30, 2019 Category: Lipidology Authors: Hao-Yu Wang, Wen-Rui Shi, Xin Yi, Ya-Ping Zhou, Zhi-Qin Wang and Ying-Xian Sun Tags: Research Source Type: research

PCSK9 inhibition in patients with and without prior myocardial infarction or ischemic stroke: A pooled analysis of nine randomized-controlled studies of alirocumab
Patients with prior cardiovascular events are at very high risk of recurrent events and may benefit from low-density lipoprotein cholesterol (LDL-C) lowering beyond that achieved with maximally tolerated statins.
Source: Journal of Clinical Lipidology - April 8, 2019 Category: Lipidology Authors: Eric Bruckert, Dean J. Kereiakes, Michael J. Koren, Michael J. Louie, Alexia Letierce, Kathryn Miller, Christopher P. Cannon Source Type: research

The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi ’an, China
Serum lipids [total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)] are risk factors for stroke, but the relationships between...
Source: Lipids in Health and Disease - January 5, 2019 Category: Lipidology Authors: Beiyu Zhao, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Yu Jiang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang and Qiumin Qu Tags: Research Source Type: research

Low LDL-C and risk of hemorrhagic stroke in Chinese adults
It is well-established that higher LDL and total cholesterol are associated with increased risk of atherosclerotic cardiovascular disease (ASCVD), that is, coronary heart disease (CHD) and ischemic stroke events, and that cholesterol-lowering by statins and other therapies reduce ASCVD risk. However, the picture is less clear for the 10% to 20% of strokes that are hemorrhagic rather than ischemic. A meta-analysis of observational studies shows that lower levels of LDL-C and total cholesterol are associated with higher risk of hemorrhagic strokes (HS), and with intracranial hemorrhage (ICH), a subset of HS.
Source: Journal of Clinical Lipidology - September 1, 2018 Category: Lipidology Authors: Rachel H. Mackey Tags: Editorial Source Type: research

Twenty-year epidemiologic study on LDL-C levels in relation to the risks of atherosclerotic event, hemorrhagic stroke, and cancer death among young and middle-aged population in China
Lowering elevated low-density lipoprotein cholesterol (LDL-C) levels is a key strategy in primary prevention of atherosclerotic cardiovascular disease (ASCVD), but the optimal LDL-C level is not well established in Chinese.
Source: Journal of Clinical Lipidology - June 26, 2018 Category: Lipidology Authors: Xingguang Zhang, Jing Liu, Miao Wang, Yue Qi, Jiayi Sun, Jun Liu, Ying Wang, Yongchen Hao, Yan Li, Mengge Zhou, Dong Zhao Tags: Original Article Source Type: research

Twenty-year epidemiologic study on LDL cholesterol levels in relation to the risks of atherosclerotic event, hemorrhagic stroke, and cancer death among young and middle-aged population in China
Lowering elevated low-density lipoprotein cholesterol (LDL-C) level is a key strategy in primary prevention of atherosclerotic cardiovascular disease (ASCVD), but the optimal LDL-C level is not well established in Chinese.
Source: Journal of Clinical Lipidology - June 26, 2018 Category: Lipidology Authors: Xingguang Zhang, Jing Liu, Miao Wang, Yue Qi, Jiayi Sun, Jun Liu, Ying Wang, Yongchen Hao, Yan Li, Mengge Zhou, Dong Zhao Tags: Original Research Source Type: research

Association of peripheral differential leukocyte counts with dyslipidemia risk in Chinese patients with hypertension: insight from the China Stroke Primary Prevention Trial Patient-Oriented and Epidemiological Research
The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. A total of 10,866 patients with hypertension were enrolled for a comprehensive assessment of cardiovascular risk factors using data from the China Stroke Primary Prevention Trial. Plasma lipid levels and total leukocyte, neutrophil, and lymphocyte counts were determined according to standard methods. Peripheral differential leukocyte counts were consistently and positively associated with serum total cholesterol (TC), LDL cholesterol (LDL-C), and TG levels (all ...
Source: The Journal of Lipid Research - December 31, 2016 Category: Lipidology Authors: Liu, Y., Kong, X., Wang, W., Fan, F., Zhang, Y., Zhao, M., Wang, Y., Wang, Y., Wang, Y., Qin, X., Tang, G., Wang, B., Xu, X., Hou, F. F., Gao, W., Sun, N., Li, J., Venners, S. A., Jiang, S., Huo, Y. Tags: Patient-Oriented and Epidemiological Research Source Type: research

Blood lipid levels, statin therapy and the risk of intracerebral hemorrhage
Dyslipidemia has been proven to play an important role in the occurrence and development of the ischemic stroke and lipid-lowering therapy could significantly decrease the risk of the ischemic stroke. However,...
Source: Lipids in Health and Disease - March 1, 2016 Category: Lipidology Authors: Yingxu Ma, Zhaokai Li, Liang Chen and Xiangping Li Source Type: research

Determination of serum brassicasterol in spontaneously hypertensive rats stroke ‐prone fed a high‐ergosterol diet by ultra performance liquid chromatography
A method for the determination of ergosterol, brassicasterol, and cholesterol has been developed by ultra performance liquid chromatography with ultraviolet detection (UPLC‐UV). Using an ODS column and a mobile phase of acetonitrile‐water (95:5, v/v), we found that the peak area was linearly related to the amount of sterols injected, ranging from 1.5 to 100 μmol/L (r ≥ 0.998), except for cholesterol (2.5–400 μmol/L). Repeated injection showed that the relative standard deviation (RSD) at 50 μmol/L of sterols was less than 7.1% (intra‐day, n = 6) and 13% (inter‐day, n = 3). Ergosterol and br...
Source: European Journal of Lipid Science and Technology - October 12, 2015 Category: Lipidology Authors: Takaaki Ohtsubo, Ryo Kageyama, Yuji Koseki, Junya Hagi, Akira Kotani, Kazuhiro Yamamoto, Fumiyo Kusu, Tsuyoshi Miura, Hideki Hakamata Tags: Research Article Source Type: research

Optimized Extraction of 2‐Arachidonyl Glycerol and Anandamide from Aortic Tissue and Plasma for Quantification by LC‐MS/MS
In this study, we investigated several sample preparation options for the LC‐MS quantification of AEA and 2‐AG from plasma and aortic tissue. The extractions considered included liquid‐liquid (LLE), solid‐phase (SPE), and supported‐liquid (SLE). Some extraction protocols yielded high analyte recovery and prevention of 1‐AG/2‐AG isomerization. Our results indicate that a liquid‐liquid extraction using toluene yields the highest recovery for both analytes, coupled with low ionization suppression in the mass spectrometer. This extraction and corresponding LC‐MS/MS assay provides a simple, high throughput mec...
Source: European Journal of Lipid Science and Technology - June 23, 2015 Category: Lipidology Authors: Christopher Garst, Makenzie Fulmer, Doug Thewke, Stacy Brown Tags: Short Communication Source Type: research

Priority Paper Evaluation: Reverse epidemiology in ischemic stroke: high cholesterol as a predictor of improved survival in stroke patients
Clinical Lipidology April 2014, Vol. 9, No. 2, Pages 135-139.
Source: Future Medicine: Clinical Lipidology - June 11, 2014 Category: Lipidology Tags: article Source Type: research

Two lipids in the diet, rather than cholesterol, are responsible for heart failure and stroke
Clinical Lipidology , Ahead of Print, Pages 1-16.
Source: Future Medicine: Clinical Lipidology - January 29, 2014 Category: Lipidology Tags: article Source Type: research